Results 41 to 50 of about 8,538 (283)
Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Advanced Engineering Materials, EarlyView.The tribological behavior of 100Cr6 steel spheres textured via Vickers microindentation is evaluated under lubricated sliding by varying both dimple size and density. Fine and dense textures significantly reduce friction across all lubrication regimes, while large dimples increase it.
Farideh Davoodi +3 more
wiley +1 more source
A Workflow to Accelerate Microstructure‐Sensitive Fatigue Life Predictions
Advanced Engineering Materials, EarlyView.This study introduces a workflow to accelerate predictions of microstructure‐sensitive fatigue life. Results from frameworks with varying levels of simplification are benchmarked against published reference results. The analysis reveals a trade‐off between accuracy and model complexity, offering researchers a practical guide for selecting the optimal ...
Luca Loiodice +2 more
wiley +1 more source
Deformation factors and failure modes of bedrock landslides in Yangxin County, Hubei Province
地质科技通报, 2022 The deformation of slopes is comprehensively controlled by many factors, and the sensitivity and action rules of different factors are obviously different in the deformation process.
Jian Wang +6 more
doaj +1 more source
Advanced Engineering Materials, EarlyView.A flexure‐based variable stiffness structure is developed by integrating phase‐change modulation and adhesive interfacial locking of gallium. The design enables a wide stiffness variability, transitioning from soft, flexible behavior to rigid, load‐supporting performance.
Sungjin Kim +2 more
wiley +1 more source
Applied Sciences, 2023 At present, there are very few vibration test designs for compressor stator blades in damped blade test research, and there is a lack of consideration of the holding ring structure of the blade installation.
Jiaobin Ma +3 more
doaj +1 more source
Induction motor slip control with efficiency optimization using fuzzy logic techniques [PDF]
, 1997 This paper describes a fuzzy logic based slip controller for an induction motor, with efficiency optimization for steady state operation. The speed control is accomplished through a Mandani type fuzzy controller, with 11 rules, taking speed error ...
Afonso, João L. +3 more
core
Low‐Angle Grain Boundaries and Re‐Segregation in Single‐Crystalline Ni‐Base Superalloys
Advanced Engineering Materials, EarlyView.This work demonstrates that Re‐segregation at low‐angle grain boundaries (LAGBs) in Ni‐base superalloys is influenced by misorientation angle. Advanced microscopy and atom probe tomography reveal that higher misorientation angles increases Re‐segregation.
Alireza B. Parsa +9 more
wiley +1 more source
IEEE AccessThe translation of classical Sanskrit texts presents unique challenges due to the language’s complex morpho-phonological structure, rich grammatical system, and cultural-philosophical depth.
N. Biraja Isac, Himansu Das
doaj +1 more source