Results 91 to 100 of about 8,994,995 (387)

Neurochemical markers in CSF of adolescent and adult SMA patients undergoing nusinersen treatment

Therapeutic Advances in Neurological Disorders, 2019
Background: There is limited information on neurochemical markers being used to support and monitor the affection of motoneurons in patients with spinal muscular atrophy (SMA).
C. Wurster, R. Günther, P. Steinacker, J. Dreyhaupt, K. Wollinsky, Z. Uzelac, S. Witzel, T. Kocak, B. Winter, J. Koch, P. Lingor, S. Petri, A. Ludolph, A. Hermann, M. Otto   +14 more
semanticscholar   +1 more source

SMA - TREATMENT [PDF]

Neuromuscular Disorders, 2021
Roy, S., Anderson, F., Saito, K., Menier, M., Dabbous, O., Servais, L., LaMarca, N., Mercuri, E., Tizzano, E., De Vivo, D., Kirschner, Janbernd, Muntoni, F., Finkel, R.   +12 more
openaire   +4 more sources

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source

Escherichia fergusonii Promotes Nonobese Nonalcoholic Fatty Liver Disease by Interfering With Host Hepatic Lipid Metabolism Through Its Own msRNA 23487Summary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Gut microbiota and microbial factors regulate the pathogenesis of nonalcoholic fatty liver disease (NAFLD) in patients with obesity and metabolic abnormalities, but little is known about their roles in nonobese NAFLD.
Feng-Zhi Xin, Ze-Hua Zhao, Xiao-Lin Liu, Qin Pan, Zi-Xuan Wang, Lin Zeng, Qian-Ren Zhang, Lin Ye, Meng-Yu Wang, Rui-Nan Zhang, Zi-Zhen Gong, Lei-Jie Huang, Chao Sun, Feng Shen, Lu Jiang, Jian-Gao Fan   +15 more
doaj  

Magnetic and electronic properties of transition metal doped aluminium nitride: Haldane’s approach combined with ab initio results

AIP Advances, 2021
The electronic and magnetic properties of transition metal (Mn and Cr) doped Aluminium Nitride (AlN) in the wurtzite structure is studied using the single impurity Anderson model (SIAM) extended to semiconductors by Haldane.
Parvathy Harikumar, S. Mathi Jaya, Sharat Chandra   +2 more
doaj   +1 more source

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).

Journal of Medicinal Chemistry, 2018
Spinal muscular atrophy (SMA), a rare neuromuscular disorder, is the leading genetic cause of death in infants and toddlers. SMA is caused by the deletion or a loss of function mutation of the survival motor neuron 1 (SMN1) gene.
Atwood K Cheung, Brian Hurley, Ryan Kerrigan, Lei Shu, D. Chin, Yiping Shen, Gary O'Brien, M. Sung, Ying Hou, Jake Axford, Emma Cody, Robert Sun, A. Fazal, Cary Fridrich, C. Sánchez, R. Tomlinson, Monish Jain, Lin Deng, K. Hoffmaster, Cheng Song, Mailin Van Hoosear, Y. Shin, Rebecca Servais, C. Towler, M. Hild, D. Curtis, W. Dietrich, L. Hamann, K. Briner, Karen S. Chen, D. Kobayashi, Rajeev Sivasankaran, N. Dales   +32 more
semanticscholar   +1 more source

Interaction vesicles as emerging mediators of host‐pathogen molecular crosstalk and their implications for infection dynamics

FEBS Letters, EarlyView.
Interaction extracellular vesicles (iEVs) are hybrid vesicles formed through host‐pathogen communication. They facilitate immune evasion, transfer pathogens' molecules, increase host cell uptake, and enhance virulence. This Perspective article illustrates the multifunctional roles of iEVs and highlights their emerging relevance in infection dynamics ...
Bruna Sabatke, Izadora Volpato Rossi, Marcel I. Ramirez   +2 more
wiley   +1 more source

Temporal Transcript Profiling Identifies a Role for Unfolded Protein Stress in Human Gut Ischemia-Reperfusion InjurySummary

Cellular and Molecular Gastroenterology and Hepatology, 2022
Background & Aims: Intestinal ischemia-reperfusion injury is a serious and life-threatening condition. A better understanding of molecular mechanisms related to intestinal ischemia-reperfusion injury in human beings is imperative to find therapeutic ...
Anna M. Kip, Joep Grootjans, Marco Manca, M’hamed Hadfoune, Bas Boonen, Joep P.M. Derikx, Erik A.L. Biessen, Steven W.M. Olde Damink, Cornelis H.C. Dejong, Wim A. Buurman, Kaatje Lenaerts   +10 more
doaj  

New features of the triaxial nuclei described with a coherent state model

, 2011
Supplementing the Liquid Drop Model (LDM) Hamiltonian, written in the intrinsic reference frame, with a sextic oscillator plus a centrifugal term in the variable $\beta$ and a potential in $\gamma$ with a minimum in $\frac{\pi}{6}$, the Sch\"{o}dinger ...
A A Raduta, Amand Faessler, Bohr A, Bohr A, Casten R F, Fortunato L, P Buganu, Raduta A A, Raduta A A, Raduta A A, Rose M E, Thiamova G, Ushveridze A G   +12 more
core   +1 more source

Shared Medical Appointments: An Innovative Model to Reduce Health Disparities Among Latinxs With Type-2 Diabetes. [PDF]

, 2020
In the United States, diabetes is epidemic. A study of Latinxs with diabetes evaluated a behavioral shared medical appointment (SMA) intervention. This quasi-experimental study included nonrandomized matched control group participants receiving usual ...
Alkon, Abbey, Chesla, Catherine, Noya, Carolina Espinosa, Waters, Catherine   +3 more
core   +1 more source