Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy
Human Molecular Genetics, 2018 Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of &agr;‐motor neurons, leading to profound skeletal muscle atrophy. Patients also suffer from decreased bone mineral density and increased fracture risk.
K. Long +11 more
semanticscholar +1 more source
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
Hepatic TM6SF2 Is Required for Lipidation of VLDL in a Pre-Golgi Compartment in Mice and RatsSummary
Cellular and Molecular Gastroenterology and Hepatology, 2022 Background & Aims: Substitution of lysine for glutamic acid at residu 167 in Transmembrane 6 superfamily member 2 (TM6SF2) is associated with fatty liver disease and reduced plasma lipid levels.
Fei Luo +8 more
doaj
On the single mode approximation in spinor-1 atomic condensate
, 2002 We investigate the validity conditions of the single mode approximation (SMA) in spinor-1 atomic condensate when effects due to residual magnetic fields are negligible. For atomic interactions of the ferromagnetic type, the SMA is shown to be exact, with
A. Crubellier +34 more
core +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Acta Scientiarum: Animal Sciences, 2013 The aim of the present work was to answer the following question: can a small change in the tilapia’s on-going feeding strategy impair its growth? In the initial phase of the study, fish were evenly distributed and maintained for two weeks in four tanks.
Nayara Nunes Caldini +3 more
doaj +1 more source
The effectiveness of styrene-maleic acid (SMA) copolymers for solubilisation of integral membrane proteins from SMA-accessible and SMA-resistant membranes [PDF]
Biochimica et Biophysica Acta (BBA) - Biomembranes, 2017 Solubilisation of biological lipid bilayer membranes for analysis of their protein complement has traditionally been carried out using detergents, but there is increasing interest in the use of amphiphilic copolymers such as styrene maleic acid (SMA) for the solubilisation, purification and characterisation of integral membrane proteins in the form of ...
Swainsbury, D.J.K. +5 more
openaire +8 more sources
A stepwise emergence of evolution in the RNA world
FEBS Letters, EarlyView.How did biological evolution emerge from chemical reactions? This perspective proposes a gradual scenario of self‐organization among RNA molecules, where catalytic feedback on random mixtures plays the central role. Short oligomers cross‐ligate, and self‐assembly enables heritable variations. An event of template‐externalization marks the transition to
Philippe Nghe
wiley +1 more source
Liquid-phase preparation of BaTiO(3) nanoparticles
IET Nanodielectrics, 2020 Barium titanate (BaTiO(3), BT) is widely used in the manufacture of electronic components such as multilayer ceramic capacitors, supercapacitors, thermistors, ferroelectric devices and piezoelectric devices due to its excellent dielectric, ferroelectric,
Feng Shi +3 more
doaj +1 more source
HUBUNGAN ANTARA PERSEPSI SISWA TENTANG FASILITAS LABORATORIUM KOMPUTER DAN KEAKTIFAN BELAJAR SISWA DENGAN PRESTASI BELAJAR MATA PELAJARAN TEKNOLOGI INFORMASI DAN KOMUNIKASI (TIK) KELAS XI SMA NEGERI 1 GAMPING TAHUN AJARAN 2012/2013 [PDF]
, 2013 This research has the purpose (1) determine the relationship between student perceptions about the computer laboratory facilities with ICT learning achievement of grade XI students of SMA Negeri 1 Gamping academic year 2012/2013, (2) determine the ...
M. Zumar, Arifin
core