Results 41 to 50 of about 343,317 (203)

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

First Stars. I. Evolution without mass loss

, 2010
The first generation of stars was formed from primordial gas. Numerical simulations suggest that the first stars were predominantly very massive, with typical masses M > 100 Mo.
A. Ferrara, A. Heger, A. Heger, A. Kogut, A. Sokasian, B.J. Carr, B.J. Carr, C. Angulo, C. Chiosi, C.A. Iglesias, C.L. Fryer, D. Bahena, D. Bahena, D. Ezer, D. Schaerer, E.T. Visniac, F. Nakamura, F.J. Rogers, G. Meynet, H. Umeda, H. Umeda, H.E. Bond, I. Baraffe, J. Klapp, J. Klapp, J. Klapp, J. Miralda-Escudé, J. Tumlinson, J. Tumlinson, J. Tumlinson, J.P. Ostriker, J.R. Bond, J.S.B. Wyithe, K. Omukai, L. Portinari, M. Tegmark, N. Yoshida, N.Y. Gnedin, P. Marigo, R. Cayrel, R. Cayrel, R. Cen, R. Larson, R.P. Kudritzki, R.P. Kudritzki, S. Dodelson, T. Abel, T. Abel, V. Bromm, V. Bromm, V. Bromm, V. Bromm, V. Bromm, V. Castellani, V. Castellani, W.W. Ober, Z. Barkat, Z. Haiman   +57 more
core   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

Isometric Immersions via Compensated Compactness for Slowly Decaying Negative Gauss Curvature and Rough Data

, 2015
In this paper the method of compensated compactness is applied to the problem of isometric immersion of a two dimensional Riemannian manifold with negative Gauss curvature into three dimensional Euclidean space.
Christoforou, Cleopatra, Slemrod, Marshall   +1 more
core   +1 more source

Identification of serum protein biomarkers for pre‐cancerous lesions associated with pancreatic ductal adenocarcinoma

Molecular Oncology, EarlyView.
This work identified serum proteins associated with pancreatic epithelial neoplasms (PanINs) and early‐stage PDAC. Proteomics screens assessed genetically engineered mice with abundant PanINs, KPC mice (Lox‐STOP‐Lox‐KrasG12D/+ Lox‐STOP‐Lox‐Trp53R172H/+ Pdx1‐Cre) before PDAC development and also early‐stage PDAC patients (n = 31), compared to benign ...
Hannah Mearns, Jaclyn S. Long, Sergio Lilla, Kelly Hodge, Marcus J. G. W. Ladds, Colin Nixon, Paula Fernández‐Palanca, Sara Zanivan, Pilar Acedo, Stephen P. Pereira, Kevin M. Ryan   +10 more
wiley   +1 more source

Distributed Stochastic Optimization over Time-Varying Noisy Network

, 2020
This paper is concerned with distributed stochastic multi-agent optimization problem over a class of time-varying network with slowly decreasing communication noise effects. This paper considers the problem in composite optimization setting which is more
Ho, Daniel W. C., Yu, Zhan, Yuan, Deming
core  

RIPK4 function interferes with melanoma cell adhesion and metastasis

Molecular Oncology, EarlyView.
RIPK4 promotes melanoma growth and spread. RIPK4 levels increase as skin lesions progress to melanoma. CRISPR/Cas9‐mediated deletion of RIPK4 causes melanoma cells to form less compact spheroids, reduces their migratory and invasive abilities and limits tumour growth and dissemination in mouse models.
Norbert Wronski, Sławomir Lasota, Ewelina Madej, Anna A. Brożyna, Małgorzata Szczygieł, Agnieszka Harazin‐Lechowska, Jan Czerbniak, Janusz Rys, Jaroslaw Czyz, Agnieszka Wolnicka‐Glubisz   +9 more
wiley   +1 more source

The limit distribution of ratios of jumps and sums of jumps of subordinators [PDF]

, 2014
Let $V_{t}$ be a driftless subordinator, and let denote $m_{t}^{(1)} \geq m_{t}^{(2)} \geq\ldots$ its jump sequence on interval $[0,t]$. Put $V_{t}^{(k)} = V_{t} - m_{t}^{(1)} - \ldots- m_{t}^{(k)}$ for the $k$-trimmed subordinator.
Kevei, Péter, Mason, David M.
core   +1 more source