Results 11 to 20 of about 9,380,370 (380)

Abnormal motoneuron migration, differentiation, and axon outgrowth in spinal muscular atrophy [PDF]

, 2008
The role of heterotopic (migratory) motoneurons (HMN) in the pathogenesis of spinal muscular atrophy (SMA) is still controversial. We examined the occurrence and amount of HMN in spinal cord tissue from eight children with SMA (six with SMA-I and two ...
Barišić, Nina, Hof, Patrick R., Islam, Atiqul, Jovanov Milošević, Nataša, Krušlin, Božo, Lucassen, Paul J., Mladinov, Mihovil, Pajtak, Alen, Sertić, Jadranka, Šešo Šimić, Đurđica, Šimić, Goran   +10 more
core   +1 more source

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA).

Journal of Medicinal Chemistry, 2018
SMA is an inherited disease that leads to loss of motor function and ambulation and a reduced life expectancy. We have been working to develop orally administrated, systemically distributed small molecules to increase levels of functional SMN protein ...
H. Ratni, M. Ebeling, J. Baird, Stefanie Bendels, J. Bylund, Karen S. Chen, Nora Denk, Zhihua Feng, Luke Green, M. Guérard, P. Jablonski, B. Jacobsen, O. Khwaja, Heidemarie Kletzl, C. Ko, S. Kustermann, A. Marquet, F. Metzger, Barbara Mueller, N. Naryshkin, S. Paushkin, E. Pinard, A. Poirier, M. Reutlinger, M. Weetall, A. Zeller, Xin Zhao, Lutz Mueller   +27 more
semanticscholar   +1 more source

Fungal colonization of the roots of selected halophytes from Sečovlje salterns

Acta Biologica Slovenica, 2007
To reveal their mycotrophic status, we have here analysed the fungal colonisation of the roots, and the identity of these fungi, of the most abundant halophytic plant species from Sečovlje salterns (Slovenia): Aster tripolium, Limonium angustifolium and
Silva Sonjak, Tamara Glavina, Metka Udovič, Marjana Regvar   +3 more
doaj   +1 more source

Effect of Pre-oxidation on Coal Specific Surface Area and Pore Size Distribution

Meikuang Anquan, 2020
In order to explore the micro structure variation features of coal after pre-oxidation, the liquid nitrogen adsorption experiment was adopted to measure the specific surface area and pore structure of Liujia lignite, Sitai lignite, Tongxin bituminous ...
SUN Yong
doaj   +1 more source

Anion-exchange chromatography using CIM® DEAE disks as a method of choice for DNA isolation from lecithin

Acta Biologica Slovenica, 2007
The most important prerequisite for the application of PCR-based methods, among them the detection and quantifi cation of genetically modifi ed organisms (GMOs) is the ability to extract significant amounts of DNA of adequate quality from the sample ...
Špela Höfferle, Ana Kramar, Franc Smrekar, Dejan Štebih, Jana Vojvoda, Jana Žel, Peter Raspor   +6 more
doaj   +1 more source

α-Smooth muscle actin expression in cancerassociated fibroblasts in canine epithelial tumors [PDF]

, 2017
Tumor tissues contain not only cancer cells but also other cell types including, fibroblasts, immune cells, and endothelial cells, which interact with cancer cells.
Hoshino, Yuki, Izumi, Yusuke, Takagi, Satoshi, Yoshimoto, Sho   +3 more
core   +1 more source

Micro-business participation in collective flood adaptation: lessons from scenario-based analysis in Ho Chi Minh City, Vietnam [PDF]

Natural Hazards and Earth System Sciences
Although research on the impacts of climate change on small- and medium-sized enterprises (SMEs) and their adaptation to climate change risks has recently received more attention, the focus on micro-businesses and household businesses is still very ...
J. Revilla Diez, R. Leitold, V. Tran, M. Garschagen   +3 more
doaj   +1 more source

Natural history of Type 2 and 3 spinal muscular atrophy: 2‐year NatHis‐SMA study

Annals of Clinical and Translational Neurology, 2020
To characterize the natural history of spinal muscular atrophy (SMA) over 24 months using innovative measures such as wearable devices, and to provide evidence for the sensitivity of these measures to determine their suitability as endpoints in clinical ...
M. Annoussamy, A. Seferian, A. Daron, Y. Péréon, C. Cances, C. Vuillerot, L. De Waele, V. Laugel, U. Schara, T. Gidaro, C. Lilien, J. Hogrel, P. Carlier, E. Fournier, L. Lowes, K. Gorni, Myriam Ly-Le Moal, N. Hellbach, T. Seabrook, C. Czech, R. Hermosilla, L. Servais   +21 more
semanticscholar   +1 more source

A hydro-acoustics approach of accessing macrophyte biomass data

Acta Biologica Slovenica, 2010
Hydro-acoustic methods are commonly used to estimate the abundance and distribution pattern of fish in aquatic environments, while studies on the assessment of the biomass of submerged macrophytes in the littoral zones are still rare. In the present study
Norbert Exler, Georg Janauer
doaj   +1 more source

Gastric perforation and pancreatitis manifesting after an inadvertent nissen fundoplication in a patient with superior mesenteric artery syndrome. [PDF]

, 2009
Superior mesenteric artery (SMA) syndrome is an uncommon but well-recognized clinical entity. It can lead to proximal small bowel obstruction and severe morbidity and mortality in lieu of late diagnosis and concomitant existing comorbidities. We report a
Estrada, JJ, Giuliani, S, Mason, RJ, Petrosyan, M, Rosen, H, Williams, M   +5 more
core   +3 more sources