Results 101 to 110 of about 8,011,267 (345)
Ion channel function of polycystin‐2/polycystin‐1 heteromer revealed by structure‐guided mutagenesis
FEBS Letters, EarlyView.Mutations in polycystin‐1 (PC1) or polycystin‐2 (PC2) cause autosomal‐dominant polycystic kidney disease (ADPKD). We generated a novel gain‐of‐function PC2/PC1 heteromeric ion channel by mutating pore‐blocking residues. Moreover, we demonstrated that PC2 will preferentially assemble with PC1 to form heteromeric complexes when PC1 is co‐expressed ...
Tobias Staudner +7 more
wiley +1 more source
Characterization of a murine model of SMA
Neurobiology of Disease, 2012 Spinal muscular atrophy (SMA) is an autosomal recessive neuromuscular disease, which is the leading genetic cause of mortality in children. To date no effective treatment exists for SMA. The genetic basis for SMA has been well documented as a mutation in the gene for survival of motor neuron (SMN).
Brenten L. Heeke +8 more
openaire +4 more sources
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Podocyte-derived microparticles promote proximal tubule fibrotic signaling via p38 MAPK and CD36
Journal of Extracellular Vesicles, 2018 Tubulointerstitial fibrosis is a hallmark of advanced diabetic kidney disease that is linked to a decline in renal function, however the pathogenic mechanisms are poorly understood.
Mercedes N. Munkonda +10 more
doaj +1 more source
Development of Faster SMA Actuators
, 2017 Le temps de cycle important, résultant d'un refroidissement lent, est le principal obstacle aux applications à grande échelle des alliages à mémoire de forme (SMA) en tant qu'actionneurs. Ce chapitre traite d'une nouvelle technique de refroidissement pour réduire le temps de cycle des SMA.
Atta Muhammad Nizamani +2 more
openaire +3 more sources
SMA actuators for morphing wings
Physics Procedia, 2010 AbstractAn experimental morphing laminar wing was developed to prove the feasibility of aircraft fuel consumption reduction through enhancement of the laminar flow regime over the wing extrados. The morphing wing prototype designed for subsonic cruise flight conditions (Mach 0.2…0.3; angle of attack −1…+2∘), combines three principal subsystems: (1 ...
Daniel Coutu +3 more
openaire +2 more sources
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Serum Glutamic Oxalacetic Transaminase Assay Using the Sequential Multiple Analyzer (SMA 12/30) [PDF]
, 1969 John J. Moore, Sylvan M Sax
openalex +1 more source
SMA Actuator with Active Clamp
Procedia Engineering, 2012 AbstractThe paper deals with modeling and simulation of the Shape Memory Alloy (SMA) actuator for mechatronic systems. The thermal actuator made of Nickel–Titanium (NiTi) wire and new active clamp are heated by electric resistance heating and naturally air-cooled. The paper addresses FEM electro thermal simulation of NiTi actuator with special shape of
Vladimír Kutiš +2 more
openaire +2 more sources