Results 81 to 90 of about 2,316,235 (248)

Transient Sleep Deprivation Induces Persistent Auditory Neuropathy via ROS‐Initiated Neuroinflammation and BK Channel Suppression

open access: yesAdvanced Science, EarlyView.
Sleep disturbance severity closely tracks hearing loss in a clinical cohort, yet the mechanistic link remains unclear. Acute sleep deprivation is shown to trigger transient cochlear oxidative stress that switches into a self‐sustaining neuroinflammatory state, suppressing BK channels and causing irreversible synaptopathy.
Dan Chen   +11 more
wiley   +1 more source

Abstract Representation of Movement Parameters in Basal Ganglia Output

open access: yesAdvanced Science, EarlyView.
The basal ganglia output provides a scalable velocity/position signal across behavioral contexts, supporting the idea that these variables are represented in the brain as abstract entities rather than as fixed changes in joint angles or specific sets of body effectors.
Ana Silvia Báez‐Cordero   +3 more
wiley   +1 more source

Local increase of sleep slow wave activity after three weeks of working memory training in children and adolescents

open access: yes, 2015
STUDY OBJECTIVES Evidence is accumulating that electroencephalographic (EEG) sleep slow wave activity (SWA), the key characteristic of deep sleep, is regulated not only globally, but also locally.
Huber, Reto; https://orcid.org/   +5 more
core   +1 more source

Continuous Molecular Monitoring Using Electrochemical Aptamer‐Based Sensors: Remaining Challenges for Long‐Term In Vivo Deployment

open access: yesAdvanced Science, EarlyView.
Continuous molecular monitoring using electrochemical aptamer‐based sensors enables real‐time tracking of dynamic biomarkers with transformative potential for precision medicine. Achieving clinically relevant month‐long stability remains a central challenge due to multiple degradation pathways.
Shibo Liu, Xiangling Li, Wei Ouyang
wiley   +1 more source

Age-Related Decline in Controlled Retrieval: The Role of the PFC and Sleep

open access: yesNeural Plasticity, 2012
Age-related cognitive impairments often include difficulty retrieving memories, particularly those that rely on executive control. In this paper we discuss the influence of the prefrontal cortex on memory retrieval, and the specific memory processes ...
Kristine A. Wilckens   +2 more
doaj   +1 more source

Characteristics of sleep slow waves in children and adolescents

open access: yes, 2010
STUDY OBJECTIVES: Slow waves, a major electrophysiological characteristic of non-rapid eye movement sleep, undergo prominent changes across puberty.
Tononi, G   +11 more
core   +1 more source

Modulation of Presynaptic Inhibitory Retinal Circuits for Retinal Ganglion Cell Neuroprotection in Glaucoma

open access: yesAdvanced Science, EarlyView.
Ocular hypertension induces early hyperactivity in inner retinal inhibitory circuitry before substantial retinal ganglion cell loss. Sustained pharmacological inhibition of GABAergic/glycinergic neurotransmission and Vgat‐targeted Lin28 expression suppress this hyperactivity and improve RGC survival without reducing intraocular pressure. These findings
Eunji Hong   +7 more
wiley   +1 more source

Processing of auditory word pairs during slow-wave sleep: a closed-loop approach [PDF]

open access: yes, 2019
Every day we experience episodes, which we encode effortlessly on the fly by forming what, where and when associations. A recently published experiment of our research group on vocabulary learning during deep sleep suggests that hippocampus-mediated ...
Schmidig, Flavio   +2 more
core  

Effect of Conditioned Stimulus Exposure during Slow Wave Sleep on Fear Memory Extinction in Humans

open access: yes, 2015
Study Objectives: Repeated exposure to a neutral conditioned stimulus (CS) in the absence of a noxious unconditioned stimulus (US) elicits fear memory extinction.
Zhang, Wei-Hua   +9 more
core   +1 more source

A Language‐Guided Multimodal Foundation Model for Zero‐Shot and Multi‐Task Brain Signal Analysis

open access: yesAdvanced Intelligent Systems, EarlyView.
METIS aligns brain signals with natural‐language instructions to enable zero‐shot and multi‐task brain signal analysis. Pretrained on over 70 000 h of EEG and iEEG recordings, it generalizes across sleep stage classification, epilepsy detection, and neurological disorder diagnosis, providing a scalable foundation model for clinically meaningful brain ...
Mingzhi Chen   +3 more
wiley   +1 more source

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