Results 41 to 50 of about 8,412,816 (292)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Brownian motion near a partial-slip boundary: A local probe of the no-slip condition [PDF]

Physics of Fluids, 2005
Motivated by experimental evidence of violations of the no-slip boundary condition for liquid flow in micrometer-scale geometries, we propose a simple, complementary experimental technique that has certain advantages over previous studies. Instead of relying on externally induced flow or probe motion, we suggest that colloidal diffusivity near solid ...
Lauga, Eric, Squires, Todd M.
openaire   +3 more sources

Mozambique Channel Eddies in GCMs: A question of resolution and slippage [PDF]

, 2013
Hydrographic observations in the 21st century have shown that the flow within the MozambiqueChannel is best described by a series of large poleward-propagating anticyclonic eddies, rather than, aspreviously thought, a continuous intense western boundary ...
Coward, A.C., Quartly, GD, de Cuevas, B.A., Coward, AC, de Cuevas, BA, Quartly, G.D.   +5 more
core   +1 more source

Using fluorescence fluctuation spectroscopy to quantify molecular dynamics within cells

FEBS Open Bio, EarlyView.
Microscopy techniques like fluorescence correlation spectroscopy (FCS) and number and brightness analysis (N&B) allow to quantify concentrations, diffusion rates, and oligomerization of fluorescently labeled molecules in the living cell. In this protocol the principles of how to set up these types of experiments are described including calibration ...
Mark A. Hink
wiley   +1 more source

On the Navier-Slip Boundary Condition for Computations of Impinging Droplets [PDF]

2015 IEEE 22nd International Conference on High Performance Computing Workshops, 2015
A mesh-dependent relation for the slip number in the Navier-slip with friction boundary condition for computations of impinging droplets with sharp interface methods is proposed. The relation is obtained as a function of Reynolds number, Weber number and the mesh size.
Jagannath Venkatesan, Sashikumaar Ganesan   +1 more
openaire   +3 more sources

A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions

Advanced Engineering Materials, EarlyView.
This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice, Krzysztof S. Stopka, Michael D. Sangid   +2 more
wiley   +1 more source

Synergistic Exploration of Heat Transfer for Integration Magnetohydrodynamics of Nanofluids Peristaltic Transport within Annular Tubes

Mathematics
The problem of treating cancer is considered one of the most important daily challenges that affect the lives of people with cancer. This research deals with solving this problem theoretically.
Muhammad Magdy, Ramzy Abumandour, Islam Eldesoky, Hammad Alotaibi   +3 more
doaj   +1 more source

Microstructural Evolution and Vacancy Defect Formation in Mn–Mo–Ni RPV Steel Under Low Cycle Fatigue: Insights From EBSD and PALS

Advanced Engineering Materials, EarlyView.
Low‐cycle fatigue damage in Mn–Mo–Ni reactor pressure vessel steel is examined using a combined electron backscatter diffraction and positron annihilation lifetime spectroscopy approach. The study correlates texture evolution, dislocation substructure development, and vacancy‐type defect formation across uniform, necked, and fracture regions, providing
Apu Sarkar, Dhanadeep Dutta, G. Bharat Reddy   +2 more
wiley   +1 more source

Magnetohydrodynamic water-based hybrid nanofluid flow comprising diamond and copper nanoparticles on a stretching sheet with slips constraints

Open Physics
Hybrid nanofluid problems are used for augmentation of thermal transportation in various industrial applications. Therefore, the present problem is studied for the heat and mass transportation features of hybrid nanofluid caused by extending surface ...
Yasmin Humaira, AL-Essa Laila A., Lone Showkat Ahmad, Alrabaiah Hussam, Raizah Zehba, Saeed Anwar   +5 more
doaj   +1 more source