Results 41 to 50 of about 235,098 (310)

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Market entry decisions of US small and medium‐sized software firms [PDF]

Management Decision, 2008
PurposeThe purpose of this paper is to investigate market entry decisions of the US software SMEs by analyzing the impact of the most obvious factors (cultural distance, geographical distance, country risk, and three market size variables) in traditional internationalization theories to target country selection.
Ojala, Arto, Tyrväinen, Pasi
openaire   +2 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

High-performance work systems and workplace performance in small, medium-sized and large firms [PDF]

, 2014
This paper draws on the Organisational Growth and Development (OGD) lifecycle model to extend understanding of congruence or ‘best fit’ theory within strategic human resource management (SHRM) debates on the relationship between high performance work ...
Arbuckle, Baird, Becker, Bentler, Cardon, Carlson, Chadwick, Combs, Datta, Deshpande, Dundon, European Commission, Faems, Forth, Forth, Greiner, Guest, Heneman, Kersley, Kok, Kotey, Messersmith, Muthén, OECD, Patel, Podsakoff, Razouk, Rubin, Rutherford, Satorra, Satorra, Scase, Sels, Serrasqueiro, Sheehan, Snell, Storey, Teo, Tocher, Wall, Way, Wood, Wood   +42 more
core   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Technological collaboration : bridging the innovation gap between small and large firms [PDF]

, 2010
This paper analyzes how technological collaboration acts as an input to the innovation process and allows small and medium-sized entetprises to bridge the innovation gap with their bigger counterparts.
Acs, Ahern, Audretsch, Barnir, Baum, Bayona, Becheikh, Beise, Beneito, Bierly, Blomqvist, Bougrain, Bozeman, Cassiman, Cohen, Cohen, Cohen, Cuervo-Cazurra, Dickson, Drejer, Duysters, Edwards, European Commission, Feldman, Forrest, Freel, Freel, Fritsch, Galende, Geisler, Gibbons, Greene, Hagedoorn, Hagedoorn, Hagedoorn, Heckman, Hewitt-Dundas, Hoffman, Hsiao, Huergo, Izushi, Jones, Kumar, Lambrecht, Lewin, Lluís Santamaría, Martínez-Ros, María Jesús Nieto, Miles, Miotti, Mytelka, Narula, Neter, Nieto, Nooteboom, Okamuro, Ornaghi, Piergiovanni, Piga, Pisano, Powell, Rogers, Rolfo, Rothwell, Rothwell, Schumpeter, Smallbone, Smith, Stock, Surroca, Tether, Tsai, Van Dijk, Verhees, Veugelers, Von Hippel, Vossen, Vuola, Walsh, Whitley, Williamson, Wolff, Zahra   +82 more
core   +3 more sources

EDNRB‐dependent endothelin signaling reduces proliferation and promotes proneural‐to‐mesenchymal transition in gliomas

Molecular Oncology, EarlyView.
Glioma cells mainly express the endothelin receptor EDNRB, while EDNRA is restricted to a perivascular tumor subpopulation. Endothelin signaling reduces glioma cell proliferation while promoting migration and a proneural‐to‐mesenchymal transition associated with poor prognosis. This pathway activates Ca2+, K+, ERK, and STAT3 signalings and is regulated
Donovan Pineau, Leonor Garcia, Hugo Arnold, Antonija Hanžek, Maialen Arrieta, Laurent R Gauthier, Christine Granotier‐Beckers, François D Boussin, Amaury Herbet, Marie Hautière, Valentin Asei‐Ceschino, Clémentin Jacques, Laura Brard, Thomas Harnois, Valérie Coronas, Bruno Constantin, Aurélien Chatelier, Jean Chemin, Serge Urbach, Martial Seveno, Szimonetta Hideg, Chantal Ripoll, Kasandra Aguilar‐Cázarez, Min Zheng, Guo‐Hao Huang, Sheng‐Qing Lv, Lei Zhang, Philippe Rondard, Laurent Prezeau, Jean‐Philippe Pin, Hugues Duffau, Luc Bauchet, Valérie Rigau, Franck Denat, Charles Truillet, Didier Boquet, Jean‐Philippe Hugnot   +36 more
wiley   +1 more source

Employee involvement and participation in SMEs: a synthesis of extant research

Journal of Evolutionary Studies in Business, 2018
It is widely acknowledged that small and medium-sized enterprises (SMEs) cannot afford underutilize their workforce and owner/managers encourage ways to involve employees.
Sylvia Rohlfer
doaj   +1 more source

Externalities of the sanction pressure policy and its consequences for the Russian small and medium business development

Russian Journal of Economics and Law, 2023
Objective: to analyze the impact of the externalities of the sanctions pressure policy on small and medium-sized enterprises and to develop specific proposals that allow them to adapt to the conditions of uncertainty.Methods: general scientific methods ...
E. A. Koroleva
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source