Results 131 to 140 of about 6,412,011 (307)

Results of the determination of prevalence and intensities of included occlusion defects chewing localization, complicated convergences of the teeth their limiting

open access: yesЭндодонтия Today
AIM. Analyses the factors of prevalence and intensities of included occlusion defects chewing-oriented of localizations, complicated convergences teeth their limiting.MATERIALS AND METHODS.
G. G. Ashurov   +2 more
doaj   +1 more source

Defective Barrier on Voltage Optimization for Small Airgap

open access: yesBritish Journal of Applied Science & Technology, 2013
Aim: To investigate the effect of defective barrier on the optimum breakdown voltage, using positive and negative needle electrodes in an air medium of 10cm gap distance. Methodology: The barriers for the tests were placed at 2.5cm from the point electrode for each test.
openaire   +3 more sources

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw   +5 more
wiley   +1 more source

Temporal Interference Stimulation of Centromedian‐Parafascicular Complex in Disorders of Consciousness: A Pilot Study

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Treatment of disorders of consciousness (DoC) remains a major clinical challenge, and noninvasive, targeted modulation of deep brain structures has emerged as a promising therapeutic strategy. We aimed to evaluate the feasibility/safety and preliminary effects of thalamic temporal interference stimulation (TIS) targeting centromedian‐
Gengyao Hu   +7 more
wiley   +1 more source

Re‐Purposing Sapropterin (Kuvan) for ACTA2‐Related Multisystemic Smooth Muscle Dysfunction Syndrome: A Translational Mechanistic and First‐In‐Human Therapeutic Report

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Multisystemic smooth muscle dysfunction syndrome (MSMDS) is an ultra‐rare, ACTA2‐related disorder characterized by severe cerebrovascular disease, aortic aneurysms, and smooth muscle dysfunction. Using molecular dynamics simulations and in silico drug screening, we identified that sapropterin dihydrochloride (Kuvan) is a candidate capable of ...
Moran Hausman‐Kedem   +9 more
wiley   +1 more source

Autoimmune Comorbidities as Modifiers of Phenotypic Heterogeneity in Facioscapulohumeral Dystrophy

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral dystrophy type 1 (FSHD1) shows clinical heterogeneity that is only partly explained by D4Z4 repeat unit (RU) size. Although immune and inflammatory mechanisms may contribute to disease variability, the prevalence and clinical impact of autoimmune diseases in FSHD remain unclear.
Jonathan Pini   +9 more
wiley   +1 more source

Defect and fault tolerance techniques for nano-electronics

open access: yes, 2011
Nanotechnology-based devices are believed to be the future possible alternative to CMOS-based devices. It is predicted that the high integration density offered by emerging nanotechnologies will be accompanied by high manufacturing defect rates and high ...
Melouki, Aissa
core   +1 more source

Dysregulated Cholesterol Metabolism, Chronic Inflammation, and Disability in Severe Progressive Multiple Sclerosis

open access: yesAnnals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Dysregulated lipid metabolism, which can affect remyelination and neural repair, has not been extensively investigated in progressive multiple sclerosis (PMS). The goal was to examine whether dysregulated cholesterol metabolism was associated with disability in PMS. Methods The study sample comprised 53 Severe PMS patients (Expanded
Taylor R. Wicks   +8 more
wiley   +1 more source

Complex sine-Gordon theory: solitons, defects and boundaries [PDF]

open access: yes, 2008
This thesis presents research into the properties and features of the complex sine- Gordon theory. The CSG theory is a dimensional integrable held theory that admits soliton solutions which carry a Noether charge due to the U(I) invariance of the theory.
Umpleby, James
core  

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