Results 271 to 280 of about 9,546,471 (324)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source

Detection of Copy-Number Variations in CNS Tumours From Off-Target Reads of Hybrid-Capture Sequencing. [PDF]

Neuropathol Appl Neurobiol
Schnorrenberg J, Adrian YL, Schlathölter J, Ruckert C, Horvath J, Paulus W, Hasselblatt M, Thomas C.   +7 more
europepmc   +1 more source

SMA

, 2012
openaire   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

Molecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova, Michele Montrone, Uday Rangaswamy, Francesco Diversi, Irene Schiavo, Denise Ferrarini, Roberta Di Florio, Irene Longo, Michele Coscia, Nicola Zamboni, Giorgia Demontis, Lisa Veghini, Vincenzo Corbo, Remo Sanges, Paul Heppenstall   +14 more
wiley   +1 more source

The Role of Communication in Romantic Attachment and Relationship Satisfaction: A Dyadic Longitudinal Study. [PDF]

J Marital Fam Ther
Lefebvre AA, Brassard A, Jean M, Daspe MÈ, Lafontaine MF, Péloquin K.   +5 more
europepmc   +1 more source

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Neuromuscular Block and Video Laryngoscope to Facilitate Intubation-A Survey of Current Practice in Denmark and Sweden. [PDF]

Acta Anaesthesiol Scand
Lodenius Å, Holland-Bill L, Ipsen EØ, Cronhjort M, Afshari A, Vested M, Creutzburg A, Lundstrøm LH, Nedergaard HK, Nørskov AK, ROCVIDEO Survey Collaborator Group.   +10 more
europepmc   +1 more source

Graft and Patient Survival After Liver Transplantation for Primary Sclerosing Cholangitis: A French National Cohort Study. [PDF]

Liver Int
Veyre F, Francoz C, Erard D, DeMartin E, Elkrief L, Besch C, Boillot O, Conti F, Dharancy S, Duvoux C, Gugenheim J, Hardwigsen J, Hilleret MN, Leroy V, Ollivier-Hourmand I, Gratien M, Houssel-Debry P, Kamar N, Roux O, Hiriart JB, Irles-Depe M, Pellegrin S, Durand F, Pageaux GP, Faure S, Coilly A, Radenne S, Saliba F, Samuel D, Vanlemmens C, Latournerie M, Boudjema K, Salamé E, Chazouillères O, Corpechot C, Dumortier J.   +35 more
europepmc   +1 more source

Clinical Use and Application of Neutropenic Diets for Patients With Cancer: A Cross-Sectional Survey of Dietitians in Australian Hospitals. [PDF]

J Hum Nutr Diet
Gulliver T, Hewett M, Konstantopoulos P, Tran L, Mantzioris E.   +4 more
europepmc   +1 more source

Enablers of community-led action in Australian climate disasters: recognising the role of pre-existing social foundations and local knowledges. [PDF]

Disasters
Webster S, Schlosberg D, Longman J, Pittaway E, Gillies-Palmer Z, Verlie B, Bailie J, Celermajer D, Howard A, Matous P, Naderpajouh N, Viney G, Iveson K, Joseph P, Rawsthorne M, Troy J.   +15 more
europepmc   +1 more source