Next‐generation proteomics improves lung cancer risk prediction
Molecular Oncology, EarlyView.This is one of very few studies that used prediagnostic blood samples from participants of two large population‐based cohorts. We identified, evaluated, and validated an innovative protein marker model that outperformed an established risk prediction model and criteria employed by low‐dose computed tomography in lung cancer screening trials.
Megha Bhardwaj +4 more
wiley +1 more source
Cell surface interactome analysis identifies TSPAN4 as a negative regulator of PD‐L1 in melanoma
Molecular Oncology, EarlyView.Using cell surface proximity biotinylation, we identified tetraspanin TSPAN4 within the PD‐L1 interactome of melanoma cells. TSPAN4 negatively regulates PD‐L1 expression and lateral mobility by limiting its interaction with CMTM6 and promoting PD‐L1 degradation.
Guus A. Franken +7 more
wiley +1 more source
Weakly nonlinear thermoacoustics for stacks with slowly varying pore cross-sections [PDF]
A general theory of thermoacoustics is derived for arbitrary stack pores. Previous theoretical treatments of porous media are extended by considering arbitrarily shaped pores with the only restriction that the pore cross-sections vary slowly in the ...
Molenaar, J. +3 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
A class of robust numerical methods for solving dynamical systems with multiple time scales [PDF]
, 2019 In this paper, we develop a class of robust numerical methods for solving dynamical systems with multiple time scales. We first represent the solution of a multiscale dynamical system as a transformation of a slowly varying solution.
Hou, Thomas Y. +2 more
core +1 more source
Convex additively slowly varying functions
Journal of Mathematical Analysis and Applications, 2002 zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Janković, Slobodanka +1 more
openaire +1 more source
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
A Slowly Varying Spoofing Algorithm on Loosely Coupled GNSS/IMU Avoiding Multiple Anti-Spoofing Techniques. [PDF]
Sensors (Basel), 2022 Gao Y, Li G.
europepmc +1 more source
Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Gravity-driven draining of a thin rivulet with constant width down a slowly varying substrate [PDF]
, 2012 The locally unidirectional gravity-driven draining of a thin rivulet with constant width but slowly varying contact angle down a slowly varying substrate is considered.
Duffy, B. R. +2 more
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