Results 131 to 140 of about 189,686 (299)

Timing is everything: Expert opinion on researching epilepsy rhythms by the ILAE Task Force on Chronobiology

Epilepsia, EarlyView.
Abstract Recurrent seizures, the hallmark of epilepsy, are influenced by rhythms operating over multiple timescales. Chronobiology is the study of biological timing that aims to explain temporal patterns of events like seizures. Fueled by recent advances in genetics, computational modeling, and device engineering, the chronobiology of epilepsy is now a
Maxime O. Baud, Christophe Bernard, Birgit Frauscher, Philippa J. Karoly, Vikram R. Rao   +4 more
wiley   +1 more source

Memantine treatment in individuals with GRIN gain‐of‐function variants is associated with improvements in behavior, development, and seizure frequency

Epilepsia, EarlyView.
Abstract Objective GRIN‐related disorders due to pathogenic variants in GRIN1, GRIN2A, GRIN2B, or GRIN2D genes are associated with altered N‐methyl‐D‐aspartate receptor (NMDAR) function. Functional changes include gain (GoF) and loss of receptor function (LoF). Clinical reports describing the use of the NMDAR blocker memantine in GRIN‐related disorders
Maike Karnstedt, Riley E. Perszyk, Scott J. Myers, Ellington McDaniels, Marta Somorai, Ingo Borggraefe, Danielle C. M. Veenma, An‐Sofie Schoonjans, Pasquale Striano, Tadeu A. Fantaneanu, Steffen Syrbe, Kristen Park, Wenjuan Chen, Hongjie Yuan, Stephen F. Traynelis, Timothy A. Benke, Johannes R. Lemke, Ilona Krey   +17 more
wiley   +1 more source

Development and validation of a deep survival model to predict time to seizure from routine electroencephalography

Epilepsia, EarlyView.
Abstract Objective This study was undertaken to develop and validate a deep survival model (EEGSurvNet) that analyzes routine electroencephalography (EEG) to predict individual seizure risk over time, comparing its performance to traditional clinical predictors such as interictal epileptiform discharges (IEDs).
Émile Lemoine, An Qi Xu, Mezen Jemel, Frédéric Lesage, Dang K. Nguyen, Elie Bou Assi   +5 more
wiley   +1 more source

Spectral entropy variability of intraoperative electrocorticography predicts outcome after epilepsy surgery in people with focal cortical dysplasia

Epilepsia, EarlyView.
Abstract Objective Epilepsy surgery in people with focal cortical dysplasia (FCD) requires accurate removal of all epileptogenic tissue, and outcome is difficult to predict. We explored whether spectral entropy, a fast computable electroencephalographic (EEG) feature, could estimate epileptic activity in intraoperative electrocorticography (ioECoG) and
Eline V. Schaft, Sem Hoogteijling, Dongqing Sun, Cyrille H. Ferrier, Pieter van Eijsden, Wim M. Otte, Galia Anguelova, Nick F. Ramsey, Maryse A. van't Klooster, Maeike Zijlmans, on behalf of the RESPect database study group, Charlotte van Asch, Lydia van de Berg, Dorien van Blooijs, Kim Boshuisen, Mireille Bourez, Kees Braun, Jan Willem Dankbaar, Matteo Demuru, Pieter van Eijsden, Cyrille Ferrier, Tineke Gebbink, Fernando Gomez‐Acebo Ruiz, Peter Gosselaar, Kimberley Grasmeijer, Renate van Griethuysen, Jiaojiao Guo, Irene Heijink, Monique Hobbelink, Friso Hoefnagels, Sem Hoogteijling, Geertjan Huiskamp, Sarah Jacobs, Floor Jansen, Susanne Jelsma, Nicole van Klink, Merel Koopmans, Frans Leijten, Wouter Maathuis, Mariska Mantione, Angelika Muhlebner, Brechje Olgers, Janine van Ophorst, Miranda Postma, Sandra van der Salm, Eline Schaft, Anniek van Schaik, Monique van Schooneveld, Dongqing Sun, Ziyi Wang, Martine van Zandvoort, Eva Zuidhoek, Willemiek Zweiphenning, Jack Zwemmer   +53 more
wiley   +1 more source

Spindle oscillations are generated in the dorsal thalamus and modulated by the thalamic reticular nucleus [PDF]

, 2008
Spindle waves occur during the early stage of slow wave sleep and are thought to arise in the thalamic reticular nucleus (TRN), causing inhibitory postsynaptic potential spindle-like oscillations in the dorsal thalamus that are propagated to the cortex ...
Chun-Hua Liu, Jufang He, Li-Xia Gao, Xian-Kai Meng, Yan-Qin Yu, Yi Ping Guo, Ying Xiong, Ying-Shing Chan   +7 more
core   +1 more source

Inroads into epilepsy through high‐frequency oscillations: Achievements and benchmark areas for improvement

Epilepsia, EarlyView.
Abstract High‐frequency oscillations (HFOs) were discovered more than 20 years ago, and since then they have been studied intensively in the context of epilepsy. HFOs encompass a broad spectrum of oscillations, typically ranging from 80 Hz to several kHz, that include both normal and pathological oscillations, documented in people with epilepsy and ...
Christos Panagiotis Lisgaras, Birgit Frauscher, Jean Gotman, Julia Jacobs, Philippe Kahane, Richard J. Staba, Maeike Zijlmans   +6 more
wiley   +1 more source

Pitfall of false localization in basal temporal epilepsy: A clinical vignette

Epileptic Disorders, EarlyView.
Mathieu Dhoisne, Romain Carron, Fabrice Bartolomei, Stanislas Lagarde   +3 more
wiley   +1 more source

Deep characterization of refractory epilepsy due to mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE) and insights into the role of invasive monitoring

Epilepsia, EarlyView.
Abstract Objective Epilepsy surgery is an effective treatment option for patients with medically refractory epilepsy due to mild malformation of cortical development with oligodendroglial hyperplasia (MOGHE). The success of surgery depends on the accurate localization of the epileptogenic zone, which can be challenging due to the subtle imaging ...
Jean Khoury, Ingmar Blümcke, Robyn M. Busch, Balu Krishnan, Juan Bulacio, William Bingaman, Demitre Serletis, Imad Najm   +7 more
wiley   +1 more source

Slow Wave Sleep and Long Duration Spaceflight [PDF]

To review the literature on slow wave sleep (SWS) in long duration space flight, and place this within the context of the broader literature on SWS particularly with respect to analogous environments such as the Antarctic.
Arias, D., Leveton, L., Orr, M., Whitmire, A.   +3 more
core   +1 more source

Characterizing early behavioral and social–emotional problems in young children with SCN1A+ Dravet syndrome: Findings from the ENVISION prospective natural history study

Epilepsia, EarlyView.
Abstract Objective Dravet syndrome (DS) is the prototypic developmental and epileptic encephalopathy, characterized by drug‐resistant seizures, developmental slowing, and many other morbidities. Detailed characterization of behavioral phenotypes and social–emotional skill development are limited.
Ingrid E. Scheffer, M. Scott Perry, Joseph Sullivan, Susana Boronat, James Wheless, Andreas Brunklaus, Linda Laux, Anup D. Patel, Colin Roberts, Dennis Dlugos, Deborah Holder, Kelly Knupp, Matt Lallas, Steven Phillips, Eric Segal, Dennis Lal, Elaine Wirrell, Sameer M. Zuberi, Rebecca Shaffer, Mary Wojnaroski, Madison M. Berl, Sarah Christensen, Emma S. James, Maria Candida Vila, Norman Huang, Jacqueline S. Gofshteyn, Salvador Rico   +26 more
wiley   +1 more source