Lock, relax, load, and shoot: a molecular perspective on Nedd4 regulation
Structural basis of inactive and active states of the Nedd4 HECT E3 ligase subfamily, following a ‘lock, relax, load, and shoot’ mechanism. In the locked, autoinhibited state, intramolecular domain interactions restrain the HECT domain. Relaxation releases these restraints, allowing loading of ubiquitin onto the catalytic cysteine, followed by the ...
Masa Janosev +2 more
wiley +1 more source
ABSTRACT We examine how mergers and acquisitions (M&As) enable firms to adapt to climate policy shocks. Exploiting the adoption of the Nitrogen Oxides (NOx) Budget Trading Program (NBP) across US states as an exogenous shock, we find that firms with NOx‐emitting plants subject to the NBP are more likely to engage in M&As, particularly through vertical ...
Samer Adra +3 more
wiley +1 more source
Dating Apps and the Right to an Explanation
ABSTRACT This article argues that in countries where dating apps have become the primary means of meeting romantic partners and promise to help users find love, individuals should be entitled to access certain information about how their algorithms function. Specifically, we advocate for a legal right to an explanation that addresses the following, not
Bouke de Vries +1 more
wiley +1 more source
Occurrence of Ticks and Tick-Borne Pathogens During Warm Winter-A Snapshot from Central Europe. [PDF]
Buczek W +6 more
europepmc +1 more source
Estimating National and Foreign Trade Elasticities Using Generalized Transport Costs
ABSTRACT We introduce the definition of two distinct trade elasticities corresponding to imports from regions located in the same country (national elasticities) and foreign regions located in other countries (foreign elasticities). We resort to a three‐tier nested CES utility structure to derive the corresponding demand gravity equations.
José L. Zofío +3 more
wiley +1 more source
Differences in phenological term changes in field crops and wild plants - do they have the same response to climate change in Central Europe? [PDF]
Bartošová L +9 more
europepmc +1 more source
Severity of Betel Quid Use Disorders (BUD) Among Adult Indian Betel Quid Chewers
ABSTRACT Objective Oral cancer is a major public health problem in India, with the highest number of cases and deaths in the world, and Betel Quid (BQ) chewing is responsible for almost 50% of cases. BQ Use Disorder (BUD) prevalence and severity have never been investigated among Indian BQ chewers.
Stefano Petti +9 more
wiley +1 more source
Evaluating the efficacy of Chenopodium murale plant extract in inhibiting Streptococcus mutans and reducing dental caries risk. [PDF]
Kanwal S +13 more
europepmc +1 more source
Syntaxonomic Conspectus of the Vegetation of Catalonia and Andorra. I: Hygropilous Herbaceous Communities [PDF]
Carreras i Raurell, Jordi +3 more
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