Results 21 to 30 of about 18,391,078 (250)

A BOILED‐Egg To Predict Gastrointestinal Absorption and Brain Penetration of Small Molecules

ChemMedChem, 2016
Apart from efficacy and toxicity, many drug development failures are imputable to poor pharmacokinetics and bioavailability. Gastrointestinal absorption and brain access are two pharmacokinetic behaviors crucial to estimate at various stages of the drug ...
A. Daina, V. Zoete
semanticscholar   +1 more source

Targeting RNA with small molecules: from fundamental principles towards the clinic

Chemical Society Reviews, 2021
Recent advances in our understanding of RNA biology have uncovered crucial roles for RNA in multiple disease states, ranging from viral and bacterial infections to cancer and neurological disorders.
James P. Falese, A. Donlic, A. Hargrove
semanticscholar   +1 more source

Acknowledgment to Reviewers of Molecules in 2020

, 2021
Peer review is the driving force of journal development, and reviewers are gatekeepers who ensure that Molecules maintains its standards for the high quality of its published papers [...
Molecules Editorial Office Molecules Editorial Office
core   +1 more source

The Investigation of the Chemical Composition and Applicability of Gold Nanoparticles Synthesized with Amygdalus communis (Almond) Leaf Aqueous Extract as Antimicrobial and Anticancer Agents

, 2023
The current work’s main objective was to determine the chemical composition of Amygdalus communis (AC) leaf extract and examine the antibacterial and cytotoxic properties of biosynthesized gold nanoparticles (AuNPs).
Keskin, Cumali, Mehmet Fırat Baran, Cumali Keskin, Ayşe Baran, Aziz Eftekhari, Sabina Omarova, Rovshan Khalilov, Mehmet Tevfik Adican, Gvozden Rosić, Dragica Selakovic, Mahmut Yıldıztekin, Kadri Kurt, Canan Aytuğ Ava, Mehmet Nuri Atalar   +1 more
core   +1 more source

Values in Small Molecules and Proteins

, 2021
[Image: see text] Accurately determining the acid dissociation constants (K(a) or their logarithmic form, pK(a)) of small molecules and large biomolecules has proven to be pivotal for the study different biological processes and developing new drugs ...
0000-0003-0105-4337, Gonzalo Jiménez-Osés, Claudio D. Navo, Navo, Claudio D., 0000-0003-0161-412X, Navo, Claudio D., Jiménez-Osés, Gonzalo   +6 more
core   +1 more source

Pharmacological Potential of Small Molecules for Treating Corneal Neovascularization

, 2020
Under healthy conditions, the cornea is an avascular structure which allows for transparency and optimal visual acuity. Its avascular nature is maintained by a balance of proangiogenic and antiangiogenic factors.
Bomina Park, Corson, Timothy W., Zachary Barry, Timothy W. Corson, Barry, Zachary, Park, Bomina   +5 more
core   +1 more source

FoldX 5.0: working with RNA, small molecules and a new graphical interface

Bioinform., 2019
Summary A new version of FoldX, whose main new features allows running classic FoldX commands on structures containing RNA molecules and includes a module that allows parametrization of ligands or small molecules (ParamX) that were not previously ...
Javier Delgado, L. Radusky, D. Cianferoni, L. Serrano   +3 more
semanticscholar   +1 more source

Green Synthesis of Silver Nanoparticles from Allium cepa L. Peel Extract, Their Antioxidant, Antipathogenic, and Anticholinesterase Activity

, 2023
The present work deals with the green synthesis and characterization of silver nanoparticles (AgNPs) using Allium cepa (yellowish peel) and the evaluation of its antimicrobial, antioxidant, and anticholinesterase activities.
Keskin, Cumali, Mehmet Fırat Baran, Ayşe Baran, Abdulkerim Hatipoğlu, Mahmut Yildiztekin, Selçuk Küçükaydin, Kadri Kurt, Hülya Hoşgören. Moklesur Rahman Sarker, Albert Sufianov, Ozal Beylerli, Rovshan Khalilov, Aziz Eftekhari   +1 more
core   +1 more source

RNA Drugs and RNA Targets for Small Molecules: Principles, Progress, and Challenges

Pharmacological Reviews, 2020
RNA-based therapies, including RNA molecules as drugs and RNA-targeted small molecules, offer unique opportunities to expand the range of therapeutic targets.
Ai-Ming Yu, Young Hee Choi, Mei-Juan Tu
semanticscholar   +1 more source

Benchmarking tandem mass spectra of small natural product molecules via ab initio molecular dynamics [PDF]

, 2023
Natural products have proven to be valuable, particularly in the fields of drug discovery and chemogenomics. Tandem mass spectrometry, along with reference mass spectral libraries, has been frequently used to assist the characterization of natural ...
Naythan, Yeo, Shi Jun, Ang, Dillon, Tay
core   +1 more source