Results 31 to 40 of about 6,195 (254)
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source
Blue Velvet Slippers with Fur and Bow Trim
, 2010 Blue velvet slippers with wedge heels; mule style with fur and bow trim - from the The Betty Smithers Design Collection at Staffordshire University.
The Betty Smithers Design Collection at Staffordshire University +1 more
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Molecular Oncology, EarlyView.In head and neck squamous cell carcinoma (HNSCC) p53 and p63 exert opposite roles on the transcription regulation of the lncRNA NEAT1. Under basal conditions, p53 levels are low and p63 represses NEAT1 expression. Upon genotoxic stress, p53 is rapidly induced, displacing p63 from the NEAT1 promoter leading to NEAT1 transcriptional activation and ...
Sara De Domenico +5 more
wiley +1 more source
, 2023 Sky blue slippers with wooded bottoms and beautiful flowers knitted upon the tops.https://commons.und.edu/fritzcollection/1128/thumbnail ...
Unknown, Artist
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Section VIII, 2e - Murderer's Slippers (Jinna-arbill) (Central Australia)
, 2012 Murderer's Slippers (Jinna-arbill) (Central Australia) The slippers worn by cannibal raiders when they preyed on other groups and captured, by preference, young girls and boys for eating, were made of hair, fur and feathers.
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Molecular Oncology, EarlyView.This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault +12 more
wiley +1 more source
'A Tale of Two Slippers' : Uncanny parody, power and the performance of writing
, 2018 In this combined critical and creative work, my experimental short story ‘A Tale of Two Slippers’ (in which a character escapes a text to kill her author) is framed through an introduction in which cultural studies theory and reflections on practice-led ...
Hunn, Deborah
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Molecular Oncology, EarlyView.Incomplete microwave ablation (iMWA) of liver cancer triggers a biphasic progression in residual tumors. At Day 3, the microenvironment is characterized by acute inflammatory responses and extracellular matrix (ECM) remodeling. By Day 14, a profound shift occurs toward oncogenic signal transduction and immunosuppression, marked by macrophage ...
Yu Liu +9 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source