Results 111 to 120 of about 11,122,863 (290)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

open access: yesFEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas   +6 more
wiley   +1 more source

Small Farms Quarterly - Spring 2016

open access: yes, 2016
Small Farm Quarterly is for farmers and farm families — including spouses and children - who value the quality of life that smaller farms provide. OUR GOALS ARE TO: Celebrate the Northeast region’s smaller farms; Inspire and inform farm families and ...
Cornell Small Farms Program
core  

The culture of public fathers in the small city: Where does the culture of involved fathering reside in the public spaces of the small city? [PDF]

open access: yes, 2011
Father Involvement research often focuses on issues relating to the impacts of paternal engagement on child development and the broader benefits of Father Involvement for fathers and their families.

core   +2 more sources

AI-Assisted Double-Headed Capsule Endoscopy: Multicentre Prospective Diagnostic Accuracy Study Across Small Bowel Indications

open access: yesDiagnostics
Background/Aims: Double-headed capsule endoscopy enhances visualization and diagnostic yield in small bowel evaluation but increases reading time. This study aimed to assess the diagnostic performance of AI-assisted double-headed capsule endoscopy ...
Kamran Mushtaq   +9 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Small Farms Quarterly - Fall 2015

open access: yes, 2015
Small Farm Quarterly is for farmers and farm families — including spouses and children - who value the quality of life that smaller farms provide. OUR GOALS ARE TO: Celebrate the Northeast region’s smaller farms; Inspire and inform farm families and ...
Cornell Small Farms Program
core  

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

open access: yesFEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

Small Farms Quarterly - Summer 2016

open access: yes, 2016
Small Farm Quarterly is for farmers and farm families — including spouses and children - who value the quality of life that smaller farms provide. OUR GOALS ARE TO: Celebrate the Northeast region’s smaller farms; Inspire and inform farm families and ...
Cornell Small Farms Program
core  

Desmoplastic small round cell tumor: A case report in a young Filipino woman and review of literature

open access: yesPhilippine Journal of Obstetrics and Gynecology
Desmoplastic small round cell tumor (DSRCT) is a rare and highly aggressive soft-tissue sarcoma that commonly presents late in the disease due to its nonspecific symptoms. Due to its rarity, there is still no standardized treatment regimen.
Julienne Katrina Bulaon Beltran   +1 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

open access: yesFEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson   +6 more
wiley   +1 more source

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