Results 41 to 50 of about 152,103 (312)

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Slit-based irrigation catheters can reduce procedure-related ischemic stroke in atrial fibrillation patients undergoing radiofrequency catheter ablation

PLoS ONE, 2020
Open irrigation ablation catheters are now the standard in radiofrequency catheter ablation (RFCA) of atrial fibrillation (AF). Among various irrigation catheters, laser-cut slit-based irrigation system (Cool Flex and FlexAbility) has a unique design to ...
Yun Gi Kim, Jaemin Shim, Ki Yung Boo, Do Young Kim, Kwang-No Lee, Jong-Il Choi, Young-Hoon Kim, Giuseppe Coppola   +7 more
doaj   +2 more sources

Podosit dan Slit Diafragma serta Perannya

Sari Pediatri, 2016
Podosit dan slit diafragma adalah bagian dari dinding kapiler glomerulus ginjal yang mempunyai peran yang sangat penting dalam filtrasi glomerulus. Berbagai molekul terdapat pada podosit dan slit diafragma yang berperan penting dalam integritas proses ...
Sudung O. Pardede
doaj   +1 more source

Deriving the slit functions from OMI solar observations and its implications for ozone-profile retrieval [PDF]

Atmospheric Measurement Techniques, 2017
The Ozone Monitoring Instrument (OMI) has been successfully measuring the Earth's atmospheric composition since 2004, but the on-orbit behavior of its slit functions has not been thoroughly characterized.
K. Sun, X. Liu, G. Huang, G. González Abad, Z. Cai, K. Chance, K. Yang   +6 more
doaj   +1 more source

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Two-Beam Emitting Via a Single Subwavelength Metal Slit Surrounded by Mixed-Period Dielectric Grooves

IEEE Photonics Journal, 2013
We use mixed-period dielectric grooves to surround a single metal slit to realize two-beam nonsymmetrical and symmetrical emitting for the transmitted light emerged from the subwavelength slit.
Ying-jie Su, Hung-chun Chang
doaj   +1 more source

Glycosylated LGALS3BP is highly secreted by bladder cancer cells and represents a novel urinary disease biomarker

Molecular Oncology, EarlyView.
Urinary LGALS3BP is elevated in bladder cancer patients compared to healthy controls as detected by the 1959 antibody–based ELISA. The antibody shows enhanced reactivity to the high‐mannose glycosylated variant secreted by cancer cells treated with kifunensine (KIF).
Asia Pece, Giulio Lovato, Ilaria Cela, Arianna Mercatelli, Benedetta Ferro, Jussi Nikkola, Sara Pagotto, Tommaso Grottola, Vincenzo De Laurenzi, Rossella Cicchetti, Antonio Marchetti, Luigi Schips, Rossano Lattanzio, Stefano Iacobelli, Emily Capone, Peter Black, Mads Daugaard, Michele Marchioni, Gianluca Sala   +18 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

A Nonlinear Damper with Dynamic Load and an Elastic Slit Membrane: Modeling and Interaction Analysis

Applied Sciences
This article presents research into the feasibility of applying a nonlinear damper of a new conceptual structure. The key component of the damper is a circular membrane with slits that can move in a cylinder filled with viscous fluid.
Mostafa Sadeghian, Kestutis Pilkauskas, Paulius Palevicius, Jurate Ragulskiene, Giedrius Janusas, Viktoras Dorosevas, Arvydas Palevicius   +6 more
doaj   +1 more source

Sub-Wavelength Slit-Assisted Binary Metallic Lens Design for Effective Multifocusing via Phase Superposition Method

IEEE Access, 2020
This paper proposes a multifocal lens design method named phase superposition method (PSM) and a methodology to increase the efficiency of metallic binary zone plates through a sub-wavelength slit array.
Kyoungyoon Park, Hyuntai Kim
doaj   +1 more source