Results 121 to 130 of about 9,772,409 (292)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

PTCDet: advanced UAV imagery target detection

Scientific Reports
Object detection in drone aerial images is challenging due to the difficulty of small object detection and complex backgrounds. To address these issues, this paper proposes an improved object detection model, perception and target capture detector ...
Jia Su, Yichang Qin, Ze Jia, Yanli Hou
doaj   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A Small-Object-Detection Algorithm Based on LiDAR Point-Cloud Clustering for Autonomous Vehicles

Sensors
3D object-detection based on LiDAR point clouds can help driverless vehicles detect obstacles. However, the existing point-cloud-based object-detection methods are generally ineffective in detecting small objects such as pedestrians and cyclists ...
Zhibing Duan, Jinju Shao, Meng Zhang, Jinlei Zhang, Zhipeng Zhai   +4 more
doaj   +1 more source

Dataset for small object detection with shadow (SODwS)

Data in Brief
Detecting small objects in aerial images poses several challenges, including issues with resolution limitations, scale variability, background clutter, and object occlusion. Annotated datasets for small objects in aerial images are often scarce, complicating the training and validation of detection models.
Shahbe Mat-Desa, Wan-Noorshahida Mohd-Isa, Petra Gomez-Krämer, M. Roslee, Noramiza Hashim, Junaidi Abdullah, Aziah Ali, Zarina Che-Embi, Amalina Ibrahim   +8 more
openaire   +2 more sources

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Two‐Stage Approach to Small‐Object Detection

Systems Engineering
ABSTRACT Unmanned aerial systems (UAS) are increasingly finding applications in civilian and commercial sectors. The utilization of machine learning techniques in UAS image analysis significantly advances target detection and tracking algorithms.
Mingrui Yu, Henry Leung 0001
openaire   +2 more sources

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

DS-YOLOv7: Dense Small Object Detection Algorithm for UAV

IEEE Access
Modern unmanned aerial vehicle (UAV) reconnaissance is widely used. UAV equipped with FPV camera can realize the reconnaissance of dense small objects with the help of object detection technology.
Tao Sun, Haonan Chen, Haiying Liu, Lixia Deng, Lida Liu, Shuang Li   +5 more
doaj   +1 more source