Results 211 to 220 of about 222,198 (258)
Some of the next articles are maybe not open access.
RNA interference and chemically modified small interfering RNAs
Current Opinion in Chemical Biology, 2004RNA interference (RNAi) is a powerful biological process for specific silencing of gene expression in diversified eukaryotic cells and has tremendous potential for functional genomics, drug discovery through in vivo target validation, and development of novel gene-specific medicine.
Muthiah Manoharan
exaly +3 more sources
Chemical Modification of Small Interfering RNA
2011Chemically synthesized siRNAs are widely used for gene silencing. For in vitro applications, stability, delivery, and immunological issues are rarely problematic, but for in vivo applications the situation is different. Limited stability, undesirable pharmacokinetic behaviour, and unanticipated side effects from the immune system call for more careful ...
Bramsen, Jesper Bertram +1 more
openaire +2 more sources
RNA Interference and Small Interfering RNAs
ChemBioChem, 2001The term aRNA interferenceo (RNAi) was coined after the groundbreaking discovery that injection of double-stranded RNA (dsRNA) into the nematode Caenorhabditis elegans leads to specific silencing of genes highly homologous in sequence to the delivered dsRNA.
openaire +3 more sources
The Role of Small Interfering RNAs in Hepatocellular Carcinoma
Journal of Gastrointestinal Cancer, 2023Hepatocellular carcinoma (HCC), a primary liver cancer with high mortality, is the most common malignant tumor in the world. Currently, the effect of routine treatment is poor, especially for this kind of cancer with strong heterogeneity and late detection.
Feng, Chen +4 more
openaire +2 more sources
Small Interfering RNAs and RNA Therapeutics in Cardiovascular Diseases
2020Ribonucleic acid (RNA) is being exploited and understood in its many aspects of function and structure for development of valuable tools in the therapeutics of various diseases such as cardiovascular etc. The expanded knowledge regarding function of RNA in the genomics and inside the cell has dramatically changed the therapeutic strategies in the past ...
Parveen, Bansal, Malika, Arora
openaire +2 more sources
Oncogene Suppression by Small Interfering RNAs
Current Pharmaceutical Biotechnology, 2004Almost all human cancers have accumulated multiple genetic lesions including oncogenes. It is often unknown whether an oncogene is continuously required for tumorigenesis. Furthermore, it is very difficult to target an essential oncogene with drugs without affecting the corresponding nonmutated protooncogene or related factors.
openaire +3 more sources
Small interfering RNA (siRNA)-based therapeutics
Drug and Therapeutics Bulletin, 2023In early studies in simple organisms and mammalian cell lines, small interfering RNA (siRNA) molecules were found to allow experimental cleavage of intracellular messenger RNA (mRNA; the transcription product of a cell gene), reducing the levels of the proteins that would otherwise be formed by the action of the mRNA, thereby ‘silencing’ a specific ...
openaire +2 more sources
Gene silencing in mammals by small interfering RNAs
Nature Reviews Genetics, 2002Among the 3 billion base pairs of the human genome, there are approximately 30,000-40,000 protein-coding genes, but the function of at least half of them remains unknown. A new tool - short interfering RNAs (siRNAs) - has now been developed for systematically deciphering the functions and interactions of these thousands of genes.
Michael T, McManus, Phillip A, Sharp
openaire +2 more sources
Ribozymes, DNAzymes and Small Interfering RNAs as Therapeutics
Current Drug Targets, 2005Selective gene silencing by nucleic acid enzymes has provided researchers with a new strategy to block gene expression and drug target validation. Ribozymes, DNAzymes and small interfering RNAs (siRNAs) are being explored as genetic inhibitors of gene expression as well as potential therapeutics against viral infections, inflammatory disorders ...
Mouldy, Sioud, Per Ole, Iversen
openaire +2 more sources