Results 11 to 20 of about 6,718,160 (281)

Tadalafil may improve cerebral perfusion in small-vessel occlusion stroke-a pilot study. [PDF]

Brain Commun, 2020
Abstract New treatments for cerebral small-vessel disease are needed to reduce the risk of small-vessel occlusion stroke and vascular cognitive impairment. We investigated an approach targeted to the signalling molecule cyclic guanosine monophosphate, using the phosphodiesterase 5 inhibitor tadalafil, to explore if it improves ...
Ölmestig J, Marlet IR, Hansen RH, Rehman S, Krawcyk RS, Rostrup E, Lambertsen KL, Kruuse C.   +7 more
europepmc   +7 more sources

Mechanical thrombectomy for large vessel occlusion with large ischaemic core 

Advances in Clinical Neuroscience & Rehabilitation
Endovascular therapy in acute ischemic stroke with large vessel occlusion changed the landscape of stroke treatment. Early randomised trials largely focused on patients with small to moderate ischemic core defined as ASPECTS 6 or greater.
Thanh N. Nguyen, Anurag Sahoo, Mohamad Abdalkader, Xiaochuan Huo, Zhongrong Miao, Marc Fisher   +5 more
doaj   +2 more sources

Ischemic Preconditioning Negatively Affects Thrombogenic Clotting Profile in Cerebral Small Vessel Occlusion Stroke Patients. [PDF]

J Clin Med Res
The study evaluated the effect of an acute and a 2-week daily repetitive ischemic preconditioning (IPC) on conduit artery vascular function and thrombogenic clotting profile, in patients with a recent ischemic stroke.Fourteen patients, aged 71 ± 8 years, with a cerebral small vessel occlusion stroke were included in a randomized, controlled, open-label
Norregaard LB, Rytter N, Christoffersen LC, Gliemann L, Hansen CS, Lawrence M, Evans PA, Kruuse C, Hellsten Y.   +8 more
europepmc   +8 more sources

Intravenous thrombolysis with tissue-plasminogen activator in small vessel occlusion

Journal of Clinical Neuroscience, 2019
Intravenous tissue-plasminogen activator (IV-TPA) treatment in acute ischemic stroke (AIS) patients due to small vessel occlusion (SVO) has been debated because of its small expected benefit and symptomatic intracranial hemorrhage (SICH) risk. Furthermore, data on subgroups of SVO patients are limited.
Young Min, Paek, Ji Sung, Lee, Hong-Kyun, Park, Yong-Jin, Cho, Hee-Joon, Bae, Beom Joon, Kim, Jong-Moo, Park, Soo Joo, Lee, Jae-Kwan, Cha, Tai Hwan, Park, Kyung Bok, Lee, Jun, Lee, Byung-Chul, Lee, Joon-Tae, Kim, Dong-Eog, Kim, Dong-Ick, Shin, Wook-Joo, Kim, Sung-Il, Sohn, Jay Chol, Choi, Keun-Sik, Hong   +19 more
openaire   +3 more sources

The functional impact on donor vessel following transcatheter closure of coronary artery fistulas—a retrospective study using QFR analysis [PDF]

Frontiers in Cardiovascular Medicine
BackgroundThe impact of transcatheter closure of coronary artery fistula (CAF) and residual shunt after occlusion on improving blood flow in the donor vessel remains uncertain.ObjectivesTo evaluate the functional impact on the donor vessel following CAFs
Zhenchi Sang, Qingqi Ji, Huan Tong, Linghong Shen, Xiaolong Wang, Ben He   +5 more
doaj   +2 more sources

Immediate Small Side Branch Occlusion after Percutaneous Coronary Intervention [PDF]

Journal of Tehran University Heart Center, 2007
Background: Small side branches, albeit less important than their larger counterparts, have not yet received due attention in the literature. Nor has there ever been a comparison between drug-eluting stents and bare metal stents apropos side branch ...
Mohammad Ali Ostovan, Reza Mollazadeh
doaj   +3 more sources

Association of CYP26C1 Promoter Hypomethylation with Small Vessel Occlusion in Korean Subjects. [PDF]

Genes (Basel), 2021
The risk factors for stroke, a fatal disease, include type two diabetes, hypertension, and genetic influences. Small vessel occlusion (SVO) can be affected by epigenetic alterations, but an association between SVO and the methylation of cytochrome P450 family 26 subfamily C member 1 (CYP26C1) has not been identified.
Lee EJ, Kim MS, Yim NH, Cha MH.
europepmc   +4 more sources

Serum Homocysteine Is Associated With HDL Only in Stroke Patients With Small Vessel Occlusion. [PDF]

Front Neurol, 2020
Background: Although controversial, homocysteine (Hcy) and lipid parameters have been associated with particular stroke subtypes. However, there are limited studies concerning the relationship between Hcy and lipid levels in acute ischemic stroke (AIS). We evaluated the impact of Hcy levels on lipid profiles in terms of specific stroke subtypes.Methods:
Kim Y, Lee JH, Lee SH, Kim YJ, Kim C, Jang MU, Jung S, Lim JS, Oh MS, Yu KH, Lee BC.   +10 more
europepmc   +5 more sources

Deep medullary vein damage correlates with small vessel disease in small vessel occlusion acute ischemic stroke. [PDF]

Eur Radiol
Abstract Objectives We aim to investigate whether cerebral small vessel disease (cSVD) imaging markers correlate with deep medullary vein (DMV) damage in small vessel occlusion acute ischemic stroke (SVO-AIS) patients. Methods The DMV was divided into six segments according ...
Wang X, Lyu J, Duan Q, Li C, Huang J, Meng Z, Wu X, Chen W, Wang G, Niu Q, Li X, Bian Y, Han D, Guo W, Yang S, Bian X, Lan Y, Wang L, Zhang T, Duan C, Lou X, MR-STARS Investigators.   +21 more
europepmc   +3 more sources

Review: Preclinical Models of Large‐Vessel Occlusion Stroke

Stroke: Vascular and Interventional Neurology
Preclinical models of large‐vessel occlusion (LVO) stroke play an important role in testing novel thrombolytic and neuroprotective agents, as well as assessing endovascular devices for endovascular thrombectomy.
Alexander Keister, Arianna Carfora, Mayur S. Patel, Amanda S. Zakeri, Lillian Mannix, Debra G. Wheeler, Paco S. Herson, Shahid M. Nimjee   +7 more
doaj   +2 more sources