Results 131 to 140 of about 357,035 (311)

A Circuit of Mechanically Regulated Transcription Factors Balances Regenerative and Fibrotic Memory of Mesenchymal Stromal Cells

Advanced Science, EarlyView.
Producing MSCs on rigid culture substrates induces a scar‐making phenotype, jeapordizing therapeutic success. ‘Tissue‐soft’ surfaces prevent MSC fibrogenesis and preserve regenerative traits. An epigenetic network, driven by HOXA11 and SALL1, maintains ‘soft memory’ by keeping chromatin open in relaxed MSCs, promoting anti‐fibrotic programs.
Fereshteh Sadat Younesi, Andrew E. Miller, Li Diao, Xinying Guo, Natalie Andonian, Elham Karimizadeh, Thomas H. Barker, Boris Hinz   +7 more
wiley   +1 more source

Development of Therapies for Spinal Muscular Atrophy Using Gene Therapy and Nanotechnology [PDF]

, 2013
Spinal muscular atrophy (SMA) is a genetic disease which is characterized by muscle weakness and atrophy. The disease arises from mutations in the survival motor neuron 1 (SMN1) gene causing degeneration of spinal cord motor neurons.
Little, Daniel
core  

FGL2‐HDAC11 Drives Immunothrombosis via NETs‐Mediated Endothelial Capillarization in MASLD Fibrosis

Advanced Science, EarlyView.
ABSTRACT Metabolic dysfunction–associated steatotic liver disease (MASLD) is frequently accompanied by hepatic fibrosis and systemic cardiovascular complications; however, the mechanistic interplay between coagulation abnormalities and disease progression remains poorly defined.
Xitang Li, Junjian Hu, Suping Hai, Peng Hu, Wenhui Wu, Qiang Gao, Binghui Yu, Feiyang Xu, Xizhe Zheng, Qianting Guan, Huiling Xiang, Dong Xi, Weiming Yan, Peng Wang, Bin‐hao Zhang, Qin Ning, Xiaojing Wang   +16 more
wiley   +1 more source

Analisis Gaya Bejalajar Siswa pada Mata Pelajaran Bahasa Inggris dalam Kurikulum Merdeka di Kelas X-B SMA Negeri 2 Bangli [PDF]

This study aims to describe the learning style of students in class X-B of SMA Negeri 2 Bangli in English subjects. Using qualitative and quantitative methods or mix methods with a case study approach, there are two instruments, such as questionnaires ...
Bagiada, Ketut; SMA Negeri 2 Bangli, Yosiani, Putu Dwila Yosiani; Institut Teknologi dan Pendidikan Markandeya Bali, Pradnyana, Putu Beny; Institut Teknologi dan Pendidikan Markandeya Bali, Rentiani, Ni Nyoman; Institut Teknologi dan Pendidikan Markandeya Bali   +3 more
core   +1 more source

MG53 Coordinates Macrophage Polarization and Neuroimmune Coupling to Promote Corneal Nerve Regeneration via the MPEG1–MVP–STAT6 Axis

Advanced Science, EarlyView.
Corneal nerve regeneration is critical to corneal wound healing processes. The current study reveals a novel role of MG53 in promoting corneal nerve regeneration after alkali induced injury. Mechanistically, MG53 enters macrophages via its receptor, MPEG1, promotes MVP K63 ubiquitination, and triggers STAT6 induced repair‐related genes expression ...
Peng Chen, Zhentao Zhang, Lilian Sakai, Yanping Xu, Luxi Zhang, Han Ye, William Sollenberger, Takahide Ikeda, Zhiyu Yan, Keerthika Sathish, Usman Alizai, Haitao Wen, Timothy M. Pawlik, Heather L. Chandler, Hua Zhu   +14 more
wiley   +1 more source

MANAJEMEN KEUANGAN SEKOLAH DI SMA NEGERI 2 SURAKARTA

, 2017
 ABSTRAK Sekolah adalah tempat melaksanakan aktifitas besar yang di dalamnya terdapat komponen-komponen yang saling berkaitan yaitu staf tata usaha, staf teknis pendidikan yang terdiri dari Kepala Sekolah dan Guru, Komite sekolah sebagai badan independen
-, Irmawati -; SMA Negeri 2 Surakarta
core  

Integrasi Nilai-Nilai Keteladanan Tokoh Pahlawan Nasional Brigjen K.H. Syam’un (1894-1949) Dalam Pembelajaran Sejarah Di SMA Negeri Kabupaten Serang

Tujuan dari penelitian ini adalah untuk mengetahui bagaimana Integrasi nilai-nilai keteladanan Tokoh pahlawan nasional Brigjen K.H. Syam’un (1894-1949) dalam pembelajaran sejarah di SMA Negeri Kabupaten Serang.
Erwinsyah, Erwinsyah; universitas Indraprasta PGRI, Permana, Rahayu; Universitas Indraprasta PGRI, Samsudin, Samsudin; Fakutas pascasarjana, Universitas Indraprasta PGRI SMAN 1 Ciruas   +2 more
core   +1 more source

Exploring the elastocaloric effect of Shape Memory Alloys for innovative biomedical devices: a review

Fracture and Structural Integrity
This paper discusses Shape Memory Alloys (SMA) elastocaloric effect (EC) and underscores its potential use in substituting conventional cooling systems, for future and innovative applications in the biomedical sector, where temperature has a significant
Girolamo Costanza, Ilaria Porroni, Maria Elisa Tata   +2 more
doaj   +1 more source

MEOX1 Coordinates Autocrine‐Paracrine Programs via SPHK1/S1P to Promote Lymph Node Metastasis in Ovarian Cancer

Advanced Science, EarlyView.
In ovarian cancer, MEOX1 activates the SPHK1/S1P pathway to promote both tumor progression and tumor–stroma crosstalk. MEOX1‐dependent signaling drives CAF activation, enhances VEGF‐C expression, and stimulates lymphangiogenesis, ultimately facilitating lymph node metastasis.
Jiajia Li, Xiuling Zhi, Qianhan Lin, Yating Sun, Yihua Sun, Zulimire Abudousalamu, Mengyang Xue, Chang Zheng, Xiaotian Li, Liangqing Yao, Mo Chen   +10 more
wiley   +1 more source

Multi‐Omics Profiling Reveals Immunomodulatory and Pro‐Regenerative Effects of a Graphene Oxide–Collagen Scaffold in Massive Rotator Cuff Tears

Advanced Science, EarlyView.
A graphene oxide/collagen scaffold is developed for chronic massive rotator cuff tear repair. The scaffold improves compressive stability, supports reparative mesenchymal differentiation, and modulates the immune microenvironment. In chronic MRCT models, it reduces muscle degeneration, enhances tendon–bone regeneration, and improves functional recovery,
Renwen Wan, Yechuan Deng, Zixin Hu, Yanwei He, Xinting Feng, Jun Ma, Yisheng Chen, Zhijie Zhao, Jie Mei, Zhiheng Lin, Wei Luo, Zhengyuan Fang, Zhufeng Hu, Kunlun Feng, Xinrong Li, Dan Wu, Bowen Han, James Hoi po Hui, Xuanyong Liu, Chen Chen, Gang Chen, Shiyi Chen, Nirong Bao, Jiajun Qiu, Zhiwen Luo   +24 more
wiley   +1 more source