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A noninvasive test for human prion disease using hair roots and scalp [PDF]

Scientific Reports
Invasive tests like cerebrospinal fluid (CSF) examination are highly effective for diagnosing human prion disease (HPD). Real-time quaking-induced conversion (RT-QuIC) CSF assay demonstrates 80–90% sensitivity for HPD diagnosis.
Thi-Thu-Trang Dong, Hiroyuki Honda, Akio Akagi, Yasushi Iwasaki, Hitaru Kishida, Tadashi Tsukamoto, Kensaku Kasuga, Hirotsugu Takashima, Tatsuhiro Terada, Kensuke Ikenaka, Takeshi Ikeuchi, Tsuyoshi Mori, Hideki Mochizuki, Kenjiro Ono, Yoshihisa Takiyama, Tsuyoshi Hamaguchi, Hiroyuki Murota, Nobuo Sanjo, Takeshi Fujimoto, Michio Kitayama, Koji Fujita, Motohiro Yukitake, Shinsuke Fujioka, Noriyuki Nishida, Yoshio Tsuboi, Tetsuyuki Kitamoto, Masaki Takao, Masahito Yamada, Hidehiro Mizusawa, Katsuya Satoh   +29 more
doaj   +2 more sources

In vitro slow-growth conservation, acclimatization, and genetic stability of virus-free apple plants

Horticulture Advances
In vitro slow-growth storage has long played an important role in maintaining valuable horticultural materials. It is particularly applicable to the conservation of virus-free materials recovered from meristem culture or shoot-tip cryotherapy.
Xian Lu, Pengpeng Sun, Ruihan Liu, Caiwen Wang, Lu Tong, Muhammad Mobeen Tahir, Xiaoyan Ma, Junhua Bao, Dong Zhang, Minrui Wang, Na An   +10 more
doaj   +2 more sources

Composition of human-specific slow codons and slow di-codons in SARS-CoV and 2019-nCoV are lower than other coronaviruses suggesting a faster protein synthesis rate of SARS-CoV and 2019-nCoV

Journal of Microbiology, Immunology and Infection, 2020
Translation of a genetic codon without a cognate tRNA gene is affected by both the cognate tRNA availability and the interaction with non-cognate isoacceptor tRNAs.
Chu-Wen Yang, Mei-Fang Chen
doaj   +1 more source

Parent–Child Separation Always Comes with a Cost

European Journal of Investigation in Health, Psychology and Education, 2023
In some situations, due to the risk of contagion, the recent COVID-19 pandemic forced parent–child separation to occur in attempts to slow down the spread of the virus [...]
Luca Cerniglia
doaj   +1 more source

Current estimates for HIV-1 production imply rapid viral clearance in lymphoid tissues. [PDF]

PLoS Computational Biology, 2010
It has recently been estimated that a single HIV-1 infected cell produces between and more than viral particles over its life span. Since body-wide estimates of the ratio of free virus to productively infected cells are smaller than and much smaller than
Rob J De Boer, Ruy M Ribeiro, Alan S Perelson   +2 more
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Simulation Agent-Based Model to Demonstrate the Transmission of COVID-19 and Effectiveness of Different Public Health Strategies

Frontiers in Computer Science, 2021
COVID-19 has changed the world fundamentally since its outbreak in January 2020. Public health experts and administrations around the world suggested and implemented various intervention strategies to slow down the transmission of the virus.
Yixing Wang, Hainan Xiong, Sijie Liu, Ara Jung, Ara Jung, Trish Stone, Leanne Chukoskie, Leanne Chukoskie   +7 more
doaj   +1 more source

Continuous HIV-1 Escape from Autologous Neutralization and Development of Cross-Reactive Antibody Responses Characterizes Slow Disease Progression of Children

Vaccines, 2021
The antibodies with different effector functions evoked by Human Immunodeficiency Virus type 1 (HIV-1) transmitted from mother to child, and their role in the pathogenesis of infected children remain unresolved. So, too, the kinetics and breadth of these
Stefania Dispinseri, Mariangela Cavarelli, Monica Tolazzi, Anna Maria Plebani, Marianne Jansson, Gabriella Scarlatti   +5 more
doaj   +1 more source

Detection of Lotmaria passim, Crithidia mellificae and Replicative Forms of Deformed Wing Virus and Kashmir Bee Virus in the Small Hive Beetle (Aethina tumida)

Pathogens, 2021
Knowledge regarding the honey bee pathogens borne by invasive bee pests remains scarce. This investigation aimed to assess the presence in Aethina tumida (small hive beetle, SHB) adults of honey bee pathogens belonging to the following groups: (i ...
Antonio Nanetti, James D. Ellis, Ilaria Cardaio, Giovanni Cilia   +3 more
doaj   +1 more source

A Market Scheduling for New Normal Logistics in the Wake of Corona Virus Diseases-19 in Bandung City

Jurnal Rekayasa Sistem Industri, 2020
Recent developments on the worldwide spread of Corona Virus Diseases-19 (COVID-19) show the vulnerability of human beings to pandemic risks in terms of biological, social, and economic factors.
Carles Sitompul, Paulina Kus Ariningsih, Fran Setiawan   +2 more
doaj   +1 more source

Hindlimb muscle representations in mouse motor cortex defined by viral tracing

Frontiers in Neuroanatomy, 2023
IntroductionDescending pathways from the cortex to the spinal cord are involved in the control of natural movement. Although mice are widely used to study the neurobiology of movement and as models of neurodegenerative disease, an understanding of motor ...
Lauren Maurer, Maia Brown, Tamandeep Saggi, Alexia Cardiges, Christi L. Kolarcik, Christi L. Kolarcik, Christi L. Kolarcik, Christi L. Kolarcik, Christi L. Kolarcik   +8 more
doaj   +1 more source