Results 81 to 90 of about 1,350,741 (373)

Effect of the Butyrate Prodrug Pivaloyloxymethyl Butyrate (AN9) on a Mouse Model for Spinal Muscular Atrophy. [PDF]

, 2016
Spinal muscular atrophy (SMA) is an early-onset motor neuron disease that leads to loss of muscle function. Butyrate (BA)-based compounds markedly improve the survival and motor phenotype of SMA mice.
Butchbach, Matthew E.R., Edwards, Jonathan D.   +1 more
core   +2 more sources

Multiband Switchable Microwave Absorbing Metamaterials Based on Reconfigurable Kirigami–Origami

Advanced Functional Materials, EarlyView.
A reconfigurable metamaterial featuring tunable microwave‐absorbing and load‐bearing performance is proposed. Stretchable kirigami and bistable origami configurations are integrated as actuating components, and the synergistic deformation mechanisms are systematically analyzed.
Weimin Ding, Zhong Zhang, Zeang Zhao, Shengyu Duan, Panding Wang, Xiaogang Guo, Hongshuai Lei, Daining Fang   +7 more
wiley   +1 more source

Neurochemical markers in CSF of adolescent and adult SMA patients undergoing nusinersen treatment

Therapeutic Advances in Neurological Disorders, 2019
Background: There is limited information on neurochemical markers being used to support and monitor the affection of motoneurons in patients with spinal muscular atrophy (SMA).
C. Wurster, R. Günther, P. Steinacker, J. Dreyhaupt, K. Wollinsky, Z. Uzelac, S. Witzel, T. Kocak, B. Winter, J. Koch, P. Lingor, S. Petri, A. Ludolph, A. Hermann, M. Otto   +14 more
semanticscholar   +1 more source

A Vascular Microphysiological Model of Lung Fibrosis Reveals That Myofibroblasts and IPF Patient‐Derived Fibroblasts Impair Angiogenesis and Vasculogenesis

Advanced Functional Materials, EarlyView.
A microphysiological lung fibrosis model recapitulates myofibroblast–vascular interactions. Induced myofibroblasts and patient‐derived IPF fibroblasts impair angiogenesis and increase vascular permeability via TGF‐β1–driven signaling. Pharmacological interventions with SB 431542 and VEGF supplementation restore vascular morphology and barrier function.
Elena Cambria, Adriana Blazeski, Eunkyung Clare Ko, Tran Thai, Shania Dantes, David A. Barbie, Sarah E. Shelton, Roger D. Kamm   +7 more
wiley   +1 more source

A Laryngoscope with Shape Memory Actuation

Current Directions in Biomedical Engineering
Endotracheal intubation is a medical procedure to secure a patient’s airways, which can be challenging in emergency situations due to an individual’s anatomy. Intubation blades can benefit from an adjustable design with shape memory alloys.
Fischer Nikola, Ho Patty, Marzi Christian, Schuler Patrick, Mathis-Ullrich Franziska   +4 more
doaj   +1 more source

Modeling and sensorless tension control of SMA actuator using GRU

Nihon Kikai Gakkai ronbunshu, 2020
This paper proposes a method for sensorless tension control of shape memory alloy(SMA) actuators. Sensorless control has advantages in cost and size. Gated recurrent unit(GRU) was adopted to model complex characteristics of the SMA actuators.
Soki ITO, Hiroyuki HARADA
doaj   +1 more source

Explicit finite element implementation of a shape memory alloy constitutive model and associated analyses [PDF]

, 2017
Shape memory alloys (SMA) represent an important class of smart metallic materials employed in various innovative applications thanks to their unique thermomechanical behavior.
Auricchio, F., Boatti, E., Ferraro, M., Hartl, D.J., Mercuri, V., Scalet, G.   +5 more
core  

Novel Omega-3 Fatty Acid Epoxygenase Metabolite Reduces Kidney Fibrosis. [PDF]

, 2016
Cytochrome P450 (CYP) monooxygenases epoxidize the omega-3 polyunsaturated fatty acid (PUFA) docosahexaenoic acid into novel epoxydocosapentaenoic acids (EDPs) that have multiple biological actions.
Hammock, Bruce D, Hye Khan, Md Abdul, Imig, John D, Lee, Kin Sing Stephen, Levick, Scott P, Sharma, Amit   +5 more
core   +3 more sources

A multi-source approach to determine SMA incidence and research ready population

Journal of Neurology, 2017
In spinal muscular atrophy (SMA), degeneration of motor neurons causes progressive muscular weakness, which is caused by homozygous deletion of the SMN1 gene.
I. Verhaart, A. Robertson, R. Leary, G. McMacken, Kirsten König, J. Kirschner, Cynthia C. Jones, Suzanne F. Cook, Hanns Lochmüller   +8 more
semanticscholar   +1 more source

Electroactive Liquid Crystal Elastomers as Soft Actuators

Advanced Functional Materials, EarlyView.
Electroactive liquid crystal elastomers (eLCEs) can be actuated via electromechanical, electrochemical, or electrothermal effects. a) Electromechanical effects include Maxwell stress, electrostriction, and the electroclinic effect. b) Electrochemical effects arise from electrode redox reactions.
Yakui Deng, Min‐Hui Li
wiley   +1 more source