Results 231 to 240 of about 25,655 (271)

Targeting Lactate‐Driven Stromal Autophagy via MCT1 Disrupts the Immunosuppressive Niche and Sensitizes Pancreatic Cancer to PD‐1 Blockade

Advanced Science, EarlyView.
Tumor‐derived lactate activates PSCs through MCT1‐mediated Vps34 lactylation and autophagy. These activated PSCs secrete CXCL9/10, upregulating PD‐1 on CD8+ T cells via the CXCR3/STAT3 axis to foster immunosuppression. Disrupting this metabolic crosstalk by targeting MCT1 effectively sensitizes pancreatic cancer to PD‐1 blockade, presenting a promising
Wenfeng Zhuo, Rong Hu, Yuhang Hu, Ping Hu, Shengbo Han, Guozheng Lv, Zhu Zeng, Yong Zhao, Yang Li, Yan Huang, Yingsong Zhao, Hongda Wang, Guangyu Zhao, Eryang Zhao, Gang Zhao   +14 more
wiley   +1 more source

Meningeal CSF transport varies across parasagittal dura subregions with age in humans. [PDF]

J Cereb Blood Flow Metab
Malis V, Jung HN, Kuwatsuru Y, Bae WC, Miyazaki M.   +4 more
europepmc   +1 more source

PRMT9 Aggravated Dopaminergic Neurodegeneration in Parkinson's Disease Model by Facilitating the Degradation of DUSP26 and Inducing Mitochondrial Dysfunction

Advanced Science, EarlyView.
In the pathological state of PD induced by MPP+, the upregulated PRMT9 in dopaminergic neurons translocates into mitochondrion and interacts with DUSP26 and catalyzes its arginine methylation, leading to the ubiquitin‐proteasomal degradation of DUSP26 mediated by Trim32.
Tengfei Liu, Xiaomeng Song, Xin Guo, Rui Xiao, Ru Sun, Qiuran Ji, Lu Yu, Yiquan Li, Qingyi Fu, Qidi Xue, Lingjun Kong, Lin Chen, Chengjiang Gao, Huiqing Liu   +13 more
wiley   +1 more source

Bi-component modeling of cerebrospinal fluid outflow using Time-SLIP MRI. [PDF]

Fluids Barriers CNS
Malis V, Miyazaki M, Miyazaki M.
europepmc   +1 more source

Spontaneous complexity in the dynamics of slow laboratory earthquakes. [PDF]

Nat Commun
Pozzi G, Volpe G, Taddeucci J, Cocco M, Marone C, Collettini C.   +5 more
europepmc   +1 more source

Back to the Future? Institutional Learning Curves and Intraoperative Fracture Rates Associated With Adoption of a Cemented Composite Beam Stem for Hemiarthroplasty. [PDF]

Geriatr Orthop Surg Rehabil
Hennessy O, Field K, Flynn SO, Dahly D, Rowan FE, Pomeroy E, Murphy T, Cleary MS.   +7 more
europepmc   +1 more source

Off-fault damage controls near-surface rupture behaviour in soft sediments. [PDF]

Nat Commun
De Paola N, Bullock RJ, Holdsworth RE, Marco S, Nielsen S.   +4 more
europepmc   +1 more source

Slow Slip Events in New Zealand

Annual Review of Earth and Planetary Sciences, 2020
Continuously operating global positioning system sites in the North Island of New Zealand have revealed a diverse range of slow motion earthquakes on the Hikurangi subduction zone. These slow slip events (SSEs) exhibit diverse characteristics, from shallow (<15 km), short (<1 month), frequent (every 1–2 years) events in the northern part of the ...
Laura M. Wallace, Wallace, Laura M.
core   +4 more sources

Slow slip in subduction zones

, 2022
Cataclasites are a characteristic rock type found in drill cores from active faults as well as in exposed fossil subduction faults. Here, cataclasites are commonly associated with evidence for pervasive pressure solution and abundant hydrofracturing.
Oncken, Onno (Prof. Dr.), Angiboust, Samuel, Dresen, Georg (Prof. Dr.)   +2 more
openaire   +3 more sources

Slip weakening as a mechanism for slow earthquakes

Nature Geoscience, 2013
Slow earthquakes form part of a spectrum of fault behaviour between steady creep and fast rupture during a normal earthquake. Laboratory simulations of slow slip in rock samples taken from the Nankai subduction zone, Japan, reveal similar characteristics to fast earthquakes, implying that some slow slip events could be prematurely arrested earthquakes.
Ikari M. J., Marone C. J., Saffer D. M., Kopf A. J.   +3 more
openaire   +3 more sources