Results 301 to 310 of about 1,350,741 (373)

SETDB2 Mitigates Podocyte Dysfunction in Diabetic Kidney Disease Through Epigenetic Silencing of SMAD3

open access: yesAdvanced Science, EarlyView.
SETDB2 epigenetically represses Smad3 transcription by increasing H3K9me3 enrichment at its promoter, thereby mitigating podocyte dysfunction in DKD. The transcription factor TCF21 binds directly to the Setdb2 promoter and enhances its expression in podocytes. Abstract Podocyte dysfunction represents both an early pathological hallmark and a key driver
Lanfang Li   +14 more
wiley   +1 more source

Precise Construction of an Antimicrobial Peptide Targeting Bacterial Cell Membranes Derived From Natural Peptides

open access: yesAdvanced Science, EarlyView.
An AMP (P 3‐3R‐8I) based on natural peptides, which can target bacterial cell membranes, was precisely constructed via amino acid mutation. P 3‐3R‐8I exhibits antibacterial capability which could be attributed to the ability of P 3‐3R‐8I to quickly penetrate bacterial cell membranes and then to bind to bacterial DNA.
Jiaqi Huang   +11 more
wiley   +1 more source

Traumatic superior mesenteric artery pseudoaneurysm complicated by high-output arteriovenous fistula. [PDF]

open access: yesJ Vasc Surg Cases Innov Tech
Ahmedfiqi Y   +5 more
europepmc   +1 more source

Manipulation of Emergent Collective Excitations via Composition Control in Mixed MPX3 Correlated 2D Antiferromagnets

open access: yesAdvanced Science, EarlyView.
Transition metal and chalcogen substituents are introduced into 2D antiferromagnet, NiPS3, and comprehensive photoluminescence and Raman spectroscopy studies are conducted to investigate how spin orbit entangled exciton and two magnon scattering evolve as functions of substituent concentration.
Cong Tai Trinh   +12 more
wiley   +1 more source

Clinical relevance of zebrafish for gene variants testing. Proof-of-principle with SMN1/SMA. [PDF]

open access: yesEMBO Mol Med
Stringer BW   +7 more
europepmc   +1 more source

One‐Step Coaxial 3D Printing of Pre‐Vascularized Skin Organoid Models with ADSC Microspheres for Enhanced Wound Healing

open access: yesAdvanced Science, EarlyView.
A multifunctional vascular bed platform is created using coaxial 3D printing, allowing the one‐step integration of organoid microspheres with perfusable vascular structures. This strategy enables rapid and functional vascularization of organoids to support tissue repair and vascularization, providing a scalable and translationally promising approach ...
Kunrui Wang   +10 more
wiley   +1 more source

Photothermal–Immunomodulatory Hydrogel Reinforced by Ti3C2/ZnAl‐LDH Nanoplatform for Eradicating MRSA and Promoting Diabetic Wound Healing

open access: yesAdvanced Science, EarlyView.
A NETs‐inspired Ti3C2/LDH hydrogel integrates trapping, ROS boosting, and M2‐immunomodulation for MRSA‐infected wound repair. ABSTRACT MRSA infections give rise to chronic cutaneous and advance into profound tissue invasions, including osteomyelitis and sepsis—conditions for which existing clinical interventions offer only limited efficacy. The utility
Qiang Shi   +6 more
wiley   +1 more source

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