Results 91 to 100 of about 9,231,355 (310)
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Dynamic Crack Initiation Toughness of Shale under Impact Loading
Energies, 2019 The impact loading of a notched semi-circular bend (NSCB) specimen of outcrop shale in Changning Sichuan was carried out using a split Hopkinson pressure bar (SHPB) to study the effect of shale bedding on the dynamic crack initiation toughness.
Guoliang Yang +3 more
doaj +1 more source
Fatigue Property and Small Crack Propagation Mechanism of MIG Welding Joint of 6005A-T6 Aluminum Alloy. [PDF]
Materials (Basel), 2022 Peng Z, Yang S, Wang Z, Gao Z.
europepmc +1 more source
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
Jixie qiangdu, 2019 Crack is one common damage in key cantilever beam structures and early crack identification is much significant for increasing safety and reducing accidents. However, classical methods based on displacements are less sensitive to small cracks.
WAN Wen, LI GuangBu
doaj
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A Road Crack Detection Method Based on Residual and Attention Mechanism
Applied SciencesThis paper proposes a road crack detection method based on residual and attention mechanisms to address the issues of difficult detection of small cracks on road surfaces in complex backgrounds and inaccurate crack detection edges. This method introduces
Jianwu Xie +3 more
doaj +1 more source
Nihon Kikai Gakkai ronbunshu, 2017 It has been shown that rolling contact fatigue (RCF) test using specimen having a small drilled hole is a useful method for evaluating the effect of small defect on flaking strength of steels.
Sho HASHIMOTO +2 more
doaj +1 more source
Golgi enzymes are retrieved from the plasma membrane to the trans‐Golgi network
FEBS Letters, EarlyView.Golgi enzymes are traditionally considered resident proteins retained within the Golgi apparatus. Here, we demonstrate that a subset transiently reaches the cell surface and is subsequently retrieved to the trans‐Golgi network via retrograde transport. Using a nanobody‐based toolkit, we uncover a dynamic trafficking cycle of several Golgi enzymes.
Dominik P. Buser, Tina Junne
wiley +1 more source