Results 51 to 60 of about 9,380,370 (380)

Biophysical analysis of angiotensin II and amyloid‐β cross‐interaction in aggregation and membrane disruption

FEBS Letters, EarlyView.
Angiotensin II (AngII), a neuropeptide, interacts with amyloid‐β (Aβ), a key player in Alzheimer's disease. This study reveals that AngII reduces Aβ aggregation and membrane disruption in vitro. Biophysical assays and molecular modeling suggest AngII binds disordered Aβ forms, potentially modulating early amyloidogenic events and contributing to ...
Mohsen Habibnia, Eric Catalina‐Hernandez, Maialen Cabrerizo‐Idiazabal, Ramon Barnadas‐Rodríguez, Mario Lopez‐Martin, Alex Peralvarez‐Marin   +5 more
wiley   +1 more source

Quality-preserving multilevel mesh generation for building models

International Journal of Digital Earth
Three-dimensional (3D) high-fidelity building models are crucial for digital twin cities. Multi-scale modeling is crucial for accurately capturing the complexity of urban environments; however, existing methods often lack the flexibility required to ...
Hai Xu, Biao He, Chen Zhang, Haojia Lin, Xi Kuai, Renzhong Guo   +5 more
doaj   +1 more source

Effect of the Butyrate Prodrug Pivaloyloxymethyl Butyrate (AN9) on a Mouse Model for Spinal Muscular Atrophy. [PDF]

, 2016
Spinal muscular atrophy (SMA) is an early-onset motor neuron disease that leads to loss of muscle function. Butyrate (BA)-based compounds markedly improve the survival and motor phenotype of SMA mice.
Butchbach, Matthew E.R., Edwards, Jonathan D.   +1 more
core   +2 more sources

Evaluation of Children with SMA Type 1 Under Treatment with Nusinersen within the Expanded Access Program in Germany

Journal of Neuromuscular Diseases, 2018
Background: Spinal muscular atrophy (SMA) is a neuromuscular disorder characterized by muscle weakness and muscle atrophy. Nusinersen acts as a splicing modifier and has recently been approved for intrathecal treatment of SMA.
A. Pechmann, T. Langer, D. Schorling, S. Stein, Sibylle Vogt, U. Schara, H. Kölbel, O. Schwartz, A. Hahn, Kerstin Giese, J. Johannsen, J. Denecke, C. Weiss, M. Theophil, J. Kirschner   +14 more
semanticscholar   +1 more source

4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase in malaria parasites and enhances atovaquone efficacy

FEBS Letters, EarlyView.
Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer, Matheus Felipe Santos, Maurício Mazzine Filho, Gabriela Oliveira Castro, Agustín Hernández, Manoel Aparecido Peres, Alejandro Miguel Katzin, Marcell Crispim   +7 more
wiley   +1 more source

Numerical analysis of rainfall type landslide in Jichang town considering strain-softening

Shuiwen dizhi gongcheng dizhi
Rainfall infiltration not only changes the seepage field of the slope, but also reduces the soil strength, which is easy to induce landslide. The soil in the slip zone often shows strain softening during the landslide process.
Youjun JI, Jun XIONG, Guobin JIANG, Zegen WANG   +3 more
doaj   +1 more source

THE IMPLEMENTATION OF TEACHING SPEAKING AT SMA ISLAM\ud KEPANJEN [PDF]

, 2007
The objectives of this study were 1) to know the objective of teaching speaking at SMA Islam Kepanjen, 2) to know the topic covered in teaching speaking at SMA Islam Kepanjen, 3) to know the technique of teaching speaking at SMA Islam Kepanjen, 4) to ...
Rismawati, Aini
core  

Linked dimers of the AAA+ ATPase Msp1 reveal energetic demands and mechanistic plasticity for substrate extraction from lipid bilayers

FEBS Letters, EarlyView.
Cells must clear mislocalized or faulty proteins from membranes to survive. The AAA+ ATPase Msp1 performs this task, but dissecting how its six subunits work together is challenging. We engineered linked dimers with varied numbers of functional subunits to reveal how Msp1 subunits cooperate and use energy to extract proteins from the lipid bilayer ...
Deepika Gaur, Brian Acquaviva, Baylee A. Smith, Nathan Walker, Isabella Walter, Matthew L. Wohlever   +5 more
wiley   +1 more source

An evaluation of TLS-based glacier change assessment in the central Tibetan plateau

International Journal of Digital Earth
Fragmented surfaces and harsh environments have always been the main obstacles hindering observation works of glaciers in central Tibetan Plateau (TP). The advent of Terrestrial Laser Scanner (TLS) technology offers a potential revolution in this context.
Yuang Xue, Xiaofeng Hong, Xiaobo He, Shichang Kang, Shaoyong Wang, Yongjian Ding   +5 more
doaj   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source