Results 151 to 160 of about 5,697,122 (302)

Making the Case for Organ‐on‐Chip Platforms in Long‐Acting Therapeutics Development

Advanced Healthcare Materials, EarlyView.
LATs release drug from a tissue‐resident depot over weeks to months, improving adherence, but their development is hampered by preclinical models that cannot reproduce the coupled tissue processes, sustained release, local microenvironment change, interstitial transport, immune and foreign‐body responses, and clearance that govern depot performance in ...
Charlie Gowans, Abdulwahhab Khedr, Panagiotis G. Georgiou, Nehir Arik, Ozlem Sen, Steve P. Rannard, Tom O. McDonald, Christos Tapeinos   +7 more
wiley   +1 more source

Mapping mesenchymal diversity in the human small intestine and organoids. [PDF]

Nat Cell Biol
Johnson KF, Dong X, Tsai YH, Wu A, Clark SG, Vallie A, Huang S, Childs CJ, Zwick RK, Glass I, Walton KD, Klein OD, Spence JR.   +12 more
europepmc   +1 more source

Water‐Activated Phospholipid Phase‐Separation Gel as an Immunomodulatory Anti‐Adhesion Barrier for Postoperative Adhesion Prevention

Advanced Healthcare Materials, EarlyView.
A water‐activated phospholipid phase‐separation gel is repurposed as a drug‐free surgical barrier for postoperative adhesion prevention. Propylene glycol promotes rapid lamellar gel reinforcement, prolonged local retention, and tissue coverage, while phosphatidylcholine‐mediated immunomodulation suppresses inflammatory and fibrotic responses. This dual‐
Jong‐Ju Lee, Yulseung Sung, Yeji Kim, Heesang Yang, Suyeon Pyo, Byeol Yun, Sung‐Joo Hwang   +6 more
wiley   +1 more source

Golgi organization regulates stem cell function in the small intestine. [PDF]

Nat Commun
Belevich I, Porcile L, Sola-Carvajal A, Grommisch D, Annusvar K, Heinz P, Das S, Webb AT, Andersson S, Pentinmikko N, Villablanca EJ, Goldenring JR, Kasper M, Jokitalo E, Coffey RJ, Katajisto P, Scharaw S.   +16 more
europepmc   +1 more source

Lignin Mimicking Protein Methylation Augments the Efficacy of FOLFOX Chemotherapy by Anchoring Thymidylate Synthase

Advanced Materials, EarlyView.
Lignin‐mimicking protein methylation can enhance the efficacy and mitigate the toxicity of the classic FOLFOX chemotherapy regimen. ABSTRACT FOLFOX has served as the standard chemotherapy regimen for advanced stages, specifically in the treatment of pancreatic, colorectal, and bladder cancers.
Shiyao Song, Yan‐Lai Tang, Xiaoting Liu, Jiayi Zheng, Chong Wu, Tang Li, Junhong Ye, Dianmin Xia, Yong Mei, Jingxuan Ma, Libin Huang, Xuequn Luo, Liheng Chen, Yanlin Qin, Weiling He   +14 more
wiley   +1 more source

The role of enteroscopy in the diagnosis and interventional management of small intestine diseases. [PDF]

Ther Adv Gastroenterol
Huszcza B, Grabowska K, Romańczyk T, Małecka-Wojciesko E.   +3 more
europepmc   +1 more source

Organic Materials of Tomorrow: Horizons of Artificial Intelligence

Advanced Materials, EarlyView.
This review examines machine learning techniques accelerating the discovery of organic semiconductors by linking molecular structure to properties. Key methods include graph neural networks, generative models, and active learning. Applications to organic photovoltaics demonstrate practical impact.
Harold Mena, J. Terence Blaskovits, Kun‐Han Lin, Denis Andrienko   +3 more
wiley   +1 more source

<i>Salmonella</i> lipopolysaccharide stimulates uptake of long-chain fatty acids in the small intestine. [PDF]

Proc Natl Acad Sci U S A
Koo E, Quinn G, Behrendt CL, Hassell B, Kang KN, Ruhn KA, Vale G, McDonald JG, Zhu W, Winter SE, Hooper LV.   +10 more
europepmc   +1 more source

Biointegrated Battery‐Based Electroceuticals

Advanced Materials, EarlyView.
Biointegrated batteries go beyond passive power to serve as active therapeutic platforms for delivering programmable electrical cues and bioactive agents. This review examines their mechanisms and applications and provides a framework to guide battery‐based therapeutic design and clinical translation.
Yan Zhou, Zhilian Yue, Zhiqi Chen, Danming Chao, Xiaoteng Jia, Gordon Wallace, Caiyun Wang   +6 more
wiley   +1 more source

Undifferentiated pleomorphic sarcoma of the small intestine presenting with intussusception in a patient with prior well-differentiated liposarcoma. [PDF]

J Surg Case Rep
Otsu S, Murao Y, Shiraki H, Tsutsumi A, Endo Y, Nakatsuka SI.   +5 more
europepmc   +1 more source