Results 221 to 230 of about 13,263,091 (289)

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

Reprogramming tumor cells with LCOR mRNA nanotherapy to enhance immunotherapy

Molecular Oncology, EarlyView.
LCOR (Ligand‐dependent corepressor) mRNA encapsulated in polymeric nanoparticles restores LCOR activity in tumor cells, constraining aggressive tumor cell states and increasing tumor immunogenicity. This reprogramming makes tumor cells more vulnerable to T‐cell attack and enhances their response to immune‐checkpoint immunotherapy.
Gabriel Serra‐Mir, Elena Haro‐Martínez, Sandra Blasco‐Benito, Chiara Cannatà, José Ángel Palomeque, Anna López‐Plana, Maria Sanz‐Flores, Marc Sabartés, Cristina Fornaguera, Toni Celià‐Terrassa   +9 more
wiley   +1 more source

Discovery of direct-acting small-molecule RIG-I agonists through creation of a selective CARD activation platform. [PDF]

Nat Commun
Guo R, Norford K, Xu L, Wei M, Wang W, Halene S, Pyle AM.   +6 more
europepmc   +1 more source

Optimization of seminal extracellular vesicle isolation protocols for cancer biomarker analysis using proteomic profiling

Molecular Oncology, EarlyView.
This paper shows that size‐exclusion chromatography and sequential centrifugation applied to seminal plasma enrich for different populations of extracellular vesicles. This may significantly affect the detection and analysis of extracellular vesicle‐associated cancer biomarkers.
Elen Telumyan, Beatriz Martín‐Gracia, Eva Bassols‐Citores, Krizia Sagini, Maria K. Andersen, Tuula A. Nyman, May‐Britt Tessem, Morten B. Rye, Alicia Llorente   +8 more
wiley   +1 more source

Immune checkpoints: cross-disease insights and clinical dilemmas. [PDF]

Biomark Res
Shu Y, Zhao JX, Guo BY, Liu Y, Zhou M, Ma N, Zhu CL, Zou Z.   +7 more
europepmc   +1 more source

Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy

Molecular Oncology, EarlyView.
We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley   +1 more source

Abdominal cocoon syndrome presenting with high-grade small bowel obstruction and postoperative intra-abdominal collection: a case report from Saudi Arabia. [PDF]

J Surg Case Rep
Binmoieql LY, Alomayyer A, Alotaibi S, Alshalfan RI, Almuqbil MS, Alsaab BA.   +5 more
europepmc   +1 more source

Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma

Molecular Oncology, EarlyView.
Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara, Kosuke Murakami, Shiro Takamatsu, Akiko Kanto, Seiichi Mori, Tomoyuki Otani, Kazuko Sakai, Yasushi Kotani, Kazuto Nishio, Kaoru Abiko, Noriomi Matsumura   +10 more
wiley   +1 more source

Long Noncoding RNA <i>H19</i> Inhibits Differentiation and Function of Secretory Lineage Cells in the Intestinal Epithelium by Targeting ATOH1. [PDF]

Noncoding RNA
Kwon MS, Chung HK, Chen H, VanderStoep A, Warner B, Zhao H, Atluri P, Tesfayohannes E, Turner DJ, Xiao L, Wang JY.   +10 more
europepmc   +1 more source

Rubicon is a critical regulator of immune barrier integrity and limits enteric pathogen infection. [PDF]

Front Immunol
Scaffidi AD, Scaffidi SJ, Carling J, Fajfer A, Ali M, Ono R, Hilyard A, Buksbaum RE, Kumar V, Shukla R, Mishra S, Jain S, Yadav H, Heckmann BL.   +13 more
europepmc   +1 more source