Results 61 to 70 of about 6,925,642 (276)

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Holderian functional central limit theorem for linear processes

Lietuvos Matematikos Rinkinys, 2004
Let (Xt)t ≥ 1 be a linear process defined by Xt =  ∑i=0∞ψi εt-1 where (ψi, i ≥ 0) is a sequence of  real numbers and (εi , i ∈ Z) is a sequence of random variables with null expectation and variance 1.
Mindaugas Juodis
doaj   +3 more sources

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Controllability for Systems with Slowly Varying Parameters [PDF]

, 2003
For systems with slowly varying parameters the controllability behavior is studied and the relation to the control sets for the systems with frozen parameters is ...
Fritz Colonius, Colonius, Fritz, Fabbri, Roberta, Roberta Fabbri   +3 more
core   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Sound Propagation in Slowly Varying 2D Duct with Shear Flow [PDF]

, 2016
A slowly varying modes solution of WKB type is derived for the problem of sound propagation in a slowly varying 2D duct with linearly sheared mean flow.
Rienstra, S.W., Sjoerd W. Rienstra
core   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Bifurcation analysis of a paradigmatic model of monsoon prediction [PDF]

Nonlinear Processes in Geophysics, 2005
Local and global bifurcation structure of the forced Lorenz model in the r-F plane is investigated. The forced Lorenz model is a conceptual model for understanding the influence of the slowly varying boundary forcing like Sea Surface Temperature (SST) on
A. Kumar Mittal, A. Kumar Mittal, A. Kumar Mittal, S. Dwivedi, S. Dwivedi, S. Dwivedi, A. Chandra Pandey, A. Chandra Pandey, A. Chandra Pandey   +8 more
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