Results 41 to 50 of about 6,063,159 (289)

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

FEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge, Vivian Pogenberg, Alexander Baumgart, Bente Siebels, Hartmut Schlüter, Michael Hecht‐Bucher, Aymelt Itzen   +6 more
wiley   +1 more source

The heterodimeric amino acid transporters (HAT) of the SLC7/SLC3 family: A structure−function relationships and relevance to human pathology

FEBS Letters, EarlyView.
Heterodimeric amino acid transporters consist of SLC7 and SLC3 family proteins arranged in a conserved structural organization. They regulate nutrient transport across cell membranes, supporting essential cellular functions. These transporters also contribute to xenobiotic/drug uptake and distribution.
Mariafrancesca Scalise, Tiziano Mazza, Raffaella Scanga, Lara Console, Michele Galluccio, Cesare Indiveri   +5 more
wiley   +1 more source

Detection method of small size defects on pipeline weld surface based on improved YOLOv7.

PLoS ONE
The background of pipeline weld surface defect image is complex, and the defect size is small. Aiming at the small defect size in the weld image, which is easy to cause missed detection and false detection, a lightweight target detection algorithm based ...
Xiangqian Xu, Wenting Hou, Xing Li
doaj   +1 more source

Reconstructions of small scalp defects with step flap

Journal of Cutaneous and Aesthetic Surgery, 2017
Defects of the scalp arise from several aetiologies including trauma, burn, injury, infection, radiation and surgical excision of tumours. Multiple options for reconstruction of scalp defects exist that included primary closure, skin grafts, local flaps, regional and distal free flaps.This was a prospective case-series study, which was carried out in ...
Ebrahimi, Ali, Nejadsarvari, Nasrin, Ebrahimi, Azin   +2 more
openaire   +2 more sources

A context‐dependent modulatory role for eIF6 in acquired resistance to vemurafenib in melanoma

FEBS Letters, EarlyView.
Acquired resistance to vemurafenib upregulates the translation factor eIF6 in melanoma cells. Silencing eIF6 in resistant cells reduces proliferation and partially restores drug sensitivity, whereas its overexpression increases sensitivity across melanoma lines regardless of BRAF status, via modulation of mTOR, S6K, and MAPK signaling.
George Kyriakopoulos, Antonia Petropoulou, Alexandra Anastogianni, Angelina Bania, Vassilis Stamatakis, Argyris Alexiou, Chi‐Ping Day, Glenn Merlino, Katerina Grafanaki, Constantinos Stathopoulos   +9 more
wiley   +1 more source

Enhancing grid reliability through advanced insulator defect identification.

PLoS ONE
The article presents an innovative approach for detecting defects in insulators used in high-voltage power transmission lines, employing an enhanced Detection Transformer (DETR) model, termed IF-DETR.
Xiao Wang, Ting Yang, Yuntao Zou
doaj   +1 more source

Lightweight Detection Method of Wheelset Tread Defects Based on Improved YOLOv7

Applied Sciences
Accurate online inspection of train wheelset tread defects is challenging owing to the variety and position uncertainty of defects. This study develops an improved YOLOv7 model capable of inspecting various wheelset tread defects with high accuracy and ...
Peng Yang, Fan Gao, Xinwen Yang, Caidong Wang, Hongjun Yang, Zhifeng Zhang   +5 more
doaj   +1 more source

Reconstruction of Small Nasal Defects

Seminars in Plastic Surgery
AbstractThe nose maintains a central importance in both functional and aesthetic human anatomy. With such importance comes numerous possible defects with equally plentiful techniques available for repair. One of the most common causes for nasal reconstruction is Mohs micrographic surgery to excise basal and squamous cell carcinomas.
Hollier, Pierce, Parham, Matthew, Layon, Sarah A., Thornton, James F.   +3 more
openaire   +2 more sources

The ubiquitin system in normal and infected germinal center B cells

FEBS Letters, EarlyView.
The ubiquitin system plays a central role in germinal center (GC) B cells, influencing differentiation to long‐lived memory B cells. Oncogenic gammaherpesviruses gain access to memory B cells by establishing latency in GC B cells. Mapping ubiquitin mechanisms in normal and infected GC B cells will define specific molecular circuits in B cells germane ...
Destiny Davis, Lesly Mejia, Emily K Moser   +2 more
wiley   +1 more source

RST-YOLOv8: An Improved Chip Surface Defect Detection Model Based on YOLOv8

Sensors
Surface defect detection in chips is crucial for ensuring product quality and reliability. This paper addresses the challenge of low identification accuracy in chip surface defect detection, which arises from the similarity of defect characteristics ...
Wenjie Tang, Yangjun Deng, Xu Luo
doaj   +1 more source