Results 131 to 140 of about 18,391,078 (250)

Integrative in silico and in vitro screening of small molecules targeting RNA. [PDF]

Curr Protoc
Toews S, Ken M, Schwalbe H.
europepmc   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Purine and Pyrrolopyrimidine-Based Small Molecules as Multitarget Therapeutics. [PDF]

Arch Pharm (Weinheim)
Borghi F, Laus A, Sorbi C, Rastelli G.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Recent progress in small molecules targeting the acidic tumor microenvironment. [PDF]

J Enzyme Inhib Med Chem
Fu Y, Song J, Yu C, Guo Y, Tang B, Yang G, Zheng Y, Wang Q.   +7 more
europepmc   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Phenotypic screening for small molecules that lower PrP in cultured cells. [PDF]

Mol Cell Neurosci
Frei JA, Reidenbach AG, Xu LMH, Gopalakrishnan RM, Casalana D, Sprague DA, Bray MA, Wang AQ, Laversenne V, Erickson B, Braun C, Hall M, Auld D, Minikel EV, Vallabh SM.   +14 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Generative Chemistry Platform for Small Molecules Targeting RNA: A Case Study for Chemical Optimization. [PDF]

Comput Struct Biotechnol J
Allen TEH, Boyd SM, Bonnet M, Khan RT.
europepmc   +1 more source

Supramolecular Helical Systems: Helical Assemblies of Small Molecules, Foldamers, and Polymers with Chiral Amplification and Their Functions.

Chemical Reviews, 2016
E. Yashima, N. Ousaka, Daisuke Taura, Kouhei Shimomura, T. Ikai, Katsuhiro Maeda   +5 more
semanticscholar   +1 more source