Results 211 to 220 of about 490,234 (264)

DDX3x Regulates NINJ1 Transcription via Histone Lactylation in Sepsis Associated‐Acute Kidney Injury

Advanced Science, EarlyView.
This study identifies a potential therapeutic approach for sepsis‐associated acute kidney injury (SA‐AKI). We found that during SA‐AKI, reduced expression of DDX3x in renal tubular epithelial cells mediates histone delactylation, which in turn upregulates NINJ1 transcription and triggers tubular cell death. Conversely, Odetiglucan confers protection by
Hongyu Liang, Jihong Jiang, Huanxin Yin, Chunyan Liu, Hongjun Huang, Yan Luo, Minmin Zhu, Qiuyun Wang   +7 more
wiley   +1 more source

Successful treatment with sintilimab for SMARCA4-deficient non-small cell lung carcinoma: two case reports. [PDF]

Discov Oncol
Wang L, Ke H, Wang C, Wang K.
europepmc   +1 more source

Design and Application of Nanozymes: Current Trends and Cutting‐Edge Breakthroughs

Advanced Science, EarlyView.
Kelong Fan, Hui Wei, Xiyun Yan
wiley   +1 more source

Transcription Factor HOXC11 Drives Colorectal Cancer Progression and Metastasis via CAMK2A‐Dependent CXCL5 Upregulation

Advanced Science, EarlyView.
HOXC11 drives colorectal cancer progression by transcriptionally activating CAMK2A, which triggers NF‐κB–dependent CXCL5 upregulation. CXCL5–CXCR2 signaling further reinforces HOXC11 expression through the ERK1/2–SP1 axis, forming a prometastatic positive feedback loop that is effectively disrupted by combined CAMK2A and CXCR2 inhibition.
Qingyang Sun, Hengjie Xu, Sheng Yang, Jiahui Zhou, Chuanxin Tian, Hongxu Nie, Chi Jin, Tuo Wang, Zhihao Chen, Junwei Tang, Yifei Feng, Xiaowei Wang, Yueming Sun   +12 more
wiley   +1 more source

AHCYL1 mediates the tumor-promoting effect of PREX2 in non-small cell lung carcinoma. [PDF]

Theranostics
Lei M, Yeung YT, Nie W, Yang R, Li J, Chen H, Zhao R, Liu K, Dong Z.   +8 more
europepmc   +1 more source

NF-κB activation as a pro-survival signal from pharmacological inhibition of pyruvate dehydrogenase kinase 1 in non-small-cell lung carcinoma cell models. [PDF]

Transl Oncol
Liu Q, Ran M, Shan W, Zhang SL, Tam KY.
europepmc   +1 more source

Performance and considerations in the use of diagnostic mutation panels for clonality testing in non-small-cell lung carcinoma. [PDF]

ESMO Open
Janssen J, Andrade Barbosa B, Machado JC, Hofman P, Kim Y, Ylstra B, Radonic T.   +6 more
europepmc   +1 more source

Evaluation of TTF-1, Napsin A, p40, and p63 in the Subtyping of Non-Small Cell Lung Carcinoma: A Cross-Sectional Study from India. [PDF]

Iran J Pathol
Patel S, Anandarama Adiga DS.
europepmc   +1 more source

Role of Notch1 Signaling Pathway in Small Cell Lung Carcinoma. [PDF]

Iran J Pathol
Charbat MA, Abdulhalim YH, Alrabeei MA, Abdo Hassan W.   +3 more
europepmc   +1 more source