Results 101 to 110 of about 13,918,392 (293)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Small area estimation on poverty indicators [PDF]

We propose to estimate non-linear small area population quantities by using Empirical Best (EB) estimators based on a nested error model. EB estimators are obtained by Monte Carlo approximation.
J.N.K. Rao, Isabel Molina
core  

Laporan Februari 2019 Perpustakaan Universitas Medan Area

, 2019
52 HalamanPuji syukur kepada Allah SWT, karena atas Karunia dan Rahmat-Nya laporan bulanan Perpustakaan Universitas Medan Area Bulan Februari 2019 dapat tersusun dengan baik.
Perpustakaan, Universitas Medan Area
core   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

Public health air pollution impacts of pathway options to meet the 2050 UK Climate Change Act target: a modelling study

Public Health Research, 2018
Background: The UK’s Climate Change Act 2008 (CCA; Great Britain. Climate Change Act 2008. Chapter 27. London: The Stationery Office; 2008) requires a reduction of 80% in carbon dioxide-equivalent emissions by 2050 on a 1990 base. This project quantified
Martin L Williams, Sean Beevers, Nutthida Kitwiroon, David Dajnak, Heather Walton, Melissa C Lott, Steve Pye, Daniela Fecht, Mireille B Toledano, Mike Holland   +9 more
doaj   +1 more source

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Laporan November 2018 Perpustakaan Universitas Medan Area

, 2018
67 HalamanPuji syukur kepada Allah SWT, karena atas Karunia dan Rahmat-Nya laporan bulanan Perpustakaan Universitas Medan Area Bulan November 2018 dapat tersusun dengan baik.
Perpustakaan, Universitas Medan Area
core   +1 more source

Establishment of Southern Highbush Blueberry Cultivars and Suppression of Phytophthora Root Rot Using Cover Crop and Soil Amendment Treatments

PhytoFrontiers
Phytophthora root rot is a major disease of blueberry that relies on cultural practices, including soil amendments, for disease management. We evaluated the effect of three cover crops on the establishment and growth of southern highbush blueberry (SHB ...
Barbara J. Smith, Eric T. Stafne, Quentin D. Read   +2 more
doaj   +1 more source

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

Molecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura, Tadahiro Kuribayashi, Johannes Brägelmann, Sachi Okawa, Masataka Taoka, Shunta Mori, Tomoka Nishimura, Takaaki Tanaka, Go Makimoto, Kiichiro Ninomiya, Kammei Rai, Eiki Ichihara, Ryohei Katayama, Katsuyuki Hotta, Masahiro Tabata, Yosuke Togashi, Yoshinobu Maeda, Martin L. Sos, Katsuyuki Kiura, Kadoaki Ohashi   +19 more
wiley   +1 more source

Single-cell transcriptome analysis reveals elongation and ossification characteristics of antlers

Frontiers in Veterinary Science
IntroductionAntlers are specialized bony appendages in mammals that exhibit the remarkable ability to periodically regenerate from the pedicles and then rapidly elongate to form bone.
Ruobing Han, Ruobing Han, Qianghui Wang, Heping Li   +3 more
doaj   +1 more source