Results 61 to 70 of about 538,751 (313)

PARK(ing) time–How park deficiency affects the biological clock in a Drosophila model of Parkinson's disease

open access: yesFEBS Letters, EarlyView.
Drosophila park mutants serve as a model for Parkinson's disease. We used this strain to investigate the connection between oxidative stress and the circadian clock mechanism. We showed that increased oxidative stress affects the physiology of pacemaker cells, disrupting their daily structural plasticity. Lack of rhythmic signaling from pacemaker cells
Kamila Zientara   +3 more
wiley   +1 more source

PCB-DETR: A Detection Network of PCB Surface Defect With Spatial Attention Offset Module

open access: yesIEEE Access
The paper proposes PCB-DETR, a novel detection network for PCB surface defect identification, which enhances the performance of small defect detection through improvements to the Deformable-DETR model.
Qifeng Li   +3 more
doaj   +1 more source

Retinoic Acid Activity in Undifferentiated Neural Progenitors Is Sufficient to Fulfill Its Role in Restricting Fgf8 Expression for Somitogenesis. [PDF]

open access: yesPLoS ONE, 2015
Bipotent axial stem cells residing in the caudal epiblast during late gastrulation generate neuroectodermal and presomitic mesodermal progeny that coordinate somitogenesis with neural tube formation, but the mechanism that controls these two fates is not
Thomas J Cunningham   +7 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

open access: yesFEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Small bowel obstruction caused by congenital transmesenteric defect

open access: yesAfrican Journal of Paediatric Surgery, 2011
Transmesenteric hernias are extremely rare. A strangulated hernia through a mesenteric opening is a rare operative finding. Preoperative diagnosis still is difficult in spite of the imaging techniques currently available.
Nouira F   +5 more
doaj  

Reconstruction of Small Soft Tissue Nasal Defects [PDF]

open access: yesSeminars in Plastic Surgery, 2013
Nasal defect repair has been one of the more challenging areas of reconstructive surgery due to the lack of uniform nasal skin thickness and complex contours. Currently, algorithms for medium to large nasal soft tissue defects have been well defined by various authors.
Erik M, Wolfswinkel   +3 more
openaire   +2 more sources

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

open access: yesMolecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Complex sine-Gordon theory: solitons, defects and boundaries [PDF]

open access: yes, 2008
This thesis presents research into the properties and features of the complex sine- Gordon theory. The CSG theory is a dimensional integrable held theory that admits soliton solutions which carry a Noether charge due to the U(I) invariance of the theory.
Umpleby, James
core  

Application of Modified Triangular Perforator Flap in Repair of Small and Medium-Sized Facial Defect

open access: yes, 2022
Ming-Zhu Gao,1,* Xin-Jian Xiang,2,* Mei Xiang3 1Department of Plastic Surgery, First Affiliated Hospital of Anhui Medical University, Hefei, People’s Republic of China; 2Department of Plastic Surgery, the Second Affiliated Hospital of Anhui ...
Xiang XJ, Gao MZ, Xiang M
core  

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