Results 91 to 100 of about 9,546,471 (324)

Newborn screening for SMA in Southern Belgium.

Neuromuscular Disorders, 2019
Approval was recently granted for a new treatment for spinal muscular atrophy (SMA). Given that the treatment is effective when administered early and the societal burden of SMA-related disability, the implementation of a newborn screening program is ...
F. Boemer, J. Caberg, V. Dideberg, Domien Dardenne, V. Bours, M. Hiligsmann, T. Dangouloff, L. Servais   +7 more
semanticscholar   +1 more source

Rapid Response to Trametinib Combined With Chemotherapy for Infant BRAF‐Fused Chiasmatic Glioma

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Infants, less than 1 year, with chiasmatic gliomas (ICG) present a major therapeutic challenge due to large tumor size, decreased vision, rapid progression, and poor response to vincristine/carboplatin chemotherapy. The majority have a BRAF fusion, which may respond to downstream MEK inhibitors but response time is slow. There are no safety or
Helen Toledano, Alexander Yelak, Walid Kaadan, Shlomo Caduri, Rivka Friedland, Orli Michaeli, Gad Dotan, Osnat Konen   +7 more
wiley   +1 more source

Iron-based shape memory alloy (Fe-SMA) for fatigue strengthening of cracked steel bridge connections

Construction and Building Materials, 2019
Smart iron-based shape memory alloys (Fe-SMAs) are used in this study to retrofit fatigue-cracked riveted connections in steel bridges. The prestressed strengthening technique is found to be an effective approach to overcome fatigue-related damage in ...
M. Izadi, M. Motavalli, E. Ghafoori
semanticscholar   +1 more source

A shape memory alloy adaptive tuned vibration absorber: design and implementation

, 2005
In this paper a tuned vibration absorber (TVA) is realized using shape memory alloy (SMA) elements. The elastic modulus of SMA changes with temperature and this effect is exploited to develop a continuously tunable device.A TVA with beam elements is ...
Brennan, M.J., Mace, B.R., Rustighi, E.
core   +1 more source

A PRSZT Registry Analysis of Prognostic Factors Influencing Survival and Relapse Rates After Second Allogeneic Hematopoietic Stem Cell Transplantation in Pediatric Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT A second allogeneic (allo‐)hematopoietic stem cell transplantation (HSCT2) is a potential curative option for pediatric patients with acute lymphoblastic leukemia (ALL) following relapse after first allogeneic transplantation (HSCT1), but its efficacy is limited by high relapse rates and transplant‐related toxicity in highly pretreated ...
Ava Momm, Imme Haubitz, Rita Beier, Martin Zimmermann, Andrej Lissat, Peter Bader, Matthias Eyrich, Jan‐Henning Klusmann, Matthias Wölfl, Paul‐Gerhardt Schlegel, Verena Wiegering   +10 more
wiley   +1 more source

Evaluation of the Utility of Baseline Echocardiogram in Patients With Standard Risk Precursor B‐Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
Abstract Background A routine baseline echocardiogram is often obtained prior to anthracycline administration in children with cancer. The utility of baseline echocardiogram is unclear in patients with standard risk B‐cell acute lymphoblastic leukemia (SR B‐ALL) as their anthracycline cumulative dose is low.
Ziyad Alrajhi, Alice Pozza, Luc Mertens, Adam Paul Yan, Sarah Alexander   +4 more
wiley   +1 more source

Evaluation of Children with SMA Type 1 Under Treatment with Nusinersen within the Expanded Access Program in Germany

Journal of Neuromuscular Diseases, 2018
Background: Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by muscle weakness and muscle atrophy. Nusinersen acts as a splicing modifier and has recently been approved for intrathecal treatment of SMA.
A. Pechmann, T. Langer, D. Schorling, S. Stein, Sibylle Vogt, U. Schara, H. Kölbel, O. Schwartz, A. Hahn, Kerstin Giese, J. Johannsen, J. Denecke, C. Weiss, M. Theophil, J. Kirschner   +14 more
semanticscholar   +1 more source

Explicit finite element implementation of a shape memory alloy constitutive model and associated analyses [PDF]

, 2017
Shape memory alloys (SMA) represent an important class of smart metallic materials employed in various innovative applications thanks to their unique thermomechanical behavior.
Auricchio, F., Boatti, E., Ferraro, M., Hartl, D.J., Mercuri, V., Scalet, G.   +5 more
core  

Intraoperative Collection of Ascitic Fluid With Intra‐ or Postoperative Reinfusion in Ovarian Cancer: Safety and Feasibility of a Roller Pumping Method

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Patients with ovarian cancer often present with massive ascites, leading to significant protein loss during surgical procedures. Although cell‐free concentrated ascites reinfusion therapy (CART) is used in palliative settings to mitigate protein loss, its application in intraoperative settings remains unexplored.
Yutaka Yoneoka, Tsukuru Amano, Akimasa Takahashi, Mari Deguchi, Hiroyuki Yamanaka, Yuji Tanaka, Shunichiro Tsuji, Takashi Murakami   +7 more
wiley   +1 more source

The clinical landscape for SMA in a new therapeutic era

Gene Therapy, 2017
Despite significant advances in basic research, the treatment of degenerative diseases of the nervous system remains one of the greatest challenges for translational medicine.
K. Talbot, E. Tizzano
semanticscholar   +1 more source