Results 51 to 60 of about 18,391,078 (250)

Unifying principles of bifunctional, proximity-inducing small molecules

Nature Chemical Biology, 2020
Nature uses a variety of tools to mediate the flow of information in cells, many of which control distances between key biomacromolecules. Researchers have thus generated compounds whose activities stem from interactions with two (or more) proteins ...
C. Gerry, S. Schreiber
semanticscholar   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Small Farm Quarterly - Summer 2004 [PDF]

, 2004
Small Farm Quarterly is for farmers and farm families — including spouses and children - who value the quality of life that smaller farms provide.CONTENTS: EDITORIAL: From the Editors by John Thurgood, Page 3; READERS WRITE: Page 3 & 5; SMALL FARM ...
Cornell Small Farms Program
core   +4 more sources

How We Think about Targeting RNA with Small Molecules

Journal of Medicinal Chemistry, 2020
RNA offers nearly unlimited potential as a target for small molecule chemical probes and lead medicines. Many RNAs fold into structures that can be selectively targeted with small molecules.
Matthew G. Costales, Jessica L. Childs‐Disney, Hafeez S Haniff, M. Disney   +3 more
semanticscholar   +1 more source

Excipients used in lyophilization of small molecules [PDF]

, 2010
This review deals with the excipients used in various lyophilized formulations of small molecules. The role of excipients such as bulking agents, buffering agents, tonicity modifiers, antimicrobial agents, surfactants and co-solvents has been discussed ...
Arvind Kumar Bansal, Kumar, Lokesh, Ankit Baheti, Baheti, Ankit, Lokesh Kumar, Bansal, Arvind Kumar   +5 more
core  

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

MolDiscovery: learning mass spectrometry fragmentation of small molecules

Nature Communications, 2020
Identification of small molecules is a critical task in various areas of life science. Recent advances in mass spectrometry have enabled the collection of tandem mass spectra of small molecules from hundreds of thousands of environments.
Liu Cao, Mustafa Guler, Azat M. Tagirdzhanov, Yi-Yuan Lee, A. Gurevich, H. Mohimani   +5 more
semanticscholar   +1 more source

A Modular Approach to Triazole-Containing Chemical Inducers of Dimerisation for Yeast Three-Hybrid Screening [PDF]

, 2013
The yeast three-hybrid (Y3H) approach shows considerable promise for the unbiased identification of novel small molecule-protein interactions. In recent years, it has been successfully used to link a number of bioactive molecules to novel protein binding
Nicholas J. Westwood, Gary Ward, Gary E. Ward, Odell, Anahi V., Anahi V. Odell, Fanny Tran, Tran, Fanny, Anahi Odell, Ward, Gary E., Westwood, Nicholas J., Nicholas Westwood   +10 more
core   +1 more source

An isoform of 14‐3‐3 protein regulates transbilayer lipid movement at the plasma membrane

FEBS Letters, EarlyView.
Loss of 14‐3‐3ζ in CHO cells confers resistance to exogenous phosphatidylserine (PS) and impairs endocytosis‐independent inward flip‐flop of fluorescent PS at the plasma membrane. RNAi‐mediated knockdown reproduces this defect, while no additive effect is seen in ATP11C‐deficient cells.
Akiko Yamaji‐Hasegawa, Akira Hattori, Masafumi Tsujimoto, Toshihide Kobayashi   +3 more
wiley   +1 more source