Results 171 to 180 of about 10,630,553 (293)

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

A formulation dataset of poly(lactide-co-glycolide) nanoparticles for small molecule delivery

Scientific Data
Poly(lactide-co-glycolide) (PLGA) nanoparticles are promising drug delivery systems, widely recognized for their ability to overcome various limitations associated with conventional formulations.
Anita Goren, Zeqing Bao, Juan Pablo Martinez Lozano, Christine Allen   +3 more
doaj   +1 more source

Efficient Remote Sensing in Agriculture via Active Learning and Opt-HRDNet

IEEE Journal of Selected Topics in Applied Earth Observations and Remote Sensing
As the foundation of human survival, the development of agriculture has always played an important role in social development. The quality of agricultural development determines the speed of social progress.
Desheng Chen, Shuai Xiao, Meng Xi, Ling Dai, Jiachen Yang   +4 more
doaj   +1 more source

Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer

Molecular Oncology, EarlyView.
Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas, Barbara Karakyriakou, Patricia C. Muskus, Alyssa M. Roberts, Justin Rendleman, Alexa Warren, Hanxu Lu, Kimberly A. Birmingham, Malone K. Friedman, Abigail E. Goen, Huijuan Yang, Owen M. Wilkins, Fred W. Kolling, Eugene Demidenko, Julie M. Jorns, Brock C. Christensen, Todd W. Miller   +16 more
wiley   +1 more source

Large-scale human myeloma cell line small molecule compound screen dataset

Scientific Data
Multiple myeloma, a hematopoietic malignancy of terminally differentiated B cells, is the second most common hematological malignancy after leukemia.
V. Keith Hughitt, John K. Simmons, Sayeh Gorjifard, Aleksandra Michalowski, Kelli Wilson, Xiaohu Zhang, Paul Shinn, Carleen Klumpp-Thomas, Crystal McKnight, Zina Itkin, Lu Chen, Sam Michael, Jonathan Keats, Craig Thomas, Beverly A. Mock   +14 more
doaj   +1 more source

NFE-YOLO: A Lightweight and Efficient Detection Network for Low, Slow, and Small Drones

IEEE Access
With the rapid advancement of drone technology, there has been a significant increase in the demand for detecting “Low, Slow, and Small” (LSS) drones.
Dan Tian, Chen Wang, Dong Zhou, Xin Yan, Liaoyuan Zeng   +4 more
doaj   +1 more source

GVES: machine learning model for identification of prognostic genes with a small dataset. [PDF]

Sci Rep, 2021
Ko S, Choi J, Ahn J.
europepmc   +1 more source

Intrapatient tumour heterogeneity and clonal evolution in an autopsy study of metastatic salivary gland cancer

Molecular Oncology, EarlyView.
Tumour heterogeneity and clonal evolution of metastatic salivary gland cancer were evaluated in two patients with adenoid carcinoma and one patient with myoepithelial carcinoma. Radiology‐guided autopsy enabled multi‐region sampling (total samples n = 149), followed by whole‐genome sequencing and phylogenetic reconstruction (17 tumour samples, 4–7 per ...
Gerben Lassche, Niels J. van Ruitenbeek, Charlotte Adang, Luke O'Gorman, Pui Yuen Lee, Willemijn M. Klein, Adriana C. H. van Engen‐van Grunsven, Jack A. Schalken, Sander Bervoets, Gerald W. Verhaegh, Carla M. L. van Herpen   +10 more
wiley   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Improved machine learning performances with transfer learning to predicting need for hospitalization in arboviral infections against the small dataset. [PDF]

Neural Comput Appl, 2021
Ozer I, Cetin O, Gorur K, Temurtas F.
europepmc   +1 more source