Results 191 to 200 of about 9,380,370 (380)

Patient‐specific pharmacogenomics demonstrates xCT as predictive therapeutic target in colon cancer with possible implications in tumor connectivity

Molecular Oncology, EarlyView.
This study integrates transcriptomic profiling of matched tumor and healthy tissues from 32 colorectal cancer patients with functional validation in patient‐derived organoids, revealing dysregulated metabolic programs driven by overexpressed xCT (SLC7A11) and SLC3A2, identifying an oncogenic cystine/glutamate transporter signature linked to ...
Marco Strecker, Keren Zohar, Martin Böttcher, Thomas Wartmann, Henry Freudenstein, Maximilian Doelling, Mihailo Andric, Wenjie Shi, Or Kakhlon, Katrin Hippe, Beatrix Jahnke, Dimitrios Mougiakakos, Franziska Baenke, Daniel Stange, Roland S. Croner, Michal Linial, Ulf D. Kahlert   +16 more
wiley   +1 more source

Unlocking digital growth: overcoming barriers to digital transformation for Indian food SMEs

Discover Food
This paper aims to study how firms must be agile to overcome risks and manage cost repercussions. Specifically, it focuses on promoting digitalization in Indian food SMEs for greater competitiveness. The main purpose is to design a model for implementing
Sumit Gupta, Sandeep Jagtap
doaj   +1 more source

Pengaruh Penerapan Model Pembelajaran Kooperatif Tipe Teams Games Tournament (TGT) Terhadap Hasil Belajar Biologi Pada Materi Keanekaragaman Hayati Di SMA Negeri 1 Batang Hari

, 2019
Vinanda Zulfira, Evita Anggereini, Ali Sadikin   +2 more
openalex   +2 more sources

Reward Found in Synchronous Teaching English at SMA Muhammadiyah Malang

, 2023
Sri Nur Hartiningsih, Rahmawati Khadijah Maro, Miftahul Hamim, Royan Jamil Syauqi, Dea Triana Devy   +4 more
openalex   +2 more sources

Predictors of response and rational combinations for the novel MCL‐1 inhibitor MIK665 in acute myeloid leukemia

Molecular Oncology, EarlyView.
This study characterizes the responses of primary acute myeloid leukemia (AML) patient samples to the MCL‐1 inhibitor MIK665. The results revealed that monocytic differentiation is associated with MIK665 sensitivity. Conversely, elevated ABCB1 expression is a potential biomarker of resistance to the treatment, which can be overcome by the combination ...
Joseph Saad, Rhiannon Newman, Elmira Khabusheva, Sofia Aakko, Eric Durand, Mahesh Tambe, Heikki Kuusanmäki, Alun Parsons, Juho J. Miettinen, Komal Kumar Javarappa, Ezgi June Olgac, Nemo Ikonen, Mika Kontro, Kimmo Porkka, Heiko Maacke, Janghee Woo, Ensar Halilovic, Caroline A. Heckman   +17 more
wiley   +1 more source

Prognostic and clinicopathological significance of tertiary lymphoid structure in non-small cell lung cancer: a systematic review and meta-analysis

BMC Cancer
Background Non-small cell lung cancer (NSCLC) is the primary reason for cancer-related deaths globally. Tertiary lymphoid structure (TLS) is an organized collection of immune cells acquired in non-physiological, non-lymphoid tissues.
Luyuan Ma, Rongyang Li, Xiaomeng Liu, Wenhao Yu, Zhanpeng Tang, Yi Shen, Hui Tian   +6 more
doaj   +1 more source

Pengembangan Kegiatan MINI-LAB pada Topik Ekologi dan Lingkungan Untuk Siswa Kelas X SMA

, 2017
Verronicha Crysty, Binari Manurung, Syarifuddin Syarifuddin   +2 more
openalex   +2 more sources

Feasibility of a ctDNA multigenic panel for non‐small‐cell lung cancer early detection and disease surveillance

Molecular Oncology, EarlyView.
Plasma‐based detection of actionable mutations is a promising approach in lung cancer management. Analysis of ctDNA with a multigene NGS panel identified TP53, KRAS, and EGFR as the most frequently altered, with TP53 and KRAS in treatment‐naïve patients and TP53 and EGFR in previously treated patients.
Giovanna Maria Stanfoca Casagrande, Marcela de Oliveira Silva, Mariana Bisarro dos Reis, Rodrigo de Oliveira Cavagna, Luciane Sussuchi, Icaro Alves Pinto, Natalia Zampieri Pontes, Rodrigo Sampaio Chiarantano, Flavio Augusto Ferreira da Silva, Pedro de Marchi, Letícia Ferro Leal, Rui M. Reis   +11 more
wiley   +1 more source

Pengembangan Media Sebaon (Sepakbola Basis Online) untuk Pembelajaran Sepakbola Kelas X SMA N 1 Bojong Kabupaten Pekalongan

, 2022
Muhammad Rofi'ul Huda, Agus Widodo Suripto   +1 more
openalex   +2 more sources

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source