Results 11 to 20 of about 8,159,171 (345)

Shape Memory Alloy (SMA) Actuators: The Role of Material, Form, and Scaling Effects

Advances in Materials, 2023
Shape memory alloys (SMAs) are smart materials that are widely used to create intelligent devices because of their high energy density, actuation strain, and biocompatibility characteristics.
Min‐Soo Kim, J. Heo, H. Rodrigue, Hyun-Taek Lee, S. Pané, Min-Woo Han, Sung-hoon Ahn   +6 more
semanticscholar   +1 more source

Gene Therapy for Spinal Muscular Atrophy (SMA): A Review of Current Challenges and Safety Considerations for Onasemnogene Abeparvovec (Zolgensma)

Cureus, 2023
Spinal Muscular Atrophy (SMA) is a genetic disease that causes weakness and wasting in the voluntary muscles of infants and children. SMA has been the leading inherited cause of infant death.
Tolu Ogbonmide, Rajni Rathore, S. Rangrej, Stedrea Hutchinson, Marcia Lewis, Stephenie Ojilere, Victoria Carvalho, Irenaissia Kelly   +7 more
semanticscholar   +1 more source

Impaired prenatal motor axon development necessitates early therapeutic intervention in severe SMA

Science Translational Medicine, 2021
Fetal delays of SMA motor axon radial growth coupled with rapid postnatal degeneration require very early delivery of SMN induction treatments. The sooner, the better Gene therapy approaches hold promise for the treatment of spinal muscular atrophy (SMA).
L. Kong, D. Valdivia, C. Simon, Cera W. Hassinan, N. Delestrée, Daniel M. Ramos, J. Park, Celeste M. Pilato, Xixi Xu, Melissa E. Crowder, Chloe C. Grzyb, Zachary A. King, M. Petrillo, K. Swoboda, Crystal Davis, C. Lutz, Alexander H. Stephan, Xin Zhao, M. Weetall, N. Naryshkin, T. Crawford, G. Mentis, C. Sumner   +22 more
semanticscholar   +1 more source

Hysteretic response and failure behavior of an SMA cable‐based self‐centering brace

Structural Control & Health Monitoring, 2021
This study explores the experimental response and failure behavior of an SMA cable brace. The kernel of the developed SMA brace consists of four SMA cables with a diameter of 8 mm.
F. Shi, Yun Zhou, O. Ozbulut, F. Ren
semanticscholar   +1 more source

“I have SMA, SMA doesn’t have me”: a qualitative snapshot into the challenges, successes, and quality of life of adolescents and young adults with SMA

Orphanet Journal of Rare Diseases, 2021
Background With the approval of three treatments for spinal muscular atrophy (SMA) and several promising therapies on the horizon, the SMA adolescent and young adult populations are expected to evolve in the coming years.
Allison Mazzella, M. Curry, L. Belter, R. Cruz, J. Jarecki   +4 more
semanticscholar   +1 more source

Behavior and application of self-centering dampers equipped with buckling-restrained SMA bars

Smart materials and structures (Print), 2020
This study proposes a new type of self-centering damper equipped with novel buckling-restrained superelastic shape memory alloy (SMA) bars. The new solution aims to address some critical issues related to degradation and loss of superelasticity observed ...
C. Qiu, Cheng Fang, D. Liang, Xiu-li Du, M. Yam   +4 more
semanticscholar   +1 more source

Discovery of Risdiplam, a Selective Survival of Motor Neuron-2 ( SMN2) Gene Splicing Modifier for the Treatment of Spinal Muscular Atrophy (SMA).

Journal of Medicinal Chemistry, 2018
SMA is an inherited disease that leads to loss of motor function and ambulation and a reduced life expectancy. We have been working to develop orally administrated, systemically distributed small molecules to increase levels of functional SMN protein ...
H. Ratni, M. Ebeling, J. Baird, Stefanie Bendels, J. Bylund, Karen S. Chen, Nora Denk, Zhihua Feng, Luke Green, M. Guérard, P. Jablonski, B. Jacobsen, O. Khwaja, H. Kletzl, C. Ko, S. Kustermann, A. Marquet, F. Metzger, Barbara Mueller, N. Naryshkin, S. Paushkin, E. Pinard, A. Poirier, M. Reutlinger, M. Weetall, A. Zeller, Xin Zhao, Lutz Mueller   +27 more
semanticscholar   +1 more source

Pengembangan modul elektronik (e-modul) interaktif pada mata pelajaran Kimia kelas XI SMA

Jurnal Inovasi Teknologi Pendidikan, 2018
Penelitian ini bertujuan untuk: (1) menghasilkan produk e-modul interaktif pada mata pelajaran Kimia kelas  XI IPA SMA, (2) mengetahui tingkat kelayakan produk e-modul interaktif pada mata pelajaran Kimia kelas XI IPA SMA,dan (3) mengetahui efektivitas ...
N. Herawati, Ali Muhtadi
semanticscholar   +1 more source

Changes in Native Sentence Processing Related to Bilingualism: A Systematic Review and Meta-Analysis

Frontiers in Psychology, 2022
The native language changes as a result of contact with a second language, and the pattern and degree of such change depend on a variety of factors like the bilingual experience or the linguistic level.
Patricia Román, Patricia Román, Irene Gómez-Gómez   +2 more
doaj   +1 more source

Safety and Treatment Effects of Nusinersen in Longstanding Adult 5q-SMA Type 3 – A Prospective Observational Study

Journal of Neuromuscular Diseases, 2019
Objective: Spinal muscular atrophy (SMA) is a progressive autosomal recessive motor neuron disease caused by loss of the SMN1 gene. Based on randomized clinical trials in children with SMA type 1 and 2, Nusinersen has been approved as the first treatment
M. Walter, S. Wenninger, S. Thiele, J. Stauber, M. Hiebeler, E. Greckl, K. Stahl, A. Pechmann, H. Lochmüller, J. Kirschner, B. Schoser   +10 more
semanticscholar   +1 more source