Results 91 to 100 of about 9,502,534 (376)

A multi-source approach to determine SMA incidence and research ready population

Journal of Neurology, 2017
In spinal muscular atrophy (SMA), degeneration of motor neurons causes progressive muscular weakness, which is caused by homozygous deletion of the SMN1 gene.
I. Verhaart, A. Robertson, R. Leary, G. McMacken, Kirsten König, J. Kirschner, Cynthia C. Jones, Suzanne F. Cook, Hanns Lochmüller   +8 more
semanticscholar   +1 more source

Developmental Disorders in Children Recently Diagnosed With Cancer

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Neurocognitive deficits in adult survivors of childhood cancer are well established, but less is known about developmental disorders (DD) arising shortly after cancer diagnosis. Using 2016–2019 linked Ohio cancer registry and Medicaid data, we compared DD among 324 children with cancer and 606,913 cancer‐free controls.
Jamie Shoag, Long Vu, Ritika Miryala, Jeffrey M. Albert, Molly McVoy, Siran M. Koroukian   +5 more
wiley   +1 more source

DELP Treatment on Vision and Retinal Microcirculation in Patients With Acute Ischemic Stroke: Report of Five Cases and Literature Review

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background The delipid extracorporeal lipoprotein filter from plasma (DELP) treatment can effectively reduce blood lipid, increase blood flow, and improve neurological deficits in patients with acute ischemic stroke (AIS). However, its effect on vision and retinal microcirculation in stroke patients has never been reported.
Ning Li, Ronghua Hong, Hua You, Feiping Xu, Qingjun Zhang, Yiwen Lin, Yuting Su, Danmei Lan, Lingjing Jin, Junhui She   +9 more
wiley   +1 more source

Revised Hammersmith Scale for spinal muscular atrophy: A SMA specific clinical outcome assessment tool

PLoS ONE, 2017
Recent translational research developments in Spinal Muscular Atrophy (SMA), outcome measure design and demands from regulatory authorities require that clinical outcome assessments are ‘fit for purpose’.
D. Ramsey, M. Scoto, A. Mayhew, M. Main, E. Mazzone, J. Montes, R. de Sanctis, Sally Dunaway Young, R. Salazar, A. Glanzman, A. Pasternak, J. Quigley, Elizabeth Mirek, T. Duong, R. Gee, M. Civitello, G. Tennekoon, M. Pane, M. Pera, K. Bushby, J. Day, B. Darras, D. D. De Vivo, R. Finkel, E. Mercuri, F. Muntoni   +25 more
semanticscholar   +1 more source

A Comparative Study of Cerebral Oxygenation During Exercise in Hemodialysis and Peritoneal Dialysis Patients

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Cognitive impairment and exercise intolerance are common in dialysis patients. Cerebral perfusion and oxygenation play a major role in both cognitive function and exercise execution; HD session per se aggravates cerebral ischemia in this population. This study aimed to compare cerebral oxygenation and perfusion at rest and in mild
Marieta P. Theodorakopoulou, Konstantina Dipla, Danai Faitatzidou, Fotini Iatridi, Areti Georgiou, Artemios Karagiannidis, Erasmia Sampani, Chrysostomos Dimitriadis, Aggelos Koutlas, Andreas Zafeiridis, Pantelis Sarafidis   +10 more
wiley   +1 more source

HUBUNGAN ANTARA PERSEPSI SISWA TENTANG FASILITAS LABORATORIUM KOMPUTER DAN KEAKTIFAN BELAJAR SISWA DENGAN PRESTASI BELAJAR MATA PELAJARAN TEKNOLOGI INFORMASI DAN KOMUNIKASI (TIK) KELAS XI SMA NEGERI 1 GAMPING TAHUN AJARAN 2012/2013 [PDF]

, 2013
This research has the purpose (1) determine the relationship between student perceptions about the computer laboratory facilities with ICT learning achievement of grade XI students of SMA Negeri 1 Gamping academic year 2012/2013, (2) determine the ...
M. Zumar, Arifin
core  

Revealing the structure of land plant photosystem II: the journey from negative‐stain EM to cryo‐EM

FEBS Letters, EarlyView.
Advances in cryo‐EM have revealed the detailed structure of Photosystem II, a key protein complex driving photosynthesis. This review traces the journey from early low‐resolution images to high‐resolution models, highlighting how these discoveries deepen our understanding of light harvesting and energy conversion in plants.
Roman Kouřil
wiley   +1 more source

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).

Journal of Medicinal Chemistry, 2018
Spinal muscular atrophy (SMA), a rare neuromuscular disorder, is the leading genetic cause of death in infants and toddlers. SMA is caused by the deletion or a loss of function mutation of the survival motor neuron 1 (SMN1) gene.
Atwood K Cheung, Brian Hurley, Ryan Kerrigan, Lei Shu, D. Chin, Yiping Shen, Gary O'Brien, M. Sung, Ying Hou, Jake Axford, Emma Cody, Robert Sun, A. Fazal, Cary Fridrich, C. Sánchez, R. Tomlinson, Monish Jain, Lin Deng, K. Hoffmaster, Cheng Song, Mailin Van Hoosear, Y. Shin, Rebecca Servais, C. Towler, M. Hild, D. Curtis, W. Dietrich, L. Hamann, K. Briner, Karen S. Chen, D. Kobayashi, Rajeev Sivasankaran, N. Dales   +32 more
semanticscholar   +1 more source

Mapping the evolution of mitochondrial complex I through structural variation

FEBS Letters, EarlyView.
Respiratory complex I (CI) is crucial for bioenergetic metabolism in many prokaryotes and eukaryotes. It is composed of a conserved set of core subunits and additional accessory subunits that vary depending on the organism. Here, we categorize CI subunits from available structures to map the evolution of CI across eukaryotes. Respiratory complex I (CI)
Dong‐Woo Shin, Tingting Chen, James A. Letts   +2 more
wiley   +1 more source

Bidirectional Adaptation of Shared Autonomous Vehicles and Old Towns’ Urban Spaces: The Views of Residents on the Present

World Electric Vehicle Journal
The integration of shared autonomous vehicles into historic urban areas presents both opportunities and challenges. In heritage-rich environments like very old Asian (such as Suzhou old town, which serves as a use case example) or European (especially ...
Sucheng Yao, Kanjanee Budthimedhee, Sakol Teeravarunyou, Xinhao Chen, Ziqiang Zhang   +4 more
doaj   +1 more source