Results 111 to 120 of about 9,546,471 (324)

High Spatial Resolution Observations of Two Young Protostars in the R Corona Australis Region

, 2007
We present multi-wavelength, high spatial resolution imaging of the IRS 7 region in the R Corona Australis molecular cloud. Our observations include 1.1 mm continuum and HCO^+ J = $3 \to 2$ images from the SMA, ^{12}CO J = $3 \to 2$ outflow maps from the
Christopher E. Groppi, Goran Sandell, Harju J., Henning T., Hildebrand R. H., Knude J., Koyama K., Raymond Blundell, Taylor K. N. R., Todd R. Hunter   +9 more
core   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

A multi-source approach to determine SMA incidence and research ready population

Journal of Neurology, 2017
In spinal muscular atrophy (SMA), degeneration of motor neurons causes progressive muscular weakness, which is caused by homozygous deletion of the SMN1 gene.
I. Verhaart, A. Robertson, R. Leary, G. McMacken, Kirsten König, J. Kirschner, Cynthia C. Jones, Suzanne F. Cook, Hanns Lochmüller   +8 more
semanticscholar   +1 more source

Implementing Spatial Intelligence-Based Respond Method in the Physics Instruction to Improve Physics Learning Outcomes on the Lesson Subject of Straight Motion of the Tenth Grade Students of SMA N 1 Jogolagan in the First Semester [PDF]

, 2010
This study aims at determining influences of the spatial intelligence-based respond method towards physics learning outcomes on the subject of straight motion of the students of Grade X of SMA N 1 Jogonalan. This research also aims at determining whether
WINARKO ARGI PRAMONO, -
core  

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Revised Hammersmith Scale for spinal muscular atrophy: A SMA specific clinical outcome assessment tool

PLoS ONE, 2017
Recent translational research developments in Spinal Muscular Atrophy (SMA), outcome measure design and demands from regulatory authorities require that clinical outcome assessments are ‘fit for purpose’.
D. Ramsey, M. Scoto, A. Mayhew, M. Main, E. Mazzone, J. Montes, R. de Sanctis, S. Dunaway Young, R. Salazar, A. Glanzman, A. Pasternak, Janet Quigley, Elizabeth Mirek, T. Duong, R. Gee, M. Civitello, G. Tennekoon, M. Pane, M. Pera, K. Bushby, J. Day, B. Darras, D. D. De Vivo, R. Finkel, E. Mercuri, F. Muntoni   +25 more
semanticscholar   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Specific inhibition of myostatin activation is beneficial in mouse models of SMA therapy

Human Molecular Genetics, 2018
Spinal muscular atrophy (SMA) is a neuromuscular disease characterized by loss of &agr;‐motor neurons, leading to profound skeletal muscle atrophy. Patients also suffer from decreased bone mineral density and increased fracture risk.
K. Long, Karen M. O’Shea, R. Khairallah, Kelly Howell, S. Paushkin, Karen S. Chen, S. Cote, Micah T Webster, J. Stains, E. Treece, A. Buckler, A. Donovan   +11 more
semanticscholar   +1 more source

Spatiotemporal and quantitative analyses of phosphoinositides – fluorescent probe—and mass spectrometry‐based approaches

FEBS Letters, EarlyView.
Fluorescent probes allow dynamic visualization of phosphoinositides in living cells (left), whereas mass spectrometry provides high‐sensitivity, isomer‐resolved quantitation (right). Their synergistic use captures complementary aspects of lipid signaling. This review illustrates how these approaches reveal the spatiotemporal regulation and quantitative
Hiroaki Kajiho, Shin Morioka, Junko Sasaki, Takehiko Sasaki   +3 more
wiley   +1 more source

Discovery of Small Molecule Splicing Modulators of Survival Motor Neuron-2 (SMN2) for the Treatment of Spinal Muscular Atrophy (SMA).

Journal of Medicinal Chemistry, 2018
Spinal muscular atrophy (SMA), a rare neuromuscular disorder, is the leading genetic cause of death in infants and toddlers. SMA is caused by the deletion or a loss of function mutation of the survival motor neuron 1 (SMN1) gene.
Atwood K Cheung, B. Hurley, Ryan Kerrigan, Lei Shu, D. Chin, Yiping Shen, Gary O'Brien, M. Sung, Ying Hou, Jake Axford, Emma Cody, Robert Sun, A. Fazal, Cary Fridrich, C. Sánchez, R. Tomlinson, Monish Jain, Lin Deng, K. Hoffmaster, Cheng Song, Mailin Van Hoosear, Y. Shin, Rebecca Servais, C. Towler, M. Hild, Daniel Curtis, W. Dietrich, L. Hamann, K. Briner, Karen S. Chen, D. Kobayashi, Rajeev Sivasankaran, N. Dales   +32 more
semanticscholar   +1 more source