Results 241 to 250 of about 10,910,180 (370)

Inhibitor of DNA binding‐1 is a key regulator of cancer cell vasculogenic mimicry

Molecular Oncology, EarlyView.
Elevated expression of transcriptional regulator inhibitor of DNA binding 1 (ID1) promoted cancer cell‐mediated vasculogenic mimicry (VM) through regulation of pro‐angiogenic and pro‐cancerous genes (e.g. VE‐cadherin (CDH5), TIE2, MMP9, DKK1). Higher ID1 expression also increased metastases to the lung and the liver.
Emma J. Thompson, Emma L. Dorward, Kristyn Jurrius, Nathalie Nataren, Markus Tondl, Kay K. Myo Min, Michaelia P. Cockshell, Anahita Fouladzadeh, John Toubia, Mark DeNichilo, Delphine Merino, Claudine S. Bonder   +11 more
wiley   +1 more source

Lung function decline and incidence of chronic obstructive pulmonary disease in participants with spirometry-defined small airway dysfunction: a 15-year prospective cohort study in China. [PDF]

Respir Res
Zhou Y, Wu F, Deng Z, Wang Z, Tian H, Huang P, Zheng Y, Yang H, Zhao N, Dai C, Yang C, Yu S, Tian J, Cui J, Liu S, Wang D, Wang X, Lu J, Zhong N, Ran P.   +19 more
europepmc   +1 more source

MET and NF2 alterations confer primary and early resistance to first‐line alectinib treatment in ALK‐positive non‐small‐cell lung cancer

Molecular Oncology, EarlyView.
Alectinib resistance in ALK+ NSCLC depends on treatment sequence and EML4‐ALK variants. Variant 1 exhibited off‐target resistance after first‐line treatment, while variant 3 and later lines favored on‐target mutations. Early resistance involved off‐target alterations, like MET and NF2, while on‐target mutations emerged with prolonged therapy.
Jie Hu, Ning Ding, Xiaobo Xu, Yedan Chen, Yong Zhang, Jingwen Liu, Jiebai Zhou, Hairong Bao, Donghui Zhang, Yijun Song, Yang Shao, Yuanlin Song   +11 more
wiley   +1 more source

Automated Detection of Micro-Scale Porosity Defects in Reflective Metal Parts via Deep Learning and Polarization Imaging. [PDF]

Nanomaterials (Basel)
Li H, Peng X, Wang B, Shi F, Xia Y, Li S, Shan C, Li S.   +7 more
europepmc   +1 more source

Chemoresistome mapping in individual breast cancer patients unravels diversity in dynamic transcriptional adaptation

Molecular Oncology, EarlyView.
This study used longitudinal transcriptomics and gene‐pattern classification to uncover patient‐specific mechanisms of chemotherapy resistance in breast cancer. Findings reveal preexisting drug‐tolerant states in primary tumors and diverse gene rewiring patterns across patients, converging on a few dysregulated functional modules. Despite receiving the
Maya Dadiani, Gilgi Friedlander, Gili Perry, Nora Balint‐Lahat, Shlomit Gilad, Dana Morzaev‐Sulzbach, Anjana Shenoy, Noa Bossel Ben‐Moshe, Anya Pavlovsky, Rinat Bernstein‐Molho, Eytan Domany, Iris Barshack, Tamar Geiger, Bella Kaufman, Einav Nili Gal‐Yam   +14 more
wiley   +1 more source

Small peptides activate the latent sequence-specific DNA binding function of P53 [PDF]

, 1996

openalex   +1 more source

Tonic signaling of the B‐cell antigen‐specific receptor is a common functional hallmark in chronic lymphocytic leukemia cell phosphoproteomes at early disease stages

Molecular Oncology, EarlyView.
B‐cell chronic lymphocytic leukemia (B‐CLL) and monoclonal B‐cell lymphocytosis (MBL) show altered proteomes and phosphoproteomes, analyzed using mass spectrometry, protein microarrays, and western blotting. Identifying 2970 proteins and 316 phosphoproteins, including 55 novel phosphopeptides, we reveal BCR and NF‐kβ/STAT3 signaling in disease ...
Paula Díez, Pablo Juanes‐Velasco, Marina L. García‐Vaquero, Conrad Droste, Alicia Landeira‐Viñuela, Miguel Alcoceba, Helena Fidalgo‐Gómez, Sara Misiego‐Herrero, Almudena Navarro‐Bailón, Mónica Baile, José M. Bastida, Jose Manuel Sanchez‐Santos, Rafael Góngora, Julia Almeida, Marcos Gonzalez‐Diaz, Alberto Orfao, Javier De Las Rivas, Manuel Fuentes   +17 more
wiley   +1 more source

MAFB: a key regulator of myeloid commitment involved in hematological diseases. [PDF]

Cell Death Discov
Ventura AB, Loconte T, Negri A, Viggiano L, Fiermonte G, Ciavarella S, Guarini A, Volpe G.   +7 more
europepmc   +1 more source

Scaling violations of the proton structure function F2 at small x

, 1994
I. Abt, T. Ahmed, V. Andreev, B. Andrieu, R.D. Appuhn, M. Arpagaus, A. Babaev, H. Bärwolff, J. Bán, P. Baranov, E. Barrelet, W. Bartel, U. Bassler, H. P. Beck, H.‐J. Behrend, A. Belousov, Ch. Berger, H. Bergstein, G. Bernardi, R. Bernet, G. Bertrand-Coremans, M. Besançon, P. Biddulph, E. Binder, A. Bischoff, J.C. Bizot, V. Blobel, K. Borras, P. Bosetti, V. Boudry, C. Bourdarios, F. Brasse, U. Braun, W. Braunschweig, D. Bruncko, L. Büngener, J. Bürger, F.W. Büsser, A. Buniatian, S. Bürke, G. Buschhorn, Alan Campbell, T. Carli, F. Charles, D. Clarke, A.B. Clegg, M. Colombo, J. A. Coughlan, A. Courau, C. Coutures, G. Cozzika, L. Criegee, J. Cvach, S. Dagoret-Campagne, J.B. Dainton, M. Danilov, A.W.E. Dann, W.D. Dau, M. David, E. Deffur, B. Delcourt, L. Del Buono, M. Devel, A. De Roeck, P. Dingus, C. Dollfus, J.D. Dowell, H.B. Dreis, A. Drescher, J. Duboc, D. Düllmann, O. Dünger, H.H. Duhm, R. Ebbinghaus, Manfred Eberle, J. Ebert, T.R. Ebert, G. Eckerlin, V. Efremenko, S. Egli, S. Eichenberger, R. Eichler, F. Eisele, E. Eisenhandler, N. Ellis, R.J. Ellison, E. Elsen, M. Erdmann, E. Evrard, L. Favart, A. Fedotov, D. Feeken, R. Felst, J. Feltesse, I.F. Fensome, J. Ferencei, F. Ferrarotto, K. Flamm, W. Flauger, M. Fleischer   +99 more
openalex   +1 more source

How fast do small x structure functions rise? A comparative analysis [PDF]

, 1999
P. Desgrolard, L. L. Jenkovszky, A. Lengyel, F. Paccanoni   +3 more
openalex   +1 more source