Results 271 to 280 of about 28,138,831 (356)

Can assessment of small airway dysfunction support the diagnosis or management of asthma exacerbations in children? A systematic review. [PDF]

BMC Pulm Med
Alshehri A, Alshahrani MI, Sapey E, Stockley R, Almeshari M.   +4 more
europepmc   +1 more source

Liquid biopsy epigenetics: establishing a molecular profile based on cell‐free DNA

Molecular Oncology, EarlyView.
Cell‐free DNA (cfDNA) fragments in plasma from cancer patients carry epigenetic signatures reflecting their cells of origin. These epigenetic features include DNA methylation, nucleosome modifications, and variations in fragmentation. This review describes the biological properties of each feature and explores optimal strategies for harnessing cfDNA ...
Christoffer Trier Maansson, Anders Lade Nielsen, Boe Sandahl Sorensen   +2 more
wiley   +1 more source

Ion diffusion overestimates figures of merit in polymeric mixed conductors. [PDF]

Nat Commun
Shahi M, Le VN, Alarcon Espejo P, Ding B, Bombile JH, Risko C, Heeney M, Paterson AF.   +7 more
europepmc   +1 more source

Intein‐based modular chimeric antigen receptor platform for specific CD19/CD20 co‐targeting

Molecular Oncology, EarlyView.
CARtein is a modular CAR platform that uses split inteins to splice antigen‐recognition modules onto a universal signaling backbone, enabling precise, scarless assembly without re‐engineering signaling domains. Deployed here against CD19 and CD20 in B‐cell malignancies, the design supports flexible multi‐antigen targeting to boost T‐cell activation and
Pablo Gonzalez‐Garcia, Noelia Moares, Wenjie Yi‐He, Rosa Luna‐Espejo, Ricardo Fernandez‐Cisnal, Javier Ocaña‐Cuesta, Juan P. Muñoz‐Miranda, Antonio Gabucio, Cecilia M. Fernandez‐Ponce, Francisco Garcia‐Cozar   +9 more
wiley   +1 more source

Spontaneous Cholesterol Embolism Presenting as Acute Kidney Injury: A Nephrology Approach and Literature Review. [PDF]

J Investig Med High Impact Case Rep
Nguyen NP, Le TDV, Nguyen N, Chakraborty A, Nguyen TT, Tran TMQ, Nguyen NDP, Bui ACM, Vu AL.   +8 more
europepmc   +1 more source

Reduced Lung Function and Cerebral Small Vessel Disease in Japanese Men: the Shiga Epidemiological Study of Subclinical Atherosclerosis (SESSA)

, 2018
Ruriko Seto-Yukimura, Emiko Ogawa, Takashi Hisamatsu, Sayuki Torii, Akihiko Shiino, Kazuhiko Nozaki, Akira Fujiyoshi, Katsuyuki Miura, Yasutaka Nakano, Hirotsugu Ueshima   +9 more
openalex   +2 more sources

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

Association between diffusion tensor imaging analysis along the perivascular space (DTI-ALPS)-based glial-lymphatic dysfunction and cognitive impairment in non-small cell lung cancer. [PDF]

Am J Transl Res
Shao W, Li Z, Ge Y, Hu S, Lu H.
europepmc   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

SLR-Net: Lightweight and Accurate Detection of Weak Small Objects in Satellite Laser Ranging Imagery. [PDF]

Sensors (Basel)
Zhu W, Hu J, Gong W, Wang Y, Zhang Y.
europepmc   +1 more source