Results 131 to 140 of about 549,904 (316)
Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer
Molecular Oncology, EarlyView.Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni +11 more
wiley +1 more source
Financial InnovationSmall-scale wind turbines are essential energy sources for hospitals because they have several advantages, such as lower maintenance costs and the possibility of customization.
Serhat Yüksel +4 more
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Value Engineering for Small Transportation Projects
, 2000 Although Value Engineering (VE) studies are mandated by the Federal Highway Administration for large ($25 million or more) federal-aid highway projects, many state Departments of Transportation do not conduct voluntary VE studies on smaller projects ...
Clark, Jennifer Anne
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E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Jurisdictional Disputes in the Simplification of Small-Scale Hydropower Regulation
, 1985 ISBN 0-913235-37-7In allowing exemptions from licensing for small hydro projects, Congress shifted most of the environmental review of these projects from the Federal Energy Regulatory Commission to state and federal fish and wildlife agencies.
Feil, J I
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KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Managing value, requirements and risk in the appraisal stage of UK construction projects [PDF]
, 2011 The construction industry in the United Kingdom has grown significantly and its ability to produce construction projects successfully has a significant impact on the whole economy’s performance.
Mlybari, Ehab Abduraheem.A. +1 more
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Molecular Oncology, EarlyView.EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain +10 more
wiley +1 more source
THE ROLE OF SMALL FIRMS IN CHINA’S TECHNOLOGY DEVELOPMENT [PDF]
Science & Technology (S&T) is high on the Chinese policy agenda but there are large uncertainties on the actual S&T development. For instance, previous studies tend to focus only on large and medium-sized enterprises (LMEs).
Lundin, Nannan +2 more
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