Results 41 to 50 of about 830,987 (240)

The geophysics, geology and mechanics of slow fault slip [PDF]

, 2018
Modern geodetic and seismologic observations describe the behavior of fault slip over a vast range of spatial and temporal scales. Slip at sub-seismogenic speeds is evident from top to bottom of lithospheric faults and plays an important role throughout ...
Bürgmann, Roland, Roland Bürgmann, Bürgmann, Roland,   +2 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Complex characteristics of slow slip events in subduction zones reproduced in multi‐cycle simulations

Geophysical Research Letters, 2012
Since the discovery of slow slip events along subduction zone interfaces worldwide, dense geodetic and seismic networks have illuminated detailed characteristics of these events and associated tremor.
Harmony V. Colella, James H. Dieterich, Keith Richards‐Dinger, Allan M. Rubin   +3 more
doaj   +1 more source

MITF maintains genome stability in nonmelanocyte lineages

Molecular Oncology, EarlyView.
MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir, Adrián López García de Lomana, Thejus B. Venkatesh, Kritika Kirty, Snaevar Sigurdsson, Linda Vidarsdottir, Ramile Dilshat, Erla Sveinbjornsdottir, Snaedis Ragnarsdottir, Daniel H Magnusson, Maria R. Bustos, Eirikur Steingrimsson, Thorkell Gudjonsson, Stefan Sigurdsson   +13 more
wiley   +1 more source

Translating whole‐genome doubling into precision medicine in cancer

Molecular Oncology, EarlyView.
Whole‐genome doubling creates a WGD‐positive tumor state characterized by persistent chromosomal instability, karyotypic diversification, and cellular stress. These same biological pressures drive aggressive tumor evolution while exposing therapeutic vulnerabilities, providing a rationale for WGD‐informed precision medicine. Whole‐genome doubling (WGD)
Sejung Lee, Junghyeok Lim, Jinhyuk Bhin
wiley   +1 more source

Fluid upwelling across the Hikurangi subduction thrust during deep slow-slip earthquakes

Communications Earth & Environment
Slow-slip events at global subduction zones relieve tectonic stress over days to years. Through slow-slip cycles, high fluid pressures observed at the top of subducting plates are thought to fluctuate, potentially due to the valving action of an ...
Pasan Herath, Pascal Audet
doaj   +1 more source

Defining the Relationship between Seismicity and Deformation at Regional and Local Scales [PDF]

, 2013
In this thesis, I use source inversion methods to improve understanding of crustal deformation along the Nyainquentanglha (NQTL) Detachment in Southern Tibet and the Piceance Basin in northwestern Colorado.
Williams, Nneka Njeri Akosua
core   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Seismic Swarms Unveil the Mechanisms Driving Shallow Slow Slip Dynamics in the Copiapó Ridge, Northern Chile

Geophysical Research Letters
Like earthquakes, slow slip events release elastic energy stored on faults. Yet, the mechanisms behind slow slip instability and its relationship with seismicity are debated. Here, we use a seismo‐geodetic deployment to document a shallow slow slip event
Jannes Münchmeyer, Diego Molina‐Ormazabal, Mathilde Radiguet, David Marsan, Juan‐Carlos Baez, Francisco Ortega‐Culaciati, Andres Tassara, Marcos Moreno, Anne Socquet   +8 more
doaj   +1 more source

Towards Defect Phase Diagrams: From Research Data Management to Automated Workflows

Advanced Engineering Materials, EarlyView.
A research data management infrastructure is presented for the systematic integration of heterogeneous experimental and simulation data required for defect phase diagrams. The approach combines openBIS with a companion application for large‐object storage, automated metadata extraction, provenance tracking and federated data access, thereby supporting ...
Khalil Rejiba, Sang‐Hyeok Lee, Christina Gasper, Martina Freund, Sandra Korte‐Kerzel, Ulrich Kerzel   +5 more
wiley   +1 more source