Engineering IL‐4 resistant proinflammatory human myeloid cells for cancer immunotherapy
Molecular Oncology, EarlyView.We developed a scalable workflow to generate proinflammatory human myeloid cells. CRISPR/Cas9‐edited CD34+ hematopoietic stem and progenitor cells were expanded and differentiated with M‐CSF. Deletion of STAT6 or STAT6/NFKB1 enhanced macrophage proinflammatory gene expression and cytokine secretion in the presence of IL‐4 while maintaining antibody ...
Theresa Barberi, Alan D. Friedman
wiley +1 more source
Small and medium enterprises, growth, and poverty : cross-country evidence [PDF]
The authors explore the relationship between the relative size of the small and medium enterprise (SME) sector, economic growth, and poverty using a new database on the share of SME labor in the total manufacturing labor force.
Thorsten Beck, Ross Levine
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Rank-based learning: a novel high-throughput algorithm resilient to missing data and effective for datasets with small sample size. [PDF]
Brief BioinformSong L +7 more
europepmc +1 more source
Spatial heterogeneity of hotspot mutations and clonal relatedness in ovarian endometrioid carcinoma
Molecular Oncology, EarlyView.Spatially resolved analysis revealed heterogeneous distributions of selected cancer‐associated mutations within ovarian endometrioid carcinomas. Shared mutations between paired endometrial and ovarian tumors supported clonal relatedness. These findings highlight the value of sampling multiple tumor regions when interpreting molecular profiles ...
Takahito Ashihara +10 more
wiley +1 more source
Sample size analysis for two-sample linear rank tests
, 2018 Sample size analysis is a key part of the planning phase of any research. So far, however, limited literature focusses on sample size analysis methods for two-sample linear rank tests, although these methods have optimal properties at different ...
Klein, Ingo, Doll, Monika
core
An Integrated Approach Using GA-XGBoost and GMM-RegGAN for Marine Corrosion Prediction Under Small Sample Size. [PDF]
Materials (Basel)Chen Q +5 more
europepmc +1 more source
Tumour‐proximal deep serum proteomics identifies biomarkers associated with ovarian cancer
Molecular Oncology, EarlyView.New biomarkers are needed for early ovarian cancer detection. Ovarian (tumour‐proximal) and peripheral vein serum from healthy women and patients with benign or malignant tumours underwent nanoparticle‐enriched deep proteomics. Ovarian serum yielded more protein identifications and revealed tumour‐reflective signatures.
Darren Lau +9 more
wiley +1 more source
The Effectiveness of Patient Education Interventions to Oncological Entero-Urostomy Patients and Caregivers: A Small Sample Size Pilot Study. [PDF]
DiseasesSpano A +10 more
europepmc +1 more source
Attitudes of cancer patients toward ctDNA‐based liquid biopsy for follow‐up
Molecular Oncology, EarlyView.This mixed‐methods study explored cancer patients' experiences, knowledge, and preferences regarding ctDNA‐based liquid biopsy for follow‐up. Awareness of ctDNA was low and recall of previous liquid biopsy was imperfect, yet acceptance was high.
Siddharth Chhajlani +7 more
wiley +1 more source
Family ownership, innovation and other context variables as determinants of sustainable entrepreneurship in SMEs: An empirical research study [PDF]
This study focuses on the prediction of sustainable entrepreneurship, that is, behavior which demonstrates a firm’s concern about the natural environment, especially among small and medium sized enterprises (SMEs). Using a random sample of 382 Dutch SMEs
Lorraine Uhlaner +3 more
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