Results 111 to 120 of about 4,312,405 (312)

Metabolomics opens a window to investigate the biological function of small molecules

, 2012
Metabolomics opens a window to investigate the biological function of small ...
许国旺, 陈静, 赵欣捷, 尹沛源, 吴泽明, 路鑫   +5 more
core  

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

FEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li, Pedro A. Sánchez‐Murcia, Bernd Nidetzky   +2 more
wiley   +1 more source

Small-Airway Function Variables in Spirometry, Fractional Exhaled Nitric Oxide, and Circulating Eosinophils Predicted Airway Hyperresponsiveness in Patients with Mild Asthma

Journal of Asthma and Allergy, 2021
Wuping Bao,1,* Xue Zhang,1,* Junfeng Yin,2,* Lei Han,1,* Zhixuan Huang,2 Luhong Bao,1 Chengjian Lv,1 Huijuan Hao,1 Yishu Xue,1 Xin Zhou,1 Min Zhang1 1Department of Respiratory and Critical Care Medicine, Shanghai General Hospital, Shanghai Jiao Tong ...
Bao W, Zhang X, Yin J, Han L, Huang Z, Bao L, Lv C, Hao H, Xue Y, Zhou X, Zhang M   +10 more
doaj  

Uniqueness of meromorphic functions sharing one small function

Journal of Computational and Applied Mathematics, 2014
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
Li Rui Jie, Qiu Ling, Zuxing Xuan
openaire   +2 more sources

Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator

, 2008
We have carried out a cell-based screen aimed at discovering small molecules that activate p53 and have the potential to decrease tumor growth. Here, we describe one of our hit compounds, tenovin-1, along with a more water-soluble analog, tenovin-6.
Campbell, Johanna, Murray, Karen E., Stark, Michael J.R., Lain, Sonia, Stark, Michael J. R., Baker, Lee, Appleyard, Virgina, Higgins, Maureen, Pass, Georgia, Mathers, Joanne, Lane, David P., Staples, Oliver D., Woods, Julie, McCarthy, Anna, Holland, Stephen J., Hollick, Jonathan J., Aoubala, Mustapha, Thompson, Alastair, Westwood, Nicholas J., Appleyard, Virginia   +19 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Complex small entire functions

Mathematics Open
Small functions were defined in complex analysis together with the notions of order of growth, lower order of growth, type of growth and lower type of growth. The set of small entire functions with respect to an entire function f is a [Formula: see text]-algebra.
openaire   +2 more sources

The syntax of small clause predication

, 2013
In this paper I put forward and justify a syntactic configuration that I call Complex Small Clause-structure. I show that this single syntactic structure can explain both the semantic value and the syntactic behavior of a range of constructions that up ...
Rafel, Joan
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The function of tRNA-derived small RNAs in cardiovascular diseases

Molecular Therapy: Nucleic Acids
tRNA-derived small RNAs (tsRNAs) constitute a subgroup of small noncoding RNAs (ncRNAs) originating from tRNA molecules. Their rich content, evolutionary conservatism, high stability, and widespread existence makes them significant in disease research ...
Yan Zhao, Kai Wang, Chun Zhao, Ning Liu, Zhihong Wang, Wenting Yang, Zewei Cheng, Luyu Zhou, Kun Wang   +8 more
doaj   +1 more source