Results 51 to 60 of about 1,760,812 (299)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Multi-outcome longitudinal small area estimation – a case study

open access: yesStatistical Theory and Related Fields, 2019
A recent paper [Thibaudeau, Slud, and Gottschalck (2017). Modeling log-linear conditional probabilities for estimation in surveys. The Annals of Applied Statistics, 11, 680–697] proposed a ‘hybrid’ method of survey estimation combining coarsely cross ...
Eric Slud, Yves Thibaudeau
doaj   +1 more source

Small Area Estimation Using a Spatio-Temporal Linear Mixed Model

open access: yesRevstat Statistical Journal, 2012
In this paper it is proposed a spatio-temporal area level linear mixed model involving spatially correlated and temporally autocorrelated random effects.
Luís N. Pereira , Pedro S. Coelho
doaj   +1 more source

Small Area Estimation of Latent Economic Well-being

open access: yesSociological Methods & Research, 2019
Small area estimation (SAE) plays a crucial role in the social sciences due to the growing need for reliable and accurate estimates for small domains. In the study of well-being, for example, policy makers need detailed information about the geographical
A. Moretti, N. Shlomo, J. Sakshaug
semanticscholar   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

A Spatial Unit Level Model for Small Area Estimation

open access: yesRevstat Statistical Journal, 2011
This paper approaches the problem of small area estimation in the framework of spatially correlated data. We propose a class of estimators allowing the integration of sample information of a spatial nature.
Pedro S. Coelho , Luís N. Pereira
doaj   +1 more source

A novel application of small area estimation in loblolly pine forest inventory

open access: yesForestry: An International Journal of Forest Research, 2019
Loblolly pine (Pinus taeda L.) is one of the most widely planted tree species globally. As the reliability of estimating forest characteristics such as volume, biomass and carbon becomes more important, the necessary resources available for assessment ...
P. Green   +3 more
semanticscholar   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

open access: yesFEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy   +4 more
wiley   +1 more source

Diversity and complexity in neural organoids

open access: yesFEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Small area estimation of poverty indicators [PDF]

open access: yesCanadian Journal of Statistics, 2010
AbstractThe authors propose to estimate nonlinear small area population parameters by using the empirical Bayes (best) method, based on a nested error model. They focus on poverty indicators as particular nonlinear parameters of interest, but the proposed methodology is applicable to general nonlinear parameters.
Rao, J.N.K., Molina, Isabel
openaire   +4 more sources

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