Results 91 to 100 of about 9,772,409 (292)
Discerning protein pools by selective staining with self‐labeling tags
FEBS Letters, EarlyView.Cell surface proteins have an intra‐ and extracellular pool. Combining genetic fusion to self‐labeling tags that can be addressed with small molecule fluorophores allows separating these pools. We highlight recent developments and techniques for state‐of‐the‐art interrogation of cell surface proteins in the complex tissue setting.
Kati Fischermanns, Johannes Broichhagen
wiley +1 more source
ELNet: An Efficient and Lightweight Network for Small Object Detection in UAV Imagery
Remote SensingReal-time object detection is critical for unmanned aerial vehicles (UAVs) performing various tasks. However, efficiently deploying detection models on UAV platforms with limited storage and computational resources remains a significant challenge.
Hui Li, Jianbo Ma, Jianlin Zhang
doaj +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Converting relational databases into object relational databases [PDF]
, 2010 This paper proposes an approach for migrating existing Relational DataBases (RDBs) into Object-Relational DataBases (ORDBs). The approach is superior to existing proposals as it can generate not only the target schema but also the data instances.
Ali, Akhtar +5 more
core +2 more sources
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Detection of small and camouflaged objects
Detecting small and camouflaged objects in aerial images is challenging, especially when data is acquired from drones. In such images, targets often occupy only a very small portion of the frame and can visually blend in with the surrounding terrain.
Krytskyi, Dmytro +2 more
openaire +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
A small‐target traffic sign detection algorithm based on partial conv and atrous spatial pyramid
IET Image ProcessingTraffic sign detection is essential to an intelligent driving assistance system. The deep learning‐based algorithm proposed in this paper aims to address the issue of low detection accuracy caused by the small size and high density of traffic signs in ...
Yuqi Li +5 more
doaj +1 more source
MCF-YOLOv5: A Small Target Detection Algorithm Based on Multi-Scale Feature Fusion Improved YOLOv5
InformationIn recent years, many deep learning-based object detection methods have performed well in various applications, especially in large-scale object detection.
Song Gao, Mingwang Gao, Zhihui Wei
doaj +1 more source