Results 41 to 50 of about 175,906 (292)

Thrombocytopenia in Small-for-Gestational-Age Infants [PDF]

Pediatrics, 2015
BACKGROUND: Thrombocytopenia is common among small-for-gestational-age (SGA) neonates (birth weight <10th percentile reference range), but several aspects of this thrombocytopenia are unclear, including the incidence, typical nadir, duration, association with preeclampsia, mechanism, and risk of death.
Robert D, Christensen, Vickie L, Baer, Erick, Henry, Gregory L, Snow, Allison, Butler, Martha C, Sola-Visner   +5 more
openaire   +2 more sources

Allosteric Modulation of Pathological Ataxin‐3 Aggregation: A Path to Spinocerebellar Ataxia Type‐3 Therapies

Advanced Science, EarlyView.
This study uncovers a new allosteric site in the Josephin domain of ataxin‐3 targeted by the molecular tweezer CLR01, which modulates protein aggregation, improves synaptic function in neuronal cells, and delays motor dysfunction in animal models.
Alexandra Silva, Sara Duarte‐Silva, Pedro M. Martins, Beatriz Rodrigues, Débora Serrenho, Daniela Vilasboas‐Campos, Andreia Teixeira‐Castro, Julio Vieyto‐Nuñez, Joel Mieres‐Perez, Francisco Figueiredo, Martyna Podlasiak, Tatiana Van‐der‐Kellen, Joana Fraga, James Noble, Carter Lantz, Niki Sepanj, Daniela Monteiro‐Fernandes, Sara Guerreiro, Andreia Neves‐Carvalho, Joana Pereira‐Sousa, Frank‐Gerrit Klärner, Thomas Schrader, Joseph A. Loo, Annalisa Pastore, Elsa Sanchez‐Garcia, Gal Bitan, Ana Luísa Carvalho, Patrícia Maciel, Sandra Macedo‐Ribeiro   +28 more
wiley   +1 more source

Prenatal exposure to tap water containing nitrate and the risk of small-for-gestational-age: A nationwide register-based study of Danish births, 1991–2015

Environment International, 2023
Background: Prenatal nitrate exposure from household tap water has been associated with increased risk of fetal growth restriction, preterm birth, birth defects, and childhood cancer.
Anja Søndergaard Jensen, Vanessa R. Coffman, Jörg Schullehner, Betina B. Trabjerg, Carsten B. Pedersen, Birgitte Hansen, Jørn Olsen, Marie Pedersen, Leslie T. Stayner, Torben Sigsgaard   +9 more
doaj   +1 more source

Genetic Analyses in Small-for-Gestational-Age Newborns [PDF]

The Journal of Clinical Endocrinology & Metabolism, 2018
Abstract Context Small for gestational age (SGA) can be the result of fetal growth restriction, which is associated with perinatal morbidity and mortality. Mechanisms that control prenatal growth are poorly understood.
Stalman, Susanne E., Solanky, Nita, Ishida, Miho, Alemán-Charlet, Cristina, Abu-Amero, Sayeda, Alders, Marielle, Alvizi, Lucas, Baird, William, Demetriou, Charalambos, Henneman, Peter, James, Chela, Knegt, Lia C., Leon, Lydia J., Mannens, Marcel M.A.M., Mul, Adi N., Nibbering, Nicole A., Peskett, Emma, Rezwan, Faisal I., Ris-Stalpers, Carrie, van der Post, Joris A.M., Kamp, Gerdine A., Plötz, Frans B., Wit, Jan M., Stanier, Philip, Moore, Gudrun E., Hennekam, Raoul C.   +25 more
openaire   +3 more sources

Bisphenol B Exposure Induces Miscarriage by Suppressing Migration/Invasion and Migrasome Formation

Advanced Science, EarlyView.
BPB (Bisphenol B) exposure up‐regulates ER (estrogen receptor) levels, enhances its interactions with the lnc‐HZ04 promoter region, and thus promotes ER‐mediated lnc‐HZ04 transcription. Subsequently, lnc‐HZ04 suppresses TCF4 (transcription factor 4)‐mediated PKCA (protein kinase C alpha) transcription and subsequently suppresses migration/invasion and ...
Wenxin Huang, Manli Wang, Yi Sun, Xiaoping Yue, Xun Li, Yanbing Lin, Geng Guo, Depeng Zhao, Qigang Fan, Xiaoling Ma, Zhihong Zhang, Shuaishuai Xing, Xiaoting Shen, Huidong Zhang   +13 more
wiley   +1 more source

Early pregnancy metabolic syndrome and risk for adverse pregnancy outcomes: findings from Rajarata Pregnancy Cohort (RaPCo) in Sri Lanka

BMC Pregnancy and Childbirth, 2023
Background Despite the intergenerational effects of metabolic disorders, evidence is greatly lacking on early pregnancy metabolic syndrome (MetS) and its effects on pregnancy outcomes from low- and middle-income countries.
Imasha Upulini Jayasinghe, Thilini Chanchala Agampodi, Ajith Kumara Dissanayake, Suneth Buddhika Agampodi   +3 more
doaj   +1 more source

Hyperandrogenemia Induces Trophoblast Ferroptosis and Early Pregnancy Loss in Patients With PCOS via CMA‐Dependent FTH1 Degradation

Advanced Science, EarlyView.
In PCOS patients with hyperandrogenemia, decreased ferritin heavy chain 1 (FTH1) causes Fe2⁺ overload and ferroptosis in trophoblasts. Androgens induce FTH1 protein degradation via AR‐LAMP2A‐mediated chaperone‐mediated autophagy pathway, leading to placental development disruption and early pregnancy loss. Metformin mitigates androgen‐induced placental
Hanjing Zhou, Weijie Yang, Na Liu, Qing Liu, Jiamin Jin, Chenqiong Zhao, Xiaoying Jin, Miao Gui, Haiyan Zhu, Songying Zhang, Yinli Zhang   +10 more
wiley   +1 more source

Use of a Feed-Forward Back Propagation Network for the Prediction of Small for Gestational Age Newborns in a Cohort of Pregnant Patients with Thrombophilia

Diagnostics, 2022
(1) Background: Fetal growth restriction is a relatively common disorder in pregnant patients with thrombophilia. New artificial intelligence algorithms are a promising option for the prediction of adverse obstetrical outcomes.
Petronela Vicoveanu, Ingrid Andrada Vasilache, Ioana Sadiye Scripcariu, Dragos Nemescu, Alexandru Carauleanu, Dragos Vicoveanu, Ana Roxana Covali, Catalina Filip, Demetra Socolov   +8 more
doaj   +1 more source

Nanoscale Mapping of the Subcellular Glycosylation Landscape

Advanced Science, EarlyView.
Using multiplexed super‐resolution imaging with fluorophore‐labeled lectins, this study reports intracellular glycosylation at the nanoscale across organelles and synaptic specializations. Extending glycan analysis beyond the cell surface, Glyco‐STORM reveals distinct glycosylation nanodomains in the ER, Golgi, lysosomes, and synaptic sites.
Helene Gregoria Schroeter, Steffen Sass, Mike Heilemann, Thomas Kuner, Maja Klevanski   +4 more
wiley   +1 more source

Perinatal factors impacting echocardiographic left ventricular measurement in small for gestational age infants: a prospective cohort study

BMC Pediatrics, 2023
Introduction Infants born small for gestational age (SGA) have an increased risk of developing various cardiovascular complications. While many influencing factors can be adjusted or adapt over time, congenital factors also have a significant role.
Ibrahim Elmakaty, Ahmed Amarah, Michael Henry, Manoj Chhabra, Danthanh Hoang, Debbie Suk, Nitin Ron, Beata Dygulska, Farrah Sy, Madhu B. Gudavalli, Ali M. Nadroo, Pramod Narula, Ashraf Gad   +12 more
doaj   +1 more source