Results 111 to 120 of about 11,701 (259)

“Membrane‐Guided” Repair Strategy: Precision Delivery of GGT1 Degrader for Targeted Repair and Regeneration of Spinal Cord Neurons

Advanced Science, EarlyView.
This study confirms that GGT1 is a key driver of neuronal ferroptosis following spinal cord injury. We developed NSCm@EA, a biomimetic delivery system coated with neural stem cell membranes, for precise delivery of enocyanin to injured neurons. By combining targeted delivery with ubiquitination degradation mechanisms, this system promotes MGRN1 ...
Tao Yang, Lei Ye, Peigen Xie, Tao Song, Jian Chen, Heng Zhao, Zhengshan Liu, Xi Chen, Jianing Ding, Xintian Ding, Ao Shao, Miaomiao Wu, Fengdong Zhao, Siyue Tao, Tao You   +14 more
wiley   +1 more source

Field‐Free Spin‐Splitting‐Torque Driven Stochastic Neuron Mimicking the Neuromorphic Imagination for High‐Performance Recognition

Advanced Science, EarlyView.
The human brain's imagination, which enables autonomous driving hazard avoidance by completing missing visual information, relies on Gaussian‐stochastic neuron. We report the altermagnetic RuO2 spintronic neurons integrating field‐free switching and intrinsic Gaussian stochasticity, building an all‐spin ANN for high‐quality image repairing and high ...
Junwei Zeng, Baoshan Cui, Xi Guo, Jiahao Liu, Xiaoyu Feng, Liang Fang, Li Xi, Xiaolong Fan, Xiaoxi Liu, Yang Guo   +9 more
wiley   +1 more source

A Plug‐and‐Play Platform for Customizing Multivalent Degraders and Degrader‐Drug Conjugates

Advanced Science, EarlyView.
Membrane proteins remain challenging targets for conventional TPD approaches. Here, the authors develop UPTAB, a modular platform leveraging ultrahigh‐affinity orthogonal Im/CL protein pairs for lysosomal degradation of membrane proteins. Mono‐targeted (Type‐I), dual‐targeted (Type‐II), and tri‐targeted (Type‐III) UPTABs enable simultaneous degradation
Mengqing Zhao, Yan Deng, Jianjian Han, Yong Xie, Kai Bao, Lixin Ma, Lilong Liu, Wuxiang Mao   +7 more
wiley   +1 more source

Toward Long‐Term Reliable Human‐Machine Interaction: A Flexible, Breathable, and Self‐Powered Pressure Sensor System With Firefighting Validation

Advanced Science, EarlyView.
This work develops a breathable potentiometric self‐powered pressure sensor with good wearability, using a non‐woven fabric substrate and hydrogel electrolyte. The sensor is integrated into a five‐channel smart glove to acquire reliable hand motion signals, which are processed by a CNN for identity verification and smart vehicle control in human ...
Qilong Zhang, Zhao Yao, Jiaxu Liu, Yuxuan Hou, Zhongtao Zhang, Jingwei Xue, Leonid Chernogor, Nam Young Kim, Eun Seong Kim, Yuanyue Li, Yang Li   +10 more
wiley   +1 more source

Self‐Adaptive Non‐Flammable Wallpaper With Layered Bead‐Network Structure for Light Path Modulation Enabling on‐Demand Building Thermal Management

Advanced Science, EarlyView.
A layered bead‐network wallpaper is designed to modulate the light propagation path, overcoming the color residue limitations of thermochromic components for efficient automatic switching between radiative cooling and solar heating modes. The layered bead‐network wallpaper provides passive, all‐season thermal regulation while offering self‐cleaning and
Jianyu Wu, Linmin Xia, Jiankun Wu, Yuying Yang, Wuhong Zhong, Jianguo Li, Yan Yu, Rilong Yang   +7 more
wiley   +1 more source

Hierarchical Twin Networks Enable Exceptional Strength and Fracture Toughness in Titanium

Advanced Science, EarlyView.
A commercial‐purity titanium with hierarchical ultrafine twin structures delivers an exceptional combination of fracture toughness (KJIc) of 187 MPa·m1/2 and specific yield strength of 140 MPa·cm3·g−1, in which pre‐engineered high‐density twin boundaries stimulate massive and dislocations to blunt crack tip.
Xiao‐Wei Zou, Ting Zhu, En Ma, Wei‐Zhong Han   +3 more
wiley   +1 more source

Modern Development of Small and Medium-Sized Cities: Trends and Drivers

Economic and Social Changes: Facts, Trends, Forecast / Экономические и социальные перемены: факты, тенденции, прогноз, 2022
Svetlana Rastvortseva, Inna Manaeva
openaire   +1 more source

Pressure‐Driven Phase Transition Unlocking Unique Eu2+ Luminescence in Li2SrSiO4 for Optical Sensing and White‐LEDs

Advanced Science, EarlyView.
This study demonstrates, for the first time, the use of a large‐format high‐pressure press to modify synthesized Li2SrSiO4:Eu2+,Cs+ phosphors after its preparation. The pressure treatment results in the formation of new materials with distinctive optical properties, opening pathways for the development of advanced LED devices and high‐performance ...
Przemysław Woźny, Peng Du, Teng Zheng, Junpeng Xue, Liang Peng, Shuailing Ma, Szymon Sobczak, Victor Lavín, Tian Cui, Marcin Runowski   +9 more
wiley   +1 more source

A Disaggregation Strategy for Nanopesticide Fabrication: Investigating the Impact of Nanosizing on Pesticide Biointeractions

Advanced Science, EarlyView.
To explore the impact of nanosizing on pesticide biointeractions, a 7‐nm (average) emamectin benzoate nanopesticide without nanocarriers or surfactants is fabricated via HOAc‐mediated disaggregation. Nanosizing enhances bioactivity against Megalurothrips usitatus and Meloidogyne enterolobii and improves plant penetration.
Jiaqi Wei, Jianxin Feng, Huiting Zhu, Kunzhong Lin, Chenhan Liu, Lin Li, Zhuoyan Xiao, Daihao Huang, Rong Liu, Huipeng Pan, Lingda Zeng, Hanhong Xu   +11 more
wiley   +1 more source

Small and medium-sized towns: out of the dark agglomeration shadows and into the bright city lights?

, 2022
Evert Meijers, Martijn Burger
openaire   +2 more sources