Results 111 to 120 of about 538,751 (313)

Hyperosmotic stress‐induced redistribution of pre‐mRNA cleavage factor I subunits is associated with shifts in alternative polyadenylation

FEBS Open Bio, EarlyView.
Hyperosmotic stress triggers the relocation of the CFIm complex from the nucleus to the cytoplasm. This shift creates a nuclear ‘stoichiometric bottleneck’, limiting CFIm availability for mRNA processing. Consequently, specific mRNAs like NUDT21 and DICER1 undergo targeted 3′UTR shortening, demonstrating how spatial protein dynamics drive rapid ...
Hitomi Soumiya, Masatake Osawa, Hidefumi Fukumitsu   +2 more
wiley   +1 more source

Repair of Large Segmental Bone Defect using Vascularized Small Corticocancellous Bone in Rabbit Femur

, 2017
Background Although free-vascularized long-bone transfer is useful for reconstruction of a large segmental bone defect, it is limited by availability of transplantable bone, meticulous microsurgical technique, and donor-site morbidities ...
Jong Kang, Dong Suh, Soon Lee, Jung Park, Jong Park   +4 more
core   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Severe pulmonary hypertension associated with a small ventricular septal defect.

, 1983
A case of progressive pulmonary hypertension in a child with a small ventricular septal defect is presented. Natural history studies have indicated that children with small ventricular septal defects can be followed conservatively. This case represents a
S S Hirschfeld, G S Bisset
core   +1 more source

Calvarial Defect Healing Induced by Small Molecule Smoothened Agonist. [PDF]

, 2016
Hedgehog (Hh) signaling positively regulates both endochondral and intramembranous ossification. Use of small molecules for tissue engineering applications poses several advantages.
Shen, Jia, Lee, Min, Asatrian, Greg, Lee, Soonchul, Ting, Kang, Shrestha, Swati, Meyers, Carolyn, Nguyen, Alan, Soo, Chia, James, Aaron W, Nguyen, Vi, Pan, Hsin Chuan   +11 more
core   +1 more source

Aging Is a Key Driver for Adult Acute Myeloid Leukemia

Aging and Cancer, EarlyView.
Acute myeloid leukemia (AML) is a classical age‐related hematologic malignancy, and a key driver of AML is aging, which profoundly regulates intrinsic factors such as genomic instability, epigenetic reprogramming, and metabolic dysregulation, and alters bone marrow microenvironment.
Rong Yin, Haojian Zhang
wiley   +1 more source

Performance Analysis of Printed Circuit Board Defect Detection with Hybrid CNN Module Image Feature Extraction and Clustering

Eng
Accurate and efficient defect detection in printed circuit boards (PCBs) is critical for manufacturing quality control. Existing methods predominantly rely on manually extracted features such as surface texture, color, and shape for defect recognition ...
Fan Jiang, Huaching Chen, Songlin Wei, Chengying Chen   +3 more
doaj   +1 more source

Mutant NPM1 in Acute Myeloid Leukemia Initiation and Maintenance

Aging and Cancer, EarlyView.
NPM1 mutations drive acute myeloid leukemia by acting as neomorphic transcriptional regulators that cooperate with Menin–MLL and XPO1 to sustain HOX/MEIS1 expression and block differentiation. Targeting these mutant‐specific transcriptional dependencies provides a rational therapeutic strategy for NPM1‐mutated AML.
Yanan Jiang, Zhong Fan, Runmeng Liu, Xiaotian Zhang   +3 more
wiley   +1 more source

Risk Prediction Models for Recurrence After Curative Treatment of Early‐Stage or Locally Advanced Lung Cancer: A Systematic Review

Aging and Cancer, EarlyView.
This systematic review synthesizes prognostic models for survival and recurrence in resected non‐small cell lung cancer. While many models demonstrate moderate to good discrimination, few are externally validated and reporting quality is variable, limiting clinical applicability and highlighting the need for robust, transparent model development ...
Evangeline Samuel, S. Tissera, E. Paul, J. Zalcberg, R. G. Stirling   +4 more
wiley   +1 more source

YOLO-DST: MEMS Small-Object Defect Detection Method Based on Dynamic Channel–Spatial Modeling and Multi-Attention Fusion

Sensors
During the process of defect detection in Micro-Electro-Mechanical Systems (MEMSs), there are many problems with the metallographic images, such as complex backgrounds, strong texture interference, and blurred defect edges.
Qianwen Su, Hanshan Li
doaj   +1 more source